Noradrenergic lesion of the locus coeruleus increases the firing activity of the medial prefrontal cortex pyramidal neurons and the role of alpha2-adrenoceptors in normal and medial forebrain bundle lesioned rats.

abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...

journal_title：Brain research

authors： Han Q,Liu S,Li Z,Hu F,Zhang Q,Zhou M,Chen J,Lei T,Zhang H

更新日期：2014-01-13 00:00:00

abstract：:How does attention interact with learning? Kruschke [Kruschke, J.K. (2001). Toward a unified Model of Attention in Associative Learning. J. Math. Psychol. 45, 812-863.] proposed a model (EXIT) that captures Mackintosh's [Mackintosh, N.J. (1975). A theory of attention: Variations in the associability of stimuli with re...

journal_title：Brain research

authors： Pauli WM,O'Reilly RC

更新日期：2008-04-02 00:00:00

abstract：:Protein uptake and transport within the brain stem vasculature of mechanically brain injured cats was studied by means of both light and electron microscopy utilizing intravenously injected horseradish peroxidase as the protein tracer. In animals sustaining low grade head injuries not of sufficient intensity to elicit...

journal_title：Brain research

authors： Povlishock JT,Becker DP,Sullivan HG,Miller JD

更新日期：1978-09-22 00:00:00

abstract：:Correlative light and electron microscopic methods were used to examine the morphology, distribution and synaptic connections of double bouquet cells immunoreactive for the calcium-binding protein calbindin D-28k in the human temporal neocortex. Double bouquet cells form symmetric synapses with small dendritic shafts ...

journal_title：Brain research

authors： del Río MR,DeFelipe J

更新日期：1995-08-28 00:00:00

abstract：:An in vitro method has been developed to determine quantitatively the permeability of the perineurium to radiotracers at room temperature. The permeability to [14C]sucrose of the isolated perineurium of the sciatic nerve of the frog, Rana pipiens, was measured at rest length, when the perineurium was stretched and aft...

journal_title：Brain research

authors： Weerasuriya A,Rapoport SI,Taylor RE

更新日期：1979-09-21 00:00:00

abstract：:In recent years microvillar cells (MVC) have been identified in the olfactory epithelium of numerous species, including rodents, canines, and primates. However, there is no consensus on the morphologic or histochemical features of this cell, nor is the function of these cells currently known. Previous studies have exa...

journal_title：Brain research

authors： Miller ML,Andringa A,Evans JE,Hastings L

更新日期：1995-01-09 00:00:00

abstract：:Previous studies in our laboratory using rat brain tissue have shown that neuropeptide Y (NPY) can enhance NMDA- and potassium-stimulated dopamine release from various brain regions and that this enhancement is reversed by sigma (sigma) receptor antagonists. In the current study, we sought to determine whether SH-SY5Y...

journal_title：Brain research

authors： Ault DT,Werling LL

更新日期：2000-09-22 00:00:00

abstract：:Mice which carry both the shiverer (shi) and the jimpy (jp) mutations have a morphological phenotype with features of each single mutation by itself but in milder form: the number of myelin sheaths is increased relative to jp, the thickness of sheaths and amount of major dense line is increased relative to shi, and th...

journal_title：Brain research

authors： Billings-Gagliardi S,Wolf MK,Kirschner DA,Kerner AL

更新日期：1986-05-21 00:00:00

abstract：:The malformative cortical lesions in the cerebral cortex that are characteristic of focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Increasing evidence suggests that extracellular matrix molecules play important rol...

journal_title：Brain research

authors： Li S,Yu S,Zhang C,Shu H,Liu S,An N,Yang M,Yin Q,Yang H

更新日期：2012-05-09 00:00:00

abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

journal_title：Brain research

authors： Fukuda H,Fukai K

更新日期：1986-08-20 00:00:00

abstract：:In this study, we examined the immunohistochemical occurrence and distribution of glial cell line-derived neurotrophic factor (GDNF) in autoptic specimens of normal human hippocampus at different ages, from 22 weeks of gestation (w.g.) to adult life. Two different anti-GDNF polyclonal antibodies were used. Western blo...

journal_title：Brain research

authors： Pina Serra M,Quartu M,Ambu R,Follesa P,Del Fiacco M

更新日期：2002-02-22 00:00:00

abstract：:While schizophrenia has a genetic component, its pathogenesis is unknown. Abnormal concentrations of two cell recognition molecules (CRMs), neural-cell adhesion molecule (N-CAM) and L1 antigen have been described in the cerebrospinal fluid (CSF) of patients with schizophrenia. Studies of monozygotic twins discordant f...

journal_title：Brain research

authors： Poltorak M,Wright R,Hemperly JJ,Torrey EF,Issa F,Wyatt RJ,Freed WJ

更新日期：1997-03-14 00:00:00

abstract：:The rate and pattern of seizure development provoked by repeated electrical stimulation of the amygdala (kindling) was assessed in rats that had been pretreated with intracerebral injections of the selective catecholaminergic neurotoxin 6-hydroxy-dopamine. Rats with selective depletion of forebrain noradrenaline displ...

journal_title：Brain research

authors： Corcoran ME,Mason ST

更新日期：1980-05-26 00:00:00

abstract：:Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potent...

journal_title：Brain research

authors： Kumar A,Foster TC

更新日期：2005-01-07 00:00:00

abstract：:The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...

journal_title：Brain research

authors： Pudovkina OL,Kawahara Y,de Vries J,Westerink BH

更新日期：2001-07-06 00:00:00

abstract：:Although it has been reported that dendritic neurotransmitter releases from amacrine cells are regulated by the intracellular Ca(2+) concentration ([Ca(2+)](i)), their spatiotemporal patterns are not well explained. Fast Ca(2+) imagings of amacrine cells in the horizontal slice preparation of goldfish retinas under wh...

journal_title：Brain research

authors： Azuma T,Enoki R,Iwamuro K,Kaneko A,Koizumi A

更新日期：2004-10-08 00:00:00

abstract：:The amplitude of anterior neocortical EEG slow-waves (0.5-4 Hz) measured during quiet waking, drowsy (WS) and synchronized sleep (S) states showed slow rhythmic oscillations in WS and S similar to those previously reported in midbrain reticular neurons (periods of 8-12 s). Abrupt changes in slow rhythms of unit discha...

journal_title：Brain research

authors： Oakson G,Steriade M

更新日期：1983-06-20 00:00:00

abstract：:The mismatch negativity is an electrophysiological marker of auditory change detection in the event-related brain potential and has been proposed to reflect an automatic comparison process between an incoming stimulus and the representation of prior items in a sequence. There is evidence for two main functional subcom...

journal_title：Brain research

authors： Fuentemilla L,Marco-Pallarés J,Münte TF,Grau C

更新日期：2008-07-18 00:00:00

abstract：:A method to study the protein binding patterns of trace elements in human cerebrospinal fluid (CSF) is described. Proteins in CSF samples were separated by size exclusion chromatography combined with high performance liquid chromatography (SEC-HPLC). The column was calibrated to separate proteins in the molecular weig...

journal_title：Brain research

authors： Gellein K,Roos PM,Evje L,Vesterberg O,Flaten TP,Nordberg M,Syversen T

更新日期：2007-10-12 00:00:00

abstract：:We examined the role of the phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) and cyclic AMP-response element binding protein (CREB) in N-methyl-d-aspartate (NMDA)-induced neurotoxicity in the rat retina. Western blot analysis showed early elevation of phosphorylated CaMKII (p-CaMKII) protein ...

journal_title：Brain research

authors： Takeda H,Kitaoka Y,Hayashi Y,Kumai T,Munemasa Y,Fujino H,Kobayashi S,Ueno S

更新日期：2007-12-12 00:00:00

abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...

journal_title：Brain research

authors： Cooper B,Werner HB,Flügge G

更新日期：2008-03-04 00:00:00

abstract：:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...

journal_title：Brain research

authors： Savage DD,Nadler JV,McNamara JO

更新日期：1984-12-03 00:00:00

abstract：:In this study we examined blood pressure and heart rate responses to intrathecal administration of a synthetic NK1-receptor agonist, H2N-(CH2)4-CO-Phe-Phe-Pro-NmeLeu-Met-NH2 (GR 73,632), in spontaneously hypertensive rats (SHR) and their progenitor strain, the Wistar-Kyoto rat (WKY). Sodium pentobarbitone anaesthetise...

journal_title：Brain research

authors： Solomon SG,Llewellyn-Smith IJ,Minson JB,Arnolda LF,Chalmers JP,Pilowsky PM

更新日期：1999-01-02 00:00:00

abstract：:Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...

journal_title：Brain research

authors： Kuo MC,Dringenberg HC

更新日期：2012-12-07 00:00:00

abstract：:Intracellular recordings were obtained from facial motoneurons in anesthetized rats. The effects of iontophoretically applied serotonin were compared to those of the excitatory amino acids glutamate and DL-homocysteic acid (DLH), and the inhibitory amino acids, glycine, GABA and muscimol, under various conditions of m...

journal_title：Brain research

authors： Vandermaelen CP,Aghajanian GK

更新日期：1982-05-06 00:00:00

abstract：:The roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitization of chronic visceral pain were investigated. A rat model with irritable bowel syndrome (IBS) was established by colorectal distention (CRD) on post-natal days 8-14. Responses of the external oblique muscle of the abdomen to...

journal_title：Brain research

authors： Luo XQ,Cai QY,Chen Y,Guo LX,Chen AQ,Wu ZQ,Lin C

更新日期：2014-01-13 00:00:00

abstract：:Experiments were conducted to (1) provide further evidence of the selectivity of [D-Ala2,Leu5,Cys6]enkephalin (DALCE) as an antagonist of delta (delta) receptor ligands and (2) use DALCE as a tool to explore the possible role of delta receptors in restraint stress. Dose- and time-response curves were generated for the...

journal_title：Brain research

authors： Calcagnetti DJ,Bowen WD,Holtzman SG

更新日期：1990-02-19 00:00:00

abstract：:To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...

journal_title：Brain research

authors： Owashi T,Iritani S,Niizato K,Ikeda K,Kamijima K

更新日期：2004-06-04 00:00:00

abstract：:The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were s...

journal_title：Brain research

authors： Miwa H,Nishi K,Fuwa T,Mizuno Y

更新日期：1998-01-19 00:00:00

abstract：:Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male a...

journal_title：Brain research

authors： Vela G,Fuentes JA,Bonnin A,Fernández-Ruiz J,Ruiz-Gayo M

更新日期：1995-05-22 00:00:00