Abstract：
:Neuronal cells in primary culture have been demonstrated to possess specific insulin receptors (Boyd et al., J. Biol. Chem., 260 (1985) 15880-15884). Incubation of these cultures with insulin causes a dose-dependent inhibition of maprotiline-sensitive [3H]norepinephrine uptake. Maximum inhibition of 95% of maprotiline-sensitive norepinephrine uptake was observed at an insulin concentration of 167 nM with an ED50 of 30 nM. Competition-inhibition and Scatchard analysis of the insulin binding data suggested that maprotiline competed for high-affinity insulin receptors. These observations suggest that both insulin and maprotiline specifically inhibit neuronal norepinephrine uptake possibly involving insulin receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Boyd FT Jr,Clarke DW,Raizada MKdoi
10.1016/0006-8993(86)91242-4subject
Has Abstractpub_date
1986-11-19 00:00:00pages
1-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91242-4journal_volume
398pub_type
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