Immunohistochemical evidence for degeneration of cholinergic neurons in the forebrain of the rat following injection of AF64A-picrylsulfonate into the dorsal hippocampus.

abstract：:Classical anatomical depictions of the cervical sympathetic trunk label it as a cholinergic preganglionic structure. We studied the cervical sympathetic trunk of the rat following daily injection for 5 weeks of guanethidine monosulphate, a regimen known to selectively destroy adrenergic neurons outside of the blood-br...

journal_title：Brain research

authors： Zochodne DW,Low PA,Dyck PJ

更新日期：1989-10-02 00:00:00

abstract：:This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...

journal_title：Brain research

authors： Foster TC,Fugger HN,Cunningham SG

更新日期：2000-07-14 00:00:00

abstract：:Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat spinal cord. Where...

journal_title：Brain research

authors： Bourgoin S,Pohl M,Benoliel JJ,Mauborgne A,Collin E,Hamon M,Cesselin F

更新日期：1992-06-26 00:00:00

abstract：:Extracellular recordings were carried out in the primary visual cortex of behaving monkeys. Neurons were activated by moving a visual stimulus on their receptive fields during periods of steady fixation and by moving their receptive fields (smooth pursuit eye movements) on a motionless visual stimulus. Regarding non-o...

journal_title：Brain research

authors： Galletti C,Squatrito S,Battaglini PP,Maioli MG

更新日期：1983-01-31 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) controls protein translation and has an important role in the mechanism of pain hypersensitivity under persistent pain conditions. However, its expression and localization in pain-related regions of the nervous system is not completely understood. Here, we examined the expression a...

journal_title：Brain research

authors： Xu JT,Zhao X,Yaster M,Tao YX

更新日期：2010-06-08 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are readily accessible multipotent mesenchymal stem cells and are known to secrete multiple growth factors, and thereby to have cytoprotective effects in various injury models. In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorr...

journal_title：Brain research

authors： Kim JM,Lee ST,Chu K,Jung KH,Song EC,Kim SJ,Sinn DI,Kim JH,Park DK,Kang KM,Hyung Hong N,Park HK,Won CH,Kim KH,Kim M,Kun Lee S,Roh JK

更新日期：2007-12-05 00:00:00

abstract：:We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...

journal_title：Brain research

authors： Averill DB,Tsuchihashi T,Khosla MC,Ferrario CM

更新日期：1994-12-05 00:00:00

abstract：:Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 re...

journal_title：Brain research

authors： Briscoe RJ,Cabrera CL,Baird TJ,Rice KC,Woods JH

更新日期：2000-10-27 00:00:00

abstract：:While moderate calorie restriction (CR) in the absence of malnutrition has been consistently shown to have a systemic, beneficial effect against aging in several animals models, its effect on the brain microstructure in a non-human primate model remains to be studied using post-mortem histopathologic techniques. In th...

journal_title：Brain research

authors： Sridharan A,Pehar M,Salamat MS,Pugh TD,Bendlin BB,Willette AA,Anderson RM,Kemnitz JW,Colman RJ,Weindruch RH,Puglielli L,Johnson SC

更新日期：2013-05-01 00:00:00

abstract：:Percussion of the quadriceps tendon was used to test the hypothesis that knee extensor muscle spindle discharge initiates down-regulation of the gain of the soleus H reflex. Seven subjects participated. Soleus H reflex magnitude was observed for up to 15 s, following conditioning tendon taps of 60 N or 80 N force and ...

journal_title：Brain research

authors： Cheng J,Brooke JD,Staines WR,Misiaszek JE,Hoare J

更新日期：1995-05-29 00:00:00

abstract：:Brains of reptiles, Caiman crocodilus, were processed by standard immunocytochemical methodology using a polyclonal antibody to gamma-aminobutyric acid (GABA) raised in rabbit and a polyclonal antibody to glutamic acid decarboxylase (GAD) raised in sheep. No GABA(+) or GAD(+) cells or puncta were observed over any tha...

journal_title：Brain research

authors： Pritz MB,Stritzel ME

更新日期：1988-08-02 00:00:00

abstract：:An enriched environment has been shown to improve cognitive, behavioral and histopathological outcome after focal cerebral ischemia and head trauma. The purpose of this study was to determine the effect of an enriched environment on histopathology following global cerebral ischemia. Wistar rats (21 weeks of age) were ...

journal_title：Brain research

authors： Belayev A,Saul I,Liu Y,Zhao W,Ginsberg MD,Valdes MA,Busto R,Belayev L

更新日期：2003-02-21 00:00:00

abstract：:The effects of 2-day and 7-day cortisol treatment on immunoreactive corticotropin (ACTH) and beta-endorphin concentrations were measured in the cerebral cortex, hippocampus, hypothalamus, and cerebellum in male rats. Plasma ACTH, beta-endorphin, corticosterone, and cortisol levels were also measured in parallel. Corti...

journal_title：Brain research

authors： Bagdy G,Calogero AE,Chrousos GP,Szemeredi K

更新日期：1989-06-12 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg) on in vivo variations of monoamines was assessed in several brain regions. Administration of the cytokine provoked a modest increase of extracellular 5-HIAA and HVA from the nucleus accumbens, and 5-HIAA from the hippocampus. Following mild neurog...

journal_title：Brain research

authors： Merali Z,Lacosta S,Anisman H

更新日期：1997-07-04 00:00:00

abstract：:The discovery of glucagon biosynthesis and receptors within mammalian brain has led one to suspect a neurotransmitter role for glucagon. In order to address this hypothesis in birds, we investigated the existence of glucagon receptors in duck brain by radioligand binding on fresh tissue sections and radioautography. S...

journal_title：Brain research

authors： Montaron A,Moyse E,Barré H

更新日期：1994-11-07 00:00:00

abstract：:Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3-6 and 9-16. In both age groups, significant correlations were observed between membrane time constant ...

journal_title：Brain research

authors： Hochman S,Garraway SM,Pockett S

更新日期：1997-09-05 00:00:00

abstract：:Growth cones integrate a remarkably complex concert of chemical cues to guide axons to their appropriate destinations. Recent work suggests that integrins contribute to axon guidance by interacting with a wide range of extracellular molecules including axon guidance molecules, by mechanisms that are not fully understo...

journal_title：Brain research

authors： Lemons ML,Abanto ML,Dambrouskas N,Clements CC,Deloughery Z,Garozzo J,Condic ML

更新日期：2013-11-06 00:00:00

abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...

journal_title：Brain research

authors： Parsey RV,Oquendo MA,Simpson NR,Ogden RT,Van Heertum R,Arango V,Mann JJ

更新日期：2002-11-08 00:00:00

abstract：:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and P...

journal_title：Brain research

authors： Imamura A,Kamei A,Suzuki Y,Orii T,Takashima S

更新日期：1994-03-21 00:00:00

abstract：:The two primary categories of stroke, ischemic and hemorrhagic, both have fundamentally different mechanisms and thus different treatment options. These two stroke categories were applied to rat models to identify potential biomarkers that can distinguish between them. Ischemic stroke was induced by middle cerebral ar...

journal_title：Brain research

authors： Ren C,Zoltewicz S,Guingab-Cagmat J,Anagli J,Gao M,Hafeez A,Li N,Cao J,Geng X,Kobeissy F,Mondello S,Larner SF,Hayes RL,Ji X,Ding Y

更新日期：2013-12-02 00:00:00

abstract：:Slices of rat hippocampus were exposed to 700 MHz continuous wave radiofrequency (RF) fields (25.2-71.0 V m(-1), 5-15 min exposure) in a stripline waveguide. At low field intensities, the predominant effect on the electrically evoked field potential in CA1 was a potentiation of the amplitude of the population spike by...

journal_title：Brain research

authors： Tattersall JE,Scott IR,Wood SJ,Nettell JJ,Bevir MK,Wang Z,Somasiri NP,Chen X

更新日期：2001-06-15 00:00:00

abstract：:The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fac...

journal_title：Brain research

authors： Britt MD,Wise RA

更新日期：1983-01-03 00:00:00

abstract：:Manganese (Mn) is an essential trace element required for ubiquitous enzymatic reactions. Chronic overexposure to this metal may, however, promote potent neurotoxic effects. The mechanism of Mn toxicity is not well established, but several studies indicate that oxidative stress and mitochondria play major roles in the...

journal_title：Brain research

authors： Marreilha dos Santos AP,Santos D,Au C,Milatovic D,Aschner M,Batoréu MC

更新日期：2008-10-21 00:00:00

abstract：:High-intensity stimulation of the supraorbital region elicits, together with a blink reflex, a reflex inhibition of the jaw-closing muscles in normal man. The response differs from the well known inhibition obtained by intra- and perioral stimulation in two main features. Firstly, it consists of a single late silent p...

journal_title：Brain research

authors： Cruccu G,Agostino R,Lahuerta J,Manfredi M

更新日期：1986-04-23 00:00:00

abstract：:Microinjection of bicuculline (Bic) into the unilateral putamen (Put) of the cat resulted in periodic occurrence of contralateral movement of the head (dystonia). Corresponding to this dystonic movement, repetitive spikes of the field potential occurring in the Put of the injected side and strong inhibition of the ext...

journal_title：Brain research

authors： Yamada H,Fujimoto K,Yoshida M

更新日期：1995-04-24 00:00:00

abstract：:Previous studies have demonstrated that punctate injections of 6-hydroxydopamine (6-OHDA) into structures along the ventral lamina terminalis reduce drinking responses elicited by angiotensin II (ANG II). The purpose of the present study was to extend these findings by quantifying the catecholamine depletions that are...

journal_title：Brain research

authors： Cunningham JT,Johnson AK

更新日期：1989-02-20 00:00:00

abstract：UNLABELLED:The effects of acute and chronic exposure to phencyclidine (PCP) on the regulation of prolactin (PRL) secretion were examined. Female Sprague-Dawley rats were injected with PCP (10 mg/kg) or saline for 14 days, or just prior to the administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP). A sin...

journal_title：Brain research

authors： Hyde JF

更新日期：1992-02-28 00:00:00

abstract：:Mice lacking the GABA(A) receptor beta(3) subunit exhibit a profound disruption in thalamic circuitry. We have studied sleep in these mice under baseline conditions and following treatment with the benzodiazepine midazolam. Under baseline conditions, NREM sleep time did not differ between beta(3) subunit knockout mice...

journal_title：Brain research

authors： Wisor JP,DeLorey TM,Homanics GE,Edgar DM

更新日期：2002-11-15 00:00:00

abstract：:The current study examined the effects of intracerebroventricular (icv) infused aminopeptidase-resistant analogs of angiotensin II (AngII) and angiotensin III (AngIII) on thirst and sodium appetite. The analogs, [D-Asp1D-Arg2]AngII and [D-Arg1]AngIII, were further protected from degradation by pretreatment with the am...

journal_title：Brain research

authors： Wilson WL,Roques BP,Llorens-Cortes C,Speth RC,Harding JW,Wright JW

更新日期：2005-10-26 00:00:00

abstract：:This study investigated the effects of electrical stimulation with theta burst stimulation (eTBS) on seizure suppression. Optimal parameters of eTBS were determined through open-loop stimulation experiments and then implemented in a close-loop seizure control system. For the experiments, 4-aminopyridine (4-AP) was inj...

journal_title：Brain research

authors： Siah BH,Chiang CC,Ju MS,Lin CC

更新日期：2014-12-17 00:00:00