Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury.

Abstract:

:At various times after spinal nerve injury, dorsal root ganglia (DRGs) from injured segments were removed with attached dorsal roots and spinal nerves. In an in vitro recording chamber, spontaneously active units were recorded from teased dorsal root fascicles. Sustained spontaneous activity could first be recorded at 13 h after the ligation, but adrenergic sensitivity did not develop until 24 h after the injury. Almost all recorded activity originated from the DRG. Thus, the DRG is the most common site for ectopic discharge generation after spinal nerve injury and separate mechanisms seem to be involved in the development of ectopic discharges and adrenergic sensitivity.

journal_name

Brain Res

journal_title

Brain research

authors

Liu X,Chung K,Chung JM

doi

10.1016/s0006-8993(99)02165-4

subject

Has Abstract

pub_date

1999-12-04 00:00:00

pages

244-7

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)02165-4

journal_volume

849

pub_type

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