Involvement of the mammillary bodies in spatial working memory revealed by cytochrome oxidase activity.

Abstract:

:In view of the inconclusive findings relating the nuclei of the mammillary bodies (MB) with spatial memory, we evaluated the oxidative metabolic activity of the medial and lateral nuclei of the mammillary bodies (MB) after training young rats (30 days) of both sexes in the Morris water maze. Different groups were trained in spatial working (WM) or reference memory (RM) tasks, respectively. The corresponding naïve groups swam for the same amount of time as the trained groups but without the escape platform. Control groups were added that had not been manipulated in any way. No sex-related differences were detected in the working memory task although males exhibited better reference memory than females. Cytochrome oxidase (CO) activity, an endogenous metabolic marker for neuronal activity, was measured in all the groups. CO activity increased significantly in both MB nuclei of male and female rats only in the spatial working memory group. In addition, high CO activity in the lateral nucleus of the MB was linearly correlated with lower escape latencies in both sexes after training in the working memory task. No CO activity changes were found in the basolateral amygdala (BL) in any of the experimental groups. This nucleus was used as a control brain region because of its participation in emotional behavior. The results suggest a specific role of the MB nuclei in spatial working memory in both sexes.

journal_name

Brain Res

journal_title

Brain research

authors

Conejo NM,González-Pardo H,Vallejo G,Arias JL

doi

10.1016/j.brainres.2004.03.025

subject

Has Abstract

pub_date

2004-06-11 00:00:00

pages

107-14

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006899304004810

journal_volume

1011

pub_type

杂志文章
  • The involvement of dopamine D2 receptors, but not D3 or D4 receptors, in the rewarding effect of brain stimulation in the rat.

    abstract::To identify the subtype of dopamine receptors critically involved in the rewarding effect of brain stimulation, four dopamine antagonists were intracranially injected in 25 rats. The importance of dopamine D1 receptors had been demonstrated previously by using SCH 23390, a highly selective D1 antagonist. Rats were imp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00304-1

    authors: Nakajima S,Patterson RL

    更新日期:1997-06-20 00:00:00

  • Metabolic and behavioral deficits following a routine surgical procedure in rats.

    abstract::To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was asse...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.01.134

    authors: Frumberg DB,Fernando MS,Lee DE,Biegon A,Schiffer WK

    更新日期:2007-05-04 00:00:00

  • The morphogenesis of glutamic acid decarboxylase in the neostriatum of the cat: neuronal and ultrastructural localization.

    abstract::Correlative light and electron microscopic immunohistochemical methods were adapted for a descriptive analysis of the normal time course and pattern of expression and intraneuronal localization of the enzyme glutamic acid decarboxylase (GAD) in the neostriatum (Ns) of fetal, postnatal and adult cats. The differentiati...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90155-6

    authors: Fisher RS,Levine MS,Adinolfi AM,Hull CD,Buchwald NA

    更新日期:1987-06-01 00:00:00

  • Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2.

    abstract::Prostanoids in the central nervous system define an important linkage between blood pressure and hormonal responses to hypotension/ischemia. Prostaglandin endoperoxide synthase (PGHS)-2, the inducible isoform of this enzyme, is induced by cerebral hypoperfusion/ischemia. To investigate the mechanism of the PGHS-2 gene...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.08.033

    authors: Zhang D,Wood CE

    更新日期:2005-10-26 00:00:00

  • p75 and TrkA receptors are both required for uptake of NGF in adult sympathetic neurons: use of a novel fluorescent NGF conjugate.

    abstract::We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03099-2

    authors: Gatzinsky KP,Haugland RP,Thrasivoulou C,Orike N,Budi-Santoso AW,Cowen T

    更新日期:2001-11-30 00:00:00

  • Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.

    abstract::Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00751-3

    authors: Hayakawa T,Chang MC,Bell JM,Seeman R,Rapoport SI,Appel NM

    更新日期:1998-10-05 00:00:00

  • Regional effects of hypothyroidism on 5'-nucleotidase and cyclic nucleotide phosphohydrolase activities in developing rat brain.

    abstract::The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(83)90185-2

    authors: King RA,Smith RM,Dreosti IE

    更新日期:1983-04-01 00:00:00

  • Effects of heroin and cocaine on brain activity in rats using [1-14C]octanoate as a fast functional tracer.

    abstract::Brain activity was measured autoradiographically using [1-14C]octanoate (OCTO) as a fast functional tracer in rats receiving either saline, heroin or cocaine. Regional optical densities were normalized to a relative optical density index for comparisons of OCTO labeling between treatment groups. Heroin significantly i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91323-6

    authors: Trusk TC,Stein EA

    更新日期:1988-01-12 00:00:00

  • Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy.

    abstract::The development of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous system. The rat pilocarpine model of epilepsy was utilized to study persistent alterations in calcium/calmodulin-dependent kinase II (CaM kinase II) activity associated with epileptogenesis. CaM kinase II-dependen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02623-8

    authors: Churn SB,Kochan LD,DeLorenzo RJ

    更新日期:2000-09-01 00:00:00

  • Direct parabrachial nuclear projections to the pharyngeal motoneurons in the rat: an anterograde and retrograde double-labeling study.

    abstract::The parabrachial nucleus consists of several subnuclei which contains autonomic, gustatory, visceral sensory, nociceptive, and respiratory related neurons. We have investigated the direct projections from the rat parabrachial region, including the K olliker-Fuse nucleus, to the pharyngeal motoneurons with an anterogra...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01127-5

    authors: Hayakawa T,Zheng JQ,Seki M

    更新日期:1999-01-23 00:00:00

  • Transient elevation of intrasynaptosomal free calcium by putrescine.

    abstract::The role of polyamines in the regulation of free intrasynaptosomal Ca2+, [Ca2+]i was studied. After preincubation of rat brain synaptosomes with 5 mM difluormethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the K+-induced increase of [Ca2+]i was 33% less than that in non-treated synaptosome...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91162-0

    authors: Komulainen H,Bondy SC

    更新日期:1987-01-13 00:00:00

  • The influx of Ca2+ and the release of noradrenaline evoked by the stimulation of presynaptic nicotinic receptors of chick sympathetic neurons in culture are not mediated via L-, N-, or P-type calcium channels.

    abstract::We have shown earlier that nicotinic agonists induce the release of noradrenaline from chick sympathetic neurons in culture in two ways: (a) by activating the postsynaptic nicotinic receptors on nerve cell bodies, giving rise to spreading electrical activity and opening of voltage operated calcium channels in neuronal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)00876-1

    authors: Dolezal V,Lee K,Schobert A,Hertting G

    更新日期:1996-11-18 00:00:00

  • Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.

    abstract::We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01563-1

    authors: Boraud T,Bezard E,Guehl D,Bioulac B,Gross C

    更新日期:1998-03-16 00:00:00

  • Loss and displacement of ganglion cells after optic nerve regeneration in adult Rana pipiens.

    abstract::After studying pathway selection in the brain of Rana pipiens during unilateral optic nerve regeneration, several frogs were allowed to survive for lengthy periods for use in the present investigation. Retina flat-mounts were prepared from both eyes at 42-50 weeks postoperation. In some cases, HRP was infiltrated into...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90804-2

    authors: Scalia F,Arango V,Singman EL

    更新日期:1985-10-07 00:00:00

  • Distribution of bismuth in the brain after intraperitoneal dosing of bismuth subnitrate in mice: implications for routes of entry of xenobiotic metals into the brain.

    abstract::Bismuth (Bi) can produce neurotoxic effects in both humans and animals under certain dosing conditions, but little else is known about the effects of Bi in the brain. In the present study we determined the distribution of Bi in the brains of adult female Swiss-Webster mice 4, 7, 14, 21 and 28 days after a single 2500 ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00146-1

    authors: Ross JF,Switzer RC,Poston MR,Lawhorn GT

    更新日期:1996-07-01 00:00:00

  • Responses of neurons in the lateral thalamus of the cat to stimulation of urinary bladder, colon, esophagus, and skin.

    abstract::In seven female alpha-chloralose-anesthetized cats, 52 lateral thalamic neurons were tested with noxious distension of the urinary bladder, the distal colon and the lower esophagus. In addition, the neurons were characterized with innocuous and noxious mechanical stimulation of the skin and deep structures. Of the 52 ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02180-0

    authors: Horn AC,Vahle-Hinz C,Brüggemann J,Petersen M,Kniffki KD

    更新日期:1999-12-18 00:00:00

  • A newly synthesized neurotropic pyrimidine compound, MS-818, may activate migratory schwann cells in peripheral nerve regeneration.

    abstract::Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which mi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01491-1

    authors: Torigoe K,Awaya A

    更新日期:1998-03-23 00:00:00

  • Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia.

    abstract::The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.03.101

    authors: Kasahara Y,Taguchi A,Uno H,Nakano A,Nakagomi T,Hirose H,Stern DM,Matsuyama T

    更新日期:2010-06-22 00:00:00

  • Some connections of the area octavolateralis of Pleurodeles waltlii. A study with horseradish peroxidase under in vitro conditions.

    abstract::Horseradish peroxidase application in exsanguinated, pre-perfused newts, Pleurodeles waltlii, appeared to be very useful to study the connections of the area octavolateralis. Efferents from the octavolateral area course via bilateral lemnisci to the tectum and a presumptive torus semicircularis in the midbrain. Additi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90859-6

    authors: Gonzalez A,Munoz M

    更新日期:1987-10-13 00:00:00

  • Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue.

    abstract::Confocal microscopy and the Ca(2+)-sensitive fluorescent dye fluo-3 were used to study subcellular Ca2+ signals in embryonic, neonatal, and adult dorsal root ganglion (DRG) neurons in excised dorsal root ganglia. Optical images obtained from isolated whole embryonic and neonatal ganglia revealed a marked variability i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91444-3

    authors: Utzschneider DA,Rand MN,Waxman SG,Kocsis JD

    更新日期:1994-01-28 00:00:00

  • Gastric afferents project to the aldosterone-sensitive HSD2 neurons of the NTS.

    abstract::The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.08.098

    authors: Shin JW,Loewy AD

    更新日期:2009-12-08 00:00:00

  • NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons.

    abstract::Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02990-1

    authors: Schmachtenberg O,Diaz J,Bacigalupo J

    更新日期:2003-08-01 00:00:00

  • Potentiation of angiotensin II-induced drinking by glucocorticoids is a specific glucocorticoid type II receptor (GR)-mediated event.

    abstract::Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90093-b

    authors: Sumners C,Gault TR,Fregly MJ

    更新日期:1991-06-28 00:00:00

  • Load-dependent posterior-anterior shift in aging in complex visual selective attention situations.

    abstract::The cognitive reserve hypothesis proposes that the brain actively attempts to cope with age-related changes by using pre-existing cognitive networks (neural reserve) or enlisting compensatory processes (neural compensation). In a context of visual selective attention, the current study compared task-related activation...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.02.061

    authors: Ansado J,Monchi O,Ennabil N,Faure S,Joanette Y

    更新日期:2012-05-15 00:00:00

  • Effects of remote noxious stimulation on exteroceptive reflexes in human jaw-closing muscles.

    abstract::Reflexes evoked by applying non-painful taps to an incisor tooth were recorded from the jaw closing masseter and temporal muscles of 21 human subjects. A series of inhibitory, excitatory, inhibitory and excitatory waves (the 'Q, R, S and T' waves of the post-stimulus electromyographic complex (PSEC)) occurred in full-...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cadden SW,van der Glas HW,Lobbezoo F,van der Bilt A

    更新日期:1996-07-08 00:00:00

  • AP-1 inhibitory peptides attenuate in vitro cortical neuronal cell death induced by kainic acid.

    abstract::This study has assessed the neuroprotective efficacy of five AP-1 inhibitory peptides in an in vitro excitotoxicity model. The five AP-1 inhibitory peptides and controls of the JNK inhibitor peptide (JNKI-1D-TAT) and TAT cell-penetrating-peptide were administered to primary cortical neuronal cultures prior to kainic a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.09.007

    authors: Meade AJ,Meloni BP,Mastaglia FL,Watt PM,Knuckey NW

    更新日期:2010-11-11 00:00:00

  • Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress.

    abstract::Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.02.039

    authors: Pierce AN,Di Silvestro ER,Eller OC,Wang R,Ryals JM,Christianson JA

    更新日期:2016-05-15 00:00:00

  • Quantitative analysis of AMPA receptor subunit composition in addiction-related brain regions.

    abstract::The subunit composition of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) is an important determinant of AMPAR biophysical properties and trafficking. To date, AMPAR subunit composition has been quantitatively evaluated only for the hippocampus, where different experimental approaches have yield...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.10.016

    authors: Reimers JM,Milovanovic M,Wolf ME

    更新日期:2011-01-07 00:00:00

  • Left and right 6-hydroxydopamine lesions of the medial prefrontal cortex differentially alter subcortical dopamine utilization and the behavioral response to stress.

    abstract::The effects of left and right prefrontal cortical dopamine (DA) depletion on circling behavior, stress-escape behavior and subcortical DA function were examined in rats exhibiting left or right turning biases. 6-Hydroxydopamine lesions of the medial prefrontal cortex (PFC) caused significant DA depletions when assesse...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01290-7

    authors: Carlson JN,Visker KE,Keller RW Jr,Glick SD

    更新日期:1996-03-04 00:00:00

  • Three dimensional morphometric analyses of axon terminals early changes induced by methylmercury intoxication in the adult cat striate cortex.

    abstract::The aim of the present report is to investigate in detail morphometric changes of axon terminals of area 17 of adult cat induced by methylmercury intoxication. Six adult male cats (Felix catus), with 12 h day-light cycle and ad libitum water and food regimen, received a single dose of MeHgCl (6.4 mg/kg) dissolved in m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.09.036

    authors: de Oliveira RB,Gomes Leal W,Picanço-Diniz DL,Torres Neto JB,Lins N,Malm O,Picanço-Diniz CW

    更新日期:2008-12-09 00:00:00