Neural evidence of a role for spatial response selection in the learning of spatial sequences.


:Despite over 20 years of behavioral research, considerable disagreement remains regarding the locus of the cognitive mechanisms (e.g., stimulus encoding, response selection or response production) responsible for the acquisition and expression of learned sequences. Functional neuroimaging may prove invaluable for resolving this controversy. The cortical mechanisms underlying spatial response selection (i.e., right dorsal prefrontal, dorsal premotor and superior parietal cortices) are well known. These regions as well as supplementary motor area, striatum and the hippocampus have also been implicated in sequence learning. This neural overlap lends support for the hypothesis that spatial response selection is involved in learning spatial sequences; however, these experimental factors have not been investigated in the same experiment so the extent of neural overlap is debatable. The present study investigates the role of spatial response selection in sequence learning during the performance of the serial reaction time task. We orthogonally manipulated spatial sequence learning and spatial response-selection difficulty to precisely identify the neural overlap of these cognitive systems. Results demonstrate near complete overlap in regions affected by the spatial response selection and spatial sequence learning manipulations. Only right dorsal prefrontal cortex was selectively influenced by the response selection difficulty manipulation. These findings emphasize the importance of spatial response selection for successful spatial sequence learning.


Brain Res


Brain research


Schwarb H,Schumacher EH




Has Abstract


2009-01-09 00:00:00












  • Biotinylated m4-toxin demonstrates more M4 muscarinic receptor protein on direct than indirect striatal projection neurons.

    abstract::The striatum has nearly equal numbers of striatonigral and striatopallidal projection neurons. All are GABAergic and inhibitory, but they lie in separate neuronal circuits ('direct' and 'indirect', respectively) that appear to exert opposite effects on movement. Methods are needed to evaluate the function of each circ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Santiago MP,Potter LT

    更新日期:2001-03-09 00:00:00

  • Post-transcriptional regulation of loss of rat striatal D2 dopamine receptor during aging.

    abstract::The mechanism(s) underlying age-associated diminutions in the rat striatal D2 dopamine receptor (D2-receptor) number was investigated. The levels of D2-receptor mRNA in 4-, 12- and 18-month-old rat striata were found not to change. In contrast, the levels of 110 kDa protein, labeled with a D2-receptor specific antibod...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sakata M,Farooqui SM,Prasad C

    更新日期:1992-03-20 00:00:00

  • Effect of systemic zinc administration on delayed neuronal death in the gerbil hippocampus.

    abstract::The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Matsushita K,Kitagawa K,Matsuyama T,Ohtsuki T,Taguchi A,Mandai K,Mabuchi T,Yagita Y,Yanagihara T,Matsumoto M

    更新日期:1996-12-16 00:00:00

  • Age-related increase in oxidized proteins in mouse synaptic mitochondria.

    abstract::Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated their contents in synaptic mitochondria from five age groups of mice. Protein carbonyl content in synaptic mitochondria showed a significant positive correlation with age (r = 0.95, P = 0.01). A lin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Martinez M,Hernández AI,Martínez N,Ferrándiz ML

    更新日期:1996-08-26 00:00:00

  • Thyrotropin-releasing hormone (TRH) blocks glucagon-induced hyperglycemia in mice: dissociation of the antihyperglycemic and pituitary actions of TRH.

    abstract::Thyrotropin-releasing hormone (TRH) prevents the development of drug- or stress-induced hyperglycemia in mice through action at central sites. To study the role of the pituitary in mediating this action, we have evaluated the effect of TRH analogs lacking hypophysiotropic activity, acid-TRH and DN 1417, in blocking gl...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Amir S

    更新日期:1988-07-05 00:00:00

  • The network-selective actions of quinoxalines on the neurocircuitry operations of the rabbit retina.

    abstract::We examined the contribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxalole-4-propionic acid (AMPA)/kainate (KA) receptors to the light-responses of rabbit retinal neurons. In the outer retina, bath application of the AMPA/KA receptor antagonists 6,7-dinitro-quinoxaline-2,3-dione (DNQX) ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cohen ED,Miller RF

    更新日期:1999-06-12 00:00:00

  • Increased excitability and reduced intracortical inhibition in the ipsilateral primary motor cortex during a fine-motor manipulation task.

    abstract::The effects of a sensorimotor task on ipsilateral primary motor cortex (ipsi-M1) excitability mediated via the transcallosal pathway, including the changes in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), were examined in ten right-handed subjects. Transcranial magnetic stimulati...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morishita T,Ninomiya M,Uehara K,Funase K

    更新日期:2011-01-31 00:00:00

  • NMDA glutamate receptor stimulation is required for the expression of D2 dopamine mediated responses in apomorphine primed 6-hydroxydopamine lesioned rats.

    abstract::Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pollack AE,Haisley EC

    更新日期:2001-04-06 00:00:00

  • Evolution of Bergmann glia in developing human fetal cerebellum: a Golgi, electron microscopic and immunofluorescent study.

    abstract::Astrogliogenesis in the human fetal cerebellum was examined in 46 cerebella obtained from hysterotomy specimens ranging between 9 and 20 weeks of ovulation age. By correlating the results obtained by rapid Golgi and Golgi-Cox methods, the indirect immunofluorescence technique for glial fibrillary acidic protein, and e...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Choi BH,Lapham LW

    更新日期:1980-05-26 00:00:00

  • Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.

    abstract::Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, wh...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yu X,Imam SZ,Newport GD,Slikker W Jr,Ali SF

    更新日期:1999-03-27 00:00:00

  • Aluminum citrate uptake by immortalized brain endothelial cells: implications for its blood-brain barrier transport.

    abstract::The objective was to further test the hypothesis that aluminum (Al) citrate transport across the blood-brain barrier is mediated by a monocarboxylate transporter (MCT). Speciation calculations showed that Al citrates were the predominant Al species under the conditions employed. Al citrate did not inhibit lactate upta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yokel RA,Wilson M,Harris WR,Halestrap AP

    更新日期:2002-03-15 00:00:00

  • Brain tyrosine availability and the depression of central nervous norepinephrine turnover in acute and chronic starvation in adult male rats.

    abstract::Norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MOPEG) were determined in medio-basal hypothalamus of adult male rats using high-performance liquid chromatography to study nutritional modulation of noradrenergic turnover. Acute starvation, as well as 3 weeks of semistarvation with a low-protein high-carbohydr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schweiger U,Warnhoff M,Pirke KM

    更新日期:1985-06-03 00:00:00

  • Differential quenching and limits of resolution in autoradiograms of brain tissue labeled with 3H-, 125I- and 14C-compounds.

    abstract::Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lidow MS,Goldman-Rakic PS,Rakic P,Gallager DW

    更新日期:1988-08-30 00:00:00

  • Contribution of nucleus medianus to the drinking and pressor responses to angiotensin II acting at subfornical organ.

    abstract::The contribution of neurons in the nucleus medianus (NM) in mediating the drinking and pressor responses elicited by administration of angiotensin II (AII) either directly into the subfornical organ (SFO) or intravenously was investigated in conscious, unrestrained rats. Microinjection of AII into the SFO elicited a r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gutman MB,Jones DL,Ciriello J

    更新日期:1989-05-29 00:00:00

  • Vasopressin and glucoprivic-feeding behavior: a new perspective on an 'old' peptide.

    abstract::The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats hav...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Aravich PF,Sladek CD

    更新日期:1986-10-22 00:00:00

  • Postsynaptic potentials evoked in spiny neostriatal projection neurons by stimulation of ipsilateral and contralateral neocortex.

    abstract::Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wilson CJ

    更新日期:1986-03-05 00:00:00

  • Timing of 6-hydroxydopamine administration influences its effects on visual cortical plasticity.

    abstract::We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Allen EE,Blakemore LJ,Trombley PQ,Gordon B

    更新日期:1987-03-01 00:00:00

  • Basic fibroblast growth factor increases cortical blood flow in vivo.

    abstract::Basic FGF has recently been shown to produce systemic and cerebral vasodilation. To test the hypothesis that bFGF increases regional cortical blood flow (rCBF), rCBF and brain pHi were measured while bFGF or vehicle was superperfused onto the cortex of rabbits. The results of this study demonstrate that topical applic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Regli L,Anderson RE,Meyer FB

    更新日期:1994-11-28 00:00:00

  • Analysis of resurgent sodium-current expression in rat parahippocampal cortices and hippocampal formation.

    abstract::The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Castelli L,Nigro MJ,Magistretti J

    更新日期:2007-08-13 00:00:00

  • The collagenase model of intracerebral hemorrhage in awake, freely moving animals: The effects of isoflurane.

    abstract::Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wilkinson CM,Kalisvaart ACJ,Kung TFC,Maisey DR,Klahr AC,Dickson CT,Colbourne F

    更新日期:2020-02-01 00:00:00

  • Effects of feeding and insulin on extracellular acetylcholine in the amygdala of freely moving rats.

    abstract::Extracellular levels of acetylcholine (ACh) were measured in the central nucleus of the amygdala using microdialysis in 20-min intervals before, during, and after 1 h feeding in food-deprived rats. The results were compared to the effects of peripheral injections of glucose or 'low' (200 mU) and 'high' (1 U) doses of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hajnal A,Pothos EN,Lénárd L,Hoebel BG

    更新日期:1998-02-23 00:00:00

  • Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli.

    abstract::The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rasmussen K,Strecker RE,Jacobs BL

    更新日期:1986-03-26 00:00:00

  • Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions.

    abstract::Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Roman C,Lin JY,Reilly S

    更新日期:2009-03-09 00:00:00

  • Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat.

    abstract::Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vezina P

    更新日期:1993-03-12 00:00:00

  • Enhanced nitric oxide production during lead (Pb²⁺) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons.

    abstract::We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Neal AP,Stansfield KH,Guilarte TR

    更新日期:2012-02-23 00:00:00

  • Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist.

    abstract::Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dougherty PM,Willis WD

    更新日期:1991-02-22 00:00:00

  • Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease.

    abstract::Using previously characterized polyclonal antibody directed against dopamine beta-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from indivi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jengeleski CA,Powers RE,O'Connor DT,Price DL

    更新日期:1989-03-06 00:00:00

  • Photoperiodic dependent changes in the number of neurons containing mRNA encoding neuropeptide Y in the intergeniculate leaflet of the Syrian hamster.

    abstract::The intergeniculate leaflet (IGL) is a distinct division of the lateral geniculate complex that participates in the regulation of the circadian rhythm through its projections to the circadian pacemaker located in the suprachiasmatic nuclei of the hypothalamus. A high number of neuropeptide Y (NPY) cell bodies has been...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jacob N,Vuillez P,Moller M,Pévet P

    更新日期:1998-11-30 00:00:00

  • The coexistence of two neuroactive peptides in a subpopulation of retinal amacrine cells.

    abstract::Amacrine cells are axonless interneurons of the vertebrate retina. Over the past few years many neuroactive peptides have been localized to these cells. We have previously demonstrated that a neuropeptide and a classical transmitter are colocalized in some amacrine cells. In this report, we show that two neuroactive p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Li HB,Watt CB,Lam DM

    更新日期:1985-10-14 00:00:00

  • Tumor necrosis factor-alpha inhibits physiologically identified dorsal motor nucleus neurons in vivo.

    abstract::Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Emch GS,Hermann GE,Rogers RC

    更新日期:2002-10-04 00:00:00