Abstract:
:Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine followed by methamphetamine injection showed no hyperthermia and decreased HSP-72 expression. These data indicate that pretreatment with ibogaine can completely block methamphetamine-induced hyperthermia and HSP-72 expression in the striatum.
journal_name
Brain Resjournal_title
Brain researchauthors
Yu X,Imam SZ,Newport GD,Slikker W Jr,Ali SFdoi
10.1016/s0006-8993(99)01154-3subject
Has Abstractpub_date
1999-03-27 00:00:00pages
213-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01154-3journal_volume
823pub_type
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