Abstract:
:The bed nucleus of the stria terminalis (BNST) receives dense noradrenergic projections from the brainstem and has been claimed to play a role in expression of a variety of stress responses. Fear-related stimuli suppress vasopressin and facilitate oxytocin release from the neurohypophysis and induce behavioral suppression. Here we investigated in male rats whether conditioned fear stimuli increase noradrenergic activity in the BNST and whether depletion of epinephrine content in the BNST prevents neuroendocrine and behavioral responses to fear stimuli. Environmental stimuli previously paired with electric footshocks increased the ratio of 3-methoxy-4-hydroxyphenylglycol to norepinephrine contents in the BNST, suggesting that the stimuli activated noradrenergic projections to the BNST. 5-Amino-2, 4-dihydroxy-alpha-methylphenylethylamine, a neurotoxin relatively selective for noradrenergic fibers, when injected into the BNST 7 days before measurement, decreased the content of norepinephrine by 95% and that of dopamine or serotonin by about 50%. In the rats that received the neurotoxin, the suppressive vasopressin but not the augmentative oxytocin response to intermittent footshocks was abolished. In the experiments with conditioned fear stimuli, the neurotoxin given before training partially but significantly impaired the suppressive vasopressin and behavioral responses to testing stimuli. The neurotoxin given after training, however, did not prevent the vasopressin, oxytocin or behavioral responses. The results suggest that noradrenergic fibers in the BNST mediate the suppressive vasopressin but not the augmentative oxytocin response to nonassociatively applied fear stimuli and that they modulate, in a facilitative fashion, acquisition but not retention or recall of the emotional memory associated with the vasopressin and behavioral responses to conditioned fear stimuli.
journal_name
Brain Resjournal_title
Brain researchauthors
Onaka T,Yagi Kdoi
10.1016/s0006-8993(98)00012-2subject
Has Abstractpub_date
1998-03-30 00:00:00pages
287-93issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00012-2journal_volume
788pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We have previously shown that hypothyroidism produces a decrease in the number of spines counted along the apical shafts of pyramidal neurons of the cortex. Nevertheless, other authors have found that when an animal is subjected to some adverse living conditions the size of the spines decreases, making them invisible ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90057-5
更新日期:1985-07-01 00:00:00
abstract::Fifteen adult male Sprague-Dawley rats were implanted with a set of electrodes for standard sleep recordings. A stainless steel cannula was also implanted into the lateral ventricle of these rats. Fifteen additional rats were implanted with a cannula alone. Rats with electrodes were habituated for 3 days or more to th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90888-5
更新日期:1994-10-03 00:00:00
abstract::The fine structure of reaggregating cultures of cells from 6- to 7-day-old mouse cerebellum was studied at intervals between 3 and 21 days in vitro (DIV). The resulting aggregates consisted mainly of small neurons (granule, stellate and basket cells), neuroglial cells and their processes. Large neurons were rarely pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90067-1
更新日期:1984-09-01 00:00:00
abstract::Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00053-5
更新日期:1998-04-20 00:00:00
abstract::Pregabalin is useful for treating neuropathic pain, but known to increase body weight as a side effect. To investigate the mechanism of this increase in body weight, we focused on dopamine in the lateral hypothalamus (LH) and examined the effects of pregabalin on dopamine levels in the LH and food intake. The dopamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.09.026
更新日期:2018-12-15 00:00:00
abstract::The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00997-3
更新日期:1996-11-04 00:00:00
abstract::The response of trunk neural crest cells taken from precise levels of the neural axis and cultured together with adjacent somites to Brain-derived neurotrophic factor (BDNF), was examined in cultures grown in a chemically defined medium. In control cultures, the number of neural crest-derived neurons expressing the HN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90171-x
更新日期:1988-06-01 00:00:00
abstract::The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the GABA receptors within the CeA are involved in this m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.068
更新日期:2004-11-26 00:00:00
abstract::Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03191-7
更新日期:2001-02-09 00:00:00
abstract::Suppression of geniculate ponto-geniculo-occipital (PGO) waves was achieved in kittens by performing bilateral mesencephalic lesions of the PGO pathways. Sleep-wake parameters and the spontaneous unit activity in the lateral geniculate nucleus (LGN) were then chronically recorded during one month after the lesions. Wh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90735-9
更新日期:1987-04-14 00:00:00
abstract::The luteinizing hormone-releasing hormone (LHRH) system of the platyfish Xiphophorus has been studied using immunohistochemistry and retrograde transport of horseradish peroxidase (HRP). Three different populations of LHRH-positive cell bodies are present in the brain, one in the ventral telencephalon at the border to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91059-3
更新日期:1981-09-21 00:00:00
abstract::The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01112-2
更新日期:1996-12-16 00:00:00
abstract::We have studied magnetic and electrical fields of the brain in normal subjects during the performance of an auditory verbal short-term memory task. On each trial 3 digits, selected from the numbers 'one' through 'nine', were presented for memorization followed by a probe number which could or could not be a member of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90767-p
更新日期:1991-09-06 00:00:00
abstract::We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.038
更新日期:2005-09-28 00:00:00
abstract::The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.09.021
更新日期:2018-12-15 00:00:00
abstract::The respiratory function of cerebral mitochondria harvested from genetically diabetic (BB/W) and streptozotocin-diabetic rats deprived of insulin for 3-4 weeks was found to be unchanged from control values. Furthermore, insulin-deprived BB/W rats subjected to 30 min of insulin-induced hypoglycemic coma demonstrated a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91624-7
更新日期:1989-02-13 00:00:00
abstract::The syndrome of vacuous chewing movements (VCMs) in rats is similar in many respects to tardive dyskinesia (TD) in humans. Both syndromes are characterized by delayed onset of persistent orofacial dyskinesias in a sub-group of subjects chronically treated with neuroleptics. Using the rat model, we examined the role of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00196-6
更新日期:1998-06-15 00:00:00
abstract::Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep. In the absence of stressors, CRH contributes to the regulation of spontaneous waking. We examined the effects of CRH and astressin (AST), a non-speci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.007
更新日期:2008-01-23 00:00:00
abstract::The development of afferent projections to the cerebellum was studied by making small (20 nl) injections of True blue into the cerebella of neonatal rats under general anaesthesia. Neurones in all main precerebellar nuclei were labelled even in rats less than one day old. With the exception of the disappearance of sma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90037-5
更新日期:1988-04-01 00:00:00
abstract::Prenatal exposure to chlorpyrifos (CPF) leads to cognitive impairments in adulthood. The cytoarchitectural basis is unclear. In the present study, we assessed the effects of prenatal CPF exposure on T-maze delayed alternation task and the win-shift/lose-shift responses associated with the morphology of the dorsal hipp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.07.036
更新日期:2012-09-20 00:00:00
abstract::The time course of the neurogenesis of cells showing glutamic acid decarboxylase (GAD) immunoreactivity has been analyzed in the dorsal hippocampus and area dentata of the mouse. The quantitative data indicate that gamma-aminobutyric acid (GABA)ergic cells are generated prenatally, and that their peaks of neurogenesis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80012-9
更新日期:1986-11-01 00:00:00
abstract::In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic prope...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.11.001
更新日期:2014-01-16 00:00:00
abstract::We measured the effect of high PCO (500-550 Torr) on the pHi and [Ca2+]i in cultured glomus cells of adult rat carotid body (CB) as a test of the two models currently proposed for the mechanism of CB chemoreception. The metabolic model postulates that the rise in glomus cell [Ca2+]i, the initiating reaction in the sig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00607-6
更新日期:1998-08-24 00:00:00
abstract::Cytosolic enzymes AMP deaminase and adenosine deaminase (ADA) catalyze AMP and adenosine deamination, constitute rate-limiting steps of adenine nucleotide catabolism and play important roles in cellular energy metabolism. In this study, AMP deaminase and ADA activities of rat liver, neocortex, cerebellum, striatum and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.073
更新日期:2010-01-22 00:00:00
abstract::The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an orig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90788-o
更新日期:1993-04-09 00:00:00
abstract::Astrocytes associated with beta-amyloid (Aβ)-deposited senile plaques are a common neuropathological feature of Alzheimer's disease (AD). There is little doubt that the association of Aβ with the major component in the central nervous system cells significantly influences disease progression, however, the molecular me...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.12.062
更新日期:2012-03-02 00:00:00
abstract::By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90957-7
更新日期:1987-08-18 00:00:00
abstract::In the search for cortical mechanisms subserving psychological phenomena, a better understanding of human cortical circuitry is crucial. In this report we describe aspects of intrinsic connectivity of supragranular layers in human visual cortex, revealed by extracellular injections of the anterograde tracer biocytin i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91148-8
更新日期:1992-10-30 00:00:00
abstract::We report here the in vivo effects of estrogen (E2) on modulation of synaptic plasticity and the agonistic (estrogen-like) role of selective estrogen receptor modulator (SERM), tamoxifen (TAM) in the CA1 of the rat hippocampus. Effects on synaptophysin (SYP), a presynaptic vesicular protein, and phosphorylated cyclic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.027
更新日期:2007-02-09 00:00:00
abstract::The potential evoked at the surface of the cerebral cortex of a guinea pig, by stimulation of the contralateral forepaw, usually consists of an initial double positive wave whose waveform remains unchanged during rapid stimulation. In a guinea pig with experimental allergic encephalomyelitis (EAE) the response is atte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90350-9
更新日期:1975-08-08 00:00:00