Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.

Abstract:

:Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine followed by methamphetamine injection showed no hyperthermia and decreased HSP-72 expression. These data indicate that pretreatment with ibogaine can completely block methamphetamine-induced hyperthermia and HSP-72 expression in the striatum.

journal_name

Brain Res

journal_title

Brain research

authors

Yu X,Imam SZ,Newport GD,Slikker W Jr,Ali SF

doi

10.1016/s0006-8993(99)01154-3

subject

Has Abstract

pub_date

1999-03-27 00:00:00

pages

213-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01154-3

journal_volume

823

pub_type

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