Abstract：
:The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Sugimoto K,Abe K,Lee TH,Sakurai E,Yanai K,Kogure K,Itoyama Y,Watanabe Tdoi
10.1016/0006-8993(94)90784-6subject
Has Abstractpub_date
1994-12-15 00:00:00pages
279-83issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90784-6journal_volume
666pub_type
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