Abstract：
:Sex differences in cocaine's mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry underlying cocaine environmental associations are sexually dimorphic. We used a standard 4 day conditioned place preference (CPP) paradigm using 20mg/kg cocaine-a dose that induced CPP in male and female Fischer rats. In the nucleus accumbens (NAc) following CPP expression, cocaine treated animals showed increased phosphorylated ERK (pERK), phosphorylated CREB (pCREB) and ΔFosB protein levels. In the hippocampus (HIP) and caudate putamen (CPu), pERK and FosB/ΔFosB levels were also increased, respectively. Cocaine females had a larger change in HIP pERK and CPu ΔFosB levels than cocaine males; partly due to lower protein levels in saline female rats when compared to saline males. Prefrontal cortex (PfC) pCREB levels increased in cocaine males, but not females, whereas PfC pERK levels were increased in cocaine females, but not males. CPP scores were positively correlated to NAc pERK, HIP pERK and CPu FosB protein levels, suggesting that similar to males, the ERK/CREB intracellular pathway in mesocorticolimbic regions undergoes cocaine induced neuroplasticity in female rats. However, there seem to be intrinsic (basal) sexual dimorphisms in this pathway that may contribute to responses expressed after cocaine-CPP. Taken together, our results suggest that cellular responses associated with the expression of learned drug-environment associations may play an important role in sex differences in cocaine addiction and relapse.
journal_name
Brain Resjournal_title
Brain researchauthors
Nygard SK,Klambatsen A,Hazim R,Eltareb MH,Blank JC,Chang AJ,Quinones-Jenab V,Jenab Sdoi
10.1016/j.brainres.2013.04.060subject
Has Abstractpub_date
2013-07-03 00:00:00pages
121-33eissn
0006-8993issn
1872-6240pii
S0006-8993(13)00645-8journal_volume
1520pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Early brain injury (EBI) refers to the direct injury to the brain during the first 72 h after subarachnoid hemorrhage (SAH), which is one of the major causes for the poor clinical outcome after SAH. In this study, we investigated the effect and the related mechanism of Salvinorin A (SA), a selective kappa opioid recep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.026
更新日期：2019-09-15 00:00:00
abstract：:We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02238-6
更新日期：2000-01-10 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target gene expression, and play an important role in cerebral ischemic injury. MiR-146a has been reported to be highly related to cell invasion, metastasis, immunity, inflammation and apoptosis. Previous studies have indicated that miR-146a can ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.034
更新日期：2016-10-01 00:00:00
abstract：:Most functional neuroimaging techniques rely on activation-flow coupling (AFC) to detect changes in regional brain function, but AFC responses may also be altered during pathophysiological conditions such as ischemia. To define the relationship between progressive ischemia and the AFC response, graded levels of cerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.024
更新日期：2005-06-14 00:00:00
abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90105-7
更新日期：1979-07-13 00:00:00
abstract：:Intrinsic membrane properties, voltage-dependent sodium and voltage-dependent potassium currents of area postrema neurons in culture have been characterized with respect to their voltage dependence, time dependence and sensitivity to specific blocking agents. The area postrema is a hindbrain circumventricular organ wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01159-5
更新日期：1995-12-24 00:00:00
abstract：:The regulation of spike generation in rat midbrain dopamine (DA) neurons was investigated using in vitro intracellular recordings. DA neurons fired long (greater than 1.8 ms) action potentials that exhibited comparatively depolarized spike thresholds (approx. -35 to -45 mV). Depolarization of the DA neuron increased t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90488-w
更新日期：1990-07-30 00:00:00
abstract：:Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise effects have not yet been determined. Voltage-dependent Ca2+ ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.060
更新日期：2006-09-19 00:00:00
abstract：:Power spectral analysis of the electroencephalogram (EEG) is a non-invasive method to examine infant brain maturation. Preterm fetal growth restricted (p-FGR) neonates display an altered EEG power spectrum compared to appropriate-for-gestational-age (AGA) peers, suggesting delayed brain maturation. Longitudinal studie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.010
更新日期：2018-01-01 00:00:00
abstract：:Zebrafish as a neurogenetic model system depends on the correct neuroanatomical understanding of its brain organization. Here, we address the unresolved question regarding a possible zebrafish homologue of the dorsal pallial division, the region that in mammals gives rise to the isocortex. Analyzing the distributions ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.089
更新日期：2011-03-24 00:00:00
abstract：:Molecular events associated with mnemonic processes and neuronal plasticity are postulated to result in functional changes in synaptic structure. One possible site is the post-synaptic density, where activity-dependent changes modulate signal transduction cascades. In this report, we detail spatial-temporal changes fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.023
更新日期：2005-04-18 00:00:00
abstract：:We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146347
更新日期：2019-10-15 00:00:00
abstract：:The intracellular free Ca2+ concentration ([Ca2+]i) of the bullfrog sympathetic ganglion cell was measured with fura-2 fluorescence under various conditions, and compared with changes in membrane potential recorded with an intracellular electrode. The [Ca2+]i was 109 nM on average under the resting condition and incre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91336-4
更新日期：1988-01-12 00:00:00
abstract：:Rapid skin indentations can produce strong tap-like sensations that contain little information about skin indentation depth. Although slower stimuli produce weaker sensations, subjects can more accurately identify how the position of the skin surface changes with respect to the deeper tissues. This dissociation betwee...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90609-7
更新日期：1984-09-10 00:00:00
abstract：:The density of binding sites for excitatory amino acids in the hippocampus of SDAT (senile dementia of the Alzheimer type) patients has been investigated. This was compared to that found in younger and old non-dement cases. In the SDAT hippocampi there was a significant decrease in the glutamate and kainate binding. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90706-8
更新日期：1988-08-09 00:00:00
abstract：:α4βδ GABA(A) receptors (GABARs) have low CNS expression, but their expression is increased by 48h exposure to the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one). THP also increases the efficacy of δ-containing GABARs acutely, where GABA is a partial agonist. Thus, we examined effects of THP (100 nM) and full GABA agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.047
更新日期：2012-06-29 00:00:00
abstract：:The efficacy of 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-Androstanediol; 3 alpha-Diol) and 4-pregnen-3,20-dione (progesterone; P) in promoting analgesia was investigated. Ovariectomized rats received daily injections of 3 alpha-Diol (0.6, 3.0, 6.0 and 7.5 mg/kg) or vehicle and twice daily injections of estradi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01118-8
更新日期：1996-02-12 00:00:00
abstract：:The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90427-3
更新日期：1981-12-28 00:00:00
abstract：:The dynamics of regional cerebral blood flow and brain extracellular glucose were studied in the freely moving rat. These two variables were measured in the striatum during and following both mild tail pinch and restraint stress. Blood flow was monitored using a refinement of the hydrogen clearance technique that allo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90373-u
更新日期：1993-02-26 00:00:00
abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.101
更新日期：2011-03-22 00:00:00
abstract：:The distribution of cerebellar [3H]flunitrazepam binding sites was studied autoradiographically in Purkinje cell degeneration (pcd/pcd), weaver (wv/wv), staggerer (sg/sg) and reeler (rl/rl) mutant mice. In the normal 78-day-old C57BL/6J mouse cerebellum, the highest concentration of [3H]flunitrazepam binding sites was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90920-1
更新日期：1988-03-15 00:00:00
abstract：:Explosive running is a reliable initial component of audiogenic seizures (AS) induced by acoustic stimulation in genetically prone rodents. This profound locomotor activation is usually considered as a convulsive manifestation of AS although some studies attribute running to a panic-like response. Increase in central ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.017
更新日期：2007-05-07 00:00:00
abstract：:The effects of estrus and prolonged estradiol benzoate (EB) treatment on estrogen receptor-like immunoreactivity (ER-LI) were studied in the female Brazilian opossum (monodelphis domestica) brain. In general, both estrus animals and EB treated animals had reduced ER-LI in specific brain regions when compared to ovarie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90632-w
更新日期：1993-07-16 00:00:00
abstract：:We carried out ligand binding experiments on membranes from rat brain cortical grey matter using radioiodinated beta/A4 8-17, with non-specific binding determined by the addition of 10 microM unlabelled peptide. Specific, reversible binding amounted to 60-75% of total binding and showed a clear dependence on time, tem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90905-b
更新日期：1991-06-14 00:00:00
abstract：:A combination of electron microscopic autoradiography and immunocytochemistry was used to examine the connections between serotoninergic axons and dopaminergic neurons of the arcuate nucleus of the rat hypothalamus. The serotoninergic elements were identified after selective uptake of tritiated serotonin and the dopam...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90841-3
更新日期：1986-02-05 00:00:00
abstract：:The activity of 294 single units was recorded from the dorsolateral prefrontal cortex of monkeys performing two visual discrimination tasks with delayed response. One task, delayed matching-to-sample (DMS), required memory of a colored cue for later (18 s) matching and choice of color; the cue did not connote the loca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90436-2
更新日期：1988-12-06 00:00:00
abstract：:Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.06.029
更新日期：2010-08-12 00:00:00
abstract：:Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.005
更新日期：2007-07-16 00:00:00
abstract：:To examine whether the activation of brainstem neurons during ingestion is due to orosensory afferents or post-ingestive factors, neuronal activation in response to intraoral and intragastric infusions of taste stimuli was compared in the area postrema (AP), nucleus tractus solitarius (NTS) and parabrachial nucleus (P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02242-3
更新日期：2000-06-02 00:00:00
abstract：:Xenopus laevis tadpoles functionally recover from spinal cord transection. Because this recovery requires the tadpole to metamorphose, it may result from compensatory changes initiated by de novo growth of axons involved in limb dominant locomotion rather than from regeneration of cut axons. To determine whether axona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.126
更新日期：2006-05-09 00:00:00
