Abstract：
:While schizophrenia has a genetic component, its pathogenesis is unknown. Abnormal concentrations of two cell recognition molecules (CRMs), neural-cell adhesion molecule (N-CAM) and L1 antigen have been described in the cerebrospinal fluid (CSF) of patients with schizophrenia. Studies of monozygotic twins discordant for schizophrenia may help separate genetic and environmental contributions to the disease. In the present study of monozygotic twins discordant for schizophrenia, the affected twins had increased N-CAM and decreased L1 antigen in their CSF. Non-affected twins were not different from normals. Although processes related to genetic instability cannot be entirely ruled out, these results suggest that these abnormalities are not a part of the genetic predisposition to become schizophrenic. Thus the changes in N-CAM and L1 antigen may reflect either the events which precipitated the onset of schizophrenia, or events which are associated with the experience of having the disease.
journal_name
Brain Resjournal_title
Brain researchauthors
Poltorak M,Wright R,Hemperly JJ,Torrey EF,Issa F,Wyatt RJ,Freed WJdoi
10.1016/s0006-8993(97)00023-1subject
Has Abstractpub_date
1997-03-14 00:00:00pages
152-4issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00023-1journal_volume
751pub_type
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