Abstract：
:Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate whether HRW could moderate parvalbumin and hippocalcin expression during ischemic brain injury and glutamate toxicity-induced neuronal cell death. Focal brain ischemia was induced in male Sprague-Dawley rats by middle cerebral artery occlusion (MCAO). Rats were treated with H2O or HRW (6 ml/kg per rat) before and after MCAO, and cerebral cortical tissues were collected 1, 7 and 14 days after MCAO. Based on our results, HRW treatment was able to reduce brain infarct volume and improve neurological function following ischemic brain injury. In addition, HRW prevented the ischemia-induced reduction of parvalbumin and hippocalcin levels in vivo and also reduced the glutamate toxicity-induced death of neurons, including the dose-dependent reduction of glutamate toxicity-associated proteins in vitro. Moreover, HRW attenuated the glutamate toxicity-induced elevate in intracellular Ca(2+) levels. All these results suggest that HRW could protect against ischemic brain injury and that the maintenance of parvalbumin and hippocalcin levels by HRW during ischemic brain injury might contribute to the neuroprotective effects against neuron damage.
journal_name
Brain Resjournal_title
Brain researchauthors
Han L,Tian R,Yan H,Pei L,Hou Z,Hao S,Li YV,Tian Q,Liu B,Zhang Qdoi
10.1016/j.brainres.2015.04.038subject
Has Abstractpub_date
2015-07-30 00:00:00pages
129-138eissn
0006-8993issn
1872-6240pii
S0006-8993(15)00334-0journal_volume
1615pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In alert cats, extracellular spikes of neurons in the medial pontine tegmentum were recorded simultaneously with whole nerve discharges of the abducens and medial rectus nerves during horizontal vestibular nystagmus. Nystagmus-related neurons were classified by their firing patterns in relation to the abrupt cessation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90941-0
更新日期：1981-10-05 00:00:00
abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91274-v
更新日期：1993-08-06 00:00:00
abstract：:The effect of 4-aminopyridine (4-AP) on the release of labeled transmitters in mouse brain synaptosomes was studied in a superfusion system. 4-AP at microM concentrations notably stimulated the spontaneous release of labeled GABA and glutamate, and of acetylcholine (ACh) derived from tritiated choline. No effects on t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90423-1
更新日期：1982-11-04 00:00:00
abstract：:Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90510-5
更新日期：1987-11-10 00:00:00
abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90342-7
更新日期：1992-05-22 00:00:00
abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90712-6
更新日期：1983-09-12 00:00:00
abstract：:The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90784-6
更新日期：1994-12-15 00:00:00
abstract：:The possible involvement of catecholamines in the regulation of serotonin N-acetyltransferase (NAT) activity in retina of the African clawed frog was investigated using an in vitro eye cup preparation. Dopamine (10 microM) and norepinephrine (50 microM) had no significant effect on NAT activity of eye cups incubated i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90525-1
更新日期：1986-03-26 00:00:00
abstract：:Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90027-3
更新日期：1988-06-14 00:00:00
abstract：:The distribution and subcellular localization of AH9 antigen, recognized by a monoclonal antibody AH9, were examined in rat brain. Highest expression was observed in the lamina lucidum of the dentate gyrus of the rat hippocampus. Synaptic subfields of other limbic areas also expressed AH9 antigen at a substantial leve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01344-x
更新日期：1996-05-06 00:00:00
abstract：:Chronic food restriction lowers the threshold for lateral hypothalamic electrical self-stimulation (LHSS). This effect has previously been interpreted to reflect a sensitization of reward. In the present study a curve-shift method was used to explicitly differentiate effects of food restriction on brain stimulation re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00764-h
更新日期：1995-10-16 00:00:00
abstract：:High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90140-4
更新日期：1985-04-29 00:00:00
abstract：:The entire set of giant interneurons (GIs) in the nerve cord of the cockroach, Periplaneta americana, was ablated using either electrolytic or surgical techniques. All animals with these lesions were capable of turning and running away from standard wind puffs. However, all animals responded much less frequently to st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91202-4
更新日期：1988-04-05 00:00:00
abstract：:The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03160-8
更新日期：2002-09-13 00:00:00
abstract：:Inhibition of nitric oxide (NO) synthesis has been found to produce learning deficits in spatial tasks. Recent studies also suggest a regulatory effect of endogenous NO on hippocampal serotonin (5-HT) release and have shown that NO-synthase (NOS) inhibitors increased extracellular levels of serotonin (5-HT) in the rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03987-2
更新日期：2003-02-14 00:00:00
abstract：:The cholinergic neurotoxin, AF64A-picrylsulfonate, was unilaterally infused into the dorsal hippocampus of Wistar rats (2 nmol/2 microliters/4 min; A 6.2, Ls 1.5, H 6.5, Paxinos and Watson). After 19 days the for immunohistochemical staining of choline acetyltransferase (ChAT). Morphometry and counting of ChAT-immunor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91125-x
更新日期：1986-04-02 00:00:00
abstract：:Effect of a mu-opioid agonist (D-Ala2,N-MePhe4,Gly5-ol-enkephalin, DAGO), on glycine (Gly)-induced chloride current (IGly) was investigated in the periaqueductal gray (PAG) neurons acutely dissociated 1-2-week-old Wistar rats by the use of nystatin-perforated patch recording configuration under voltage-clamp condition...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:It has been demonstrated previously that kappa opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether kappa agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localizat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02154-0
更新日期：2001-04-13 00:00:00
abstract：:In view of the inconclusive findings relating the nuclei of the mammillary bodies (MB) with spatial memory, we evaluated the oxidative metabolic activity of the medial and lateral nuclei of the mammillary bodies (MB) after training young rats (30 days) of both sexes in the Morris water maze. Different groups were trai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.025
更新日期：2004-06-11 00:00:00
abstract：:Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.041
更新日期：2019-06-01 00:00:00
abstract：:To date, few treatment strategies applying cellular transplantation to the chronically injured spinal cord have yielded significant functional improvement in animal experiments. Here we report that significant improvement of locomotor function was achieved in rats with chronic spinal cord injury (SCI) by the applicati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.054
更新日期：2012-05-25 00:00:00
abstract：:The present study is a determination of the numbers of axons in the sural nerve and nerve to the medial gastrocnemius muscle following section and regeneration of the sciatic nerve in the rat. The data indicate that there is a significant increase in both myelinated and unmyelinated axons in the nerve to the medial ga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90819-9
更新日期：1984-03-12 00:00:00
abstract：:Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02542-8
更新日期：2002-05-17 00:00:00
abstract：:Buffy coat of three members from a family with Alzheimer's disease was inoculated into hamster brains. Eighteen months after the inoculation, all experimental animals were sacrificed for the neuropathological study. Hematoxylin-eosin staining showed no gross vacuolar degeneration, or neuronal loss in the cortex. The s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90949-v
更新日期：1991-06-14 00:00:00
abstract：:Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90515-5
更新日期：1989-05-08 00:00:00
abstract：:Sex differences in cocaine's mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.060
更新日期：2013-07-03 00:00:00
abstract：:Little is known about the association between brain white matter (WM) structure and motor function in humans. This study investigated complexity of brain WM interior shape as determined by magnetic resonance imaging (MRI) and its relationship with upper-extremity (UE) motor function in patients post stroke. We hypothe...
journal_title：Brain research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.brainres.2008.06.008
更新日期：2008-09-04 00:00:00
abstract：:The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.065
更新日期：2007-08-13 00:00:00
abstract：:The effects of acute opiate receptor stimulation on regional cerebral oxygen consumption and blood flow were examined in 9 regions of the artificially respired, alpha-chloralose-anesthetized cat. Regional cerebral arterial and venous oxygen saturation were examined microspectrophotometrically and regional cerebral blo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91262-9
更新日期：1984-01-23 00:00:00
abstract：:Numerous studies have suggested that nitric oxide (NO) in the nucleus tractus solitarii (NTS) participates in modulating cardiovascular function. Nitric oxide synthase (NOS), the enzyme responsible for synthesis of NO, exists in 3 isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). Althoug...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.057
更新日期：2007-09-26 00:00:00
