Abstract：
:The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium omission in the LC decreased noradrenaline levels in the LC, but increased its levels in the PFC. Novelty increased noradrenaline levels in both structures. Infusion of the alpha(2)-adrenoceptor agonist clonidine decreased extracellular noradrenaline in the LC as well as in the PFC. Infusion of the alpha(2A)-adrenoceptor antagonist BRL44408, or the alpha(1)-adrenoceptor agonist cirazoline into the LC or PFC caused a similar dose-dependent increase in both structures. When BRL44408 or cirazoline were infused into the LC, few effects were seen in the PFC. Infusion of the 5-HT(1A)-receptor agonist flesinoxan into the LC or the PFC decreased the release of noradrenaline in both structures. When flesinoxan was infused into the LC, no effects were seen in the PFC. When the GABA(A) antagonist bicuculline was applied to the LC, noradrenaline increased in the LC as well as in the PFC. It is concluded that the release of noradrenaline from somatodendritic sites and nerve terminals responded in a similar manner to presynaptic receptor modulation. The possible existence of dendritic noradrenaline release is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Pudovkina OL,Kawahara Y,de Vries J,Westerink BHdoi
10.1016/s0006-8993(01)02553-7subject
Has Abstractpub_date
2001-07-06 00:00:00pages
38-45issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02553-7journal_volume
906pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Reports suggested that the predominant site of action for the antihypertensive effects of clonidine is the rostral ventrolateral medulla (RVL), the presumed tonic vasomotor center. This study examined whether clonidine directly interacts with nerve terminal alpha 2-adrenergic receptors in the RVL to inhibit the releas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90355-f
更新日期：1990-12-24 00:00:00
abstract：:Artificial CSF containing 12mEq/1 of potassium (4 times normal concentration) was perfused over the surface of normal neocortex in 10 locally or barbiturate anesthetized cats. Extracellular potassium concentrations ([K+]OS) were measured as a function of time to 8 h and of depth to 3 mm. Analysis of the [K+]O versus d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90265-1
更新日期：1976-01-16 00:00:00
abstract：:A lesion of the septum or a transection of the fimbria-fornix diminishes most, but not all, acetylcholinesterase (AChE) staining in the hippocampal formation. The residual AChE is located in the outer part of the molecular layer of the hippocampal CA1 zone and adjacent subicular field (zone 31). We report that followi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90583-8
更新日期：1983-08-08 00:00:00
abstract：:This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal day 5 to 21 were sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02248-4
更新日期：2000-06-09 00:00:00
abstract：:Intraventricular injections of kainic acid were used to destroy the hippocampal CA3-CA4 cells, thus denervating the inner third of the molecular layer of the fascia dentata and stratum radiatum and stratum oriens of area CA1. The responses of intact afferents to such lesions were then examined histologically. The hipp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90825-2
更新日期：1980-01-20 00:00:00
abstract：:There is an abundance of evidence suggesting that the area postrema (AP) is involved in the central actions of arginine-vasopressin (AVP) and angiotensin II (Ang II) on cardiovascular regulation. Furthermore, recent studies have shown that activation of the AP facilitates the response of nucleus tractus solitarius (NT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91323-4
更新日期：1994-06-06 00:00:00
abstract：:Movement of fragmented DNA in dendrites of retinal neurons during the apoptotic cell death was investigated. The time-course of the movement of fragmented DNA in dendrites of retinal neurons undergoing apoptotic cell death induced by intravitreal N-methyl-d-aspartate (NMDA) injection were examined by in situ terminal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.075
更新日期：2004-05-08 00:00:00
abstract：:Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.011
更新日期：2016-06-15 00:00:00
abstract：:Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.10.019
更新日期：2015-12-10 00:00:00
abstract：:The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90142-6
更新日期：1976-05-14 00:00:00
abstract：:Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.092
更新日期：2011-04-28 00:00:00
abstract：:This paper describes an electrochemical method for the detection of dopamine and serotonin in vitro. Dopamine and serotonin can be distinguished from each other without interference from metabolites. 3-4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid. The method also provides selective differentiation of do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91224-9
更新日期：1989-08-21 00:00:00
abstract：:Amacrine cells are axonless interneurons of the vertebrate retina. Over the past few years many neuroactive peptides have been localized to these cells. We have previously demonstrated that a neuropeptide and a classical transmitter are colocalized in some amacrine cells. In this report, we show that two neuroactive p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90850-9
更新日期：1985-10-14 00:00:00
abstract：:Five pairs of neurosecretory cells in the subesophageal ganglion of the silkmoth Bombyx mori discharge action potentials in (near) synchrony to release a pheromone biosynthesis-activating neuropeptide (PBAN). Waveforms of compound action potentials recorded extracellularly from axonal tracts were analyzed to determine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03349-2
更新日期：2002-03-08 00:00:00
abstract：:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90615-9
更新日期：1987-09-01 00:00:00
abstract：:The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.023
更新日期：2006-03-10 00:00:00
abstract：:α-Synuclein (α-syn) and oxidative stress play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, the mechanisms underlying the interaction between α-syn and oxidative stress remain poorly understood. The present study provides evidence to suggest that the nuclear translocation of α-syn increases d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.01.024
更新日期：2013-03-15 00:00:00
abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:Secondary hemorrhage after thrombolysis in ischemic stroke is an important complication, which has been difficult to study in preclinical disease models. We have established and characterized a model of thromboembolic middle cerebral artery occlusion in rats. Advantages of this model include a very low rate of spontan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.067
更新日期：2011-01-12 00:00:00
abstract：:Separate series of adult rats were subjected to unilateral high cervical and low thoracic section of the rubrospinal tract and sacrificed 1-30 (cervical series) and 3-100 days (thoracic series) later. Local cerebral glucose utilization ([14C]2-DG method of Sokoloff et al.) was determined in the red nucleus and in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90035-0
更新日期：1984-12-24 00:00:00
abstract：:Damage to the cerebral endothelium from ischemia could exacerbate brain injury by altering vascular integrity, but little is known concerning the response of cerebral endothelial cells to hypoxia. To address this issue, cerebral capillary endothelial cells were isolated from 14-day-old rats, grown to confluence, and p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90367-0
更新日期：1994-08-08 00:00:00
abstract：:Noxious heat applied to the footpad evokes the expression of fos protein-like immunoreactivity in the rat spinal cord lumbar dorsal horn. Electrical stimulation in the medullary nucleus raphe magnus (NRM) while not evoking fos-like immunoreactivity itself, reduced significantly the number of neurons (to 50% of control...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91306-2
更新日期：1990-10-22 00:00:00
abstract：:The climbing fiber input to the cerebellar cortex was destroyed using both electrolytic and chemical (3-acetylpyridine) lesions. The long-term effects of climbing fiber deafferentation on the ansiform lobule of weanling and adult rats were examined at both the light and electron microscopic levels. Image analysis of G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90022-3
更新日期：1986-09-24 00:00:00
abstract：:Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90121-o
更新日期：1992-02-21 00:00:00
abstract：:We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.034
更新日期：2006-08-09 00:00:00
abstract：:Increasing evidences show that hippocampal synaptic plasticity plays a crucial role in the pathogenesis of depression. The objective of this study was to determine whether electroacupuncture (EA) in the Wistar Kyoto (WKY) rat model of depression would exert antidepressant effects and whether this effect would be assoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.10.033
更新日期：2015-12-10 00:00:00
abstract：:It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01101-3
更新日期：1998-01-01 00:00:00
abstract：:In animals with retinal degeneration, the presence of activated microglial cells in the outer retina during the early stages of injury suggests that they may be involved in the ensuing photoreceptor cell death. In the following study, we investigated the effects of rat retina-derived microglial cells on a photorecepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01625-x
更新日期：1999-07-31 00:00:00
abstract：:Leukocyte behavior in the cerebral microvasculature following vessel occlusion has not been fully elucidated. The purpose of this study was to investigate the effects of cilostazol on leukocyte behavior (rolling and adhesion) in murine cerebral microvessels following transient bilateral carotid artery occlusion using ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.11.017
更新日期：2014-01-16 00:00:00
abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90964-9
更新日期：1986-06-04 00:00:00
