Abstract:
:Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the proliferation of the 4-12-week-old rat forebrain subependymal layer. We found that naltrexone, when given daily throughout the weaning period, evoked a long-lasting increase of the mitotic rate and the [3H]thymidine labelling index. This effect was most significant about 8-10 weeks after ending the naltrexone treatment. Although a direct influence of naltrexone on long-term subependymal cell proliferation cannot be excluded, we are discussing evidence of an indirect effect via suppression of noradrenergic activity in the forebrain.
journal_name
Brain Resjournal_title
Brain researchauthors
Schmahl W,Funk R,Miaskowski U,Plendl Jdoi
10.1016/0006-8993(89)90515-5subject
Has Abstractpub_date
1989-05-08 00:00:00pages
297-300issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90515-5journal_volume
486pub_type
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