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Effect of hyperglycemia on extracellular levels of amino acids and free fatty acids in the ischemic/reperfused rat cerebral cortex.

Abstract：

:This study analyzed the effects of pre-existing hyperglycemia on the extracellular levels of glutamate, other amino acids and free fatty acids, including arachidonic acid, in the ischemic/reperfused rat cerebral cortex, using a cortical cup technique. Forebrain cerebral ischemia (20 min) was induced by four vessel occlusion. Glucose (3.4 g/kg) was administered 30 min prior to ischemia. Glucose administration had no effect on basal levels of superfusate amino acids and reduced basal levels of linoleic and oleic acids. Cerebral ischemia elicited increased superfusate levels of aspartate, glutamate, phosphoethanolamine, taurine, gamma-aminobutyric acid (GABA) and arachidonic acid when compared with basal levels. Reperfusion caused a further increase in phosphoethanolamine and arachidonic acid levels and transient increases in linoleic, oleic and palmitic acids. Hyperglycemia resulted in significantly reduced levels of glutamate, phosphoethanolamine, GABA and arachidonic, myristic, palmitic, linoleic and oleic acids during ischemia/reperfusion in comparison with the saline-injected ischemic controls. The results indicate that ischemia/reperfusion-evoked increases in the extracellular levels of glutamate, certain other amino acids and free fatty acids are attenuated by prior systemic glucose administration.

journal_name

Brain Res

journal_title

Brain research

authors

Phillis JW,Song D,O'Regan MH

doi

10.1016/s0006-8993(99)01700-x

subject

Has Abstract

pub_date

1999-08-07 00:00:00

pages

177-83

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01700-X

journal_volume

837

pub_type

杂志文章

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