Abstract：
:The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fatty acids levels were also examined. Injections of 8-OH-DPAT evoked intense lipolytic and dipsogenic effects, but failed to affect feeding, non-ingestive behaviors and glycemic levels. On the other hand, GR46611 evoked significant increases in food intake (at the higher dose), as well as lipolytic and hyperglycemic effects, but left drinking and other non-ingestive behaviors unchanged. These effects are opposed to those found in rodents, and may be associated with the diverse, species-specific nature and distribution of these receptors, underscoring the need to examine the functional aspects of the 5-HT1 receptor family in a more extensive range of non-rodent species.
journal_name
Brain Resjournal_title
Brain researchauthors
Da Silva RA,de Oliveira ST,Hackl LP,Spilere CI,Faria MS,Marino-Neto J,Paschoalini MAdoi
10.1016/j.brainres.2004.08.031subject
Has Abstractpub_date
2004-11-12 00:00:00pages
275-83issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(04)01354-Xjournal_volume
1026pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The measurements of the ion conductances in molluscan somata, published by Connor and Stevens (1971), were converted into Hodgkin-Huxley like equations. The accuracy of these equations was shown with simulations. An advantage of these equations, compared to the original equations for the fast outward K+(A)-conductance...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90120-4
更新日期：1986-09-10 00:00:00
abstract：:Brain/kidney (B/K) protein is a new protein of 474 amino acids, which contains two C2 domains structurally homologous to those present in synaptotagmins. The expression of B/K protein was identified in the rat retina and B/K protein immunoreactivity was localized to a number of ganglion cells, a few amacrine cells and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02014-x
更新日期：2000-03-31 00:00:00
abstract：:During the middle of the subjective day, circadian activity rhythms in Syrian hamsters can be phase advanced by a variety of stimuli including microinjection of neuropeptide Y (NPY) or muscimol into the suprachiasmatic nucleus (SCN). It is not known, however, if these treatments shift activity rhythms by acting direct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00831-7
更新日期：1997-10-24 00:00:00
abstract：:Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning impairment attributable to intracellular soluble Aβ. We made a small inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.017
更新日期：2016-04-15 00:00:00
abstract：:The spinal cord dorsal horn contains neural mechanisms which can greatly facilitate pain. We have recently shown that 'illness'-inducing agents, such as intraperitoneally administered lipopolysaccharide (LPS; bacterial endotoxin), can produce prolonged hyperalgesia. This hyperalgesic state is mediated at the level of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91948-8
更新日期：1994-11-21 00:00:00
abstract：:Available studies indicate that the adrenergic stimulation of pineal cyclic GMP production involves stimulation of guanylyl cyclase activity by nitric oxide (NO) derived from arginine. This line of investigation was extended in the present study. Using a highly sensitive microassay, it was found that pineal NO synthas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90693-9
更新日期：1994-07-18 00:00:00
abstract：:Of 602 rats tested for amphetamine-induced or nocturnal rotation (circling behavior), 54.8% (P less than 0.025) had right side biases. Of 292 rats tested in two-lever operant situations, 57.5% (P less than 0.02) preferred the right lever. Right-biased rats were significantly more active and had stronger side preferenc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90737-x
更新日期：1981-01-26 00:00:00
abstract：:Accumulating evidence suggests that the neuropeptide substance P (SP) and its principal receptor neurokinin 1 (NK1) play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce thei...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2009.11.014
更新日期：2010-02-16 00:00:00
abstract：:Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01189-7
更新日期：1995-12-15 00:00:00
abstract：:The concentration of soluble glial fibrillary acidic (GFA) protein and the specific activity of glutamine synthetase (GS) were estimated in 11 central nervous system (CNS) regions of the 90-day-old rat. Marked differences were observed in the regional distribution of these astrocyte marker proteins. The striatum and s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90708-5
更新日期：1985-04-01 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target gene expression, and play an important role in cerebral ischemic injury. MiR-146a has been reported to be highly related to cell invasion, metastasis, immunity, inflammation and apoptosis. Previous studies have indicated that miR-146a can ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.034
更新日期：2016-10-01 00:00:00
abstract：:Radial glial cells of the embryonic murine cerebral wall are selectively labeled by staining with antibody RC1. In order to study the mitotic cycling of these cells, we combined RC1 immunohistochemistry and autoradiographic analysis following [3H]thymidine injection at 1, 2, 6, 48 h prior to sacrifice. Many radial gli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90043-0
更新日期：1988-02-01 00:00:00
abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90159-k
更新日期：1993-08-27 00:00:00
abstract：:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01307-4
更新日期：1995-01-23 00:00:00
abstract：:Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median eminence (turnover rate 1.62 +/- 0.36 pg/micrograms protein/h) rather...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90307-x
更新日期：1984-12-10 00:00:00
abstract：:The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00155-j
更新日期：1995-04-24 00:00:00
abstract：:The size differences in the midsagittal cerebellum, its individual lobules and its layers are studied in homozygous diabetic (HOM) and heterozygous Brattleboro rats on postnatal days 12, 24 and 180. As has been reported for total cerebellar weight, no significant reduction in cerebellar size in HOM rats occurs at day ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90296-8
更新日期：1986-05-01 00:00:00
abstract：:The present experiments were designed to assess whether brain hypothermia can reduce the behavioral and histopathological deficits associated with global forebrain ischemia. Animals were subjected to 12.5 min of four vessel occlusion (4VO) with moderate hypotension, and brain temperature maintained at either 37 degree...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90945-6
更新日期：1992-05-15 00:00:00
abstract：:Suppression of geniculate ponto-geniculo-occipital (PGO) waves was achieved in kittens by performing bilateral mesencephalic lesions of the PGO pathways. Sleep-wake parameters and the spontaneous unit activity in the lateral geniculate nucleus (LGN) were then chronically recorded during one month after the lesions. Wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90735-9
更新日期：1987-04-14 00:00:00
abstract：:The recent development of rodent models of bone cancer pain has started to provide the basis for demonstrating the particular neurochemical and behavioral entity of cancer pain. Behaviourally, both spontaneous pain and hyperalgesia related to mechanical, but not thermal, noxious stimuli have been described in cancer-b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02284-4
更新日期：2003-04-18 00:00:00
abstract：:The localization of the receptor for apamin, a specific toxin for one class of sensitive Ca2+-dependent K+ channel, was studied in rat brain using an in vitro autoradiographic technique. Radiolabeled monoiodoapamin binds specifically to rat brain sections with a high affinity (Kd = 25 pM) to a single class of sites. A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91333-8
更新日期：1986-09-24 00:00:00
abstract：:Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated ablation of astroglial cells in different parts of the nervous system. T...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/s0006-8993(99)01639-x
更新日期：1999-07-17 00:00:00
abstract：:Unilateral destruction of the entorhinal area in the rat results in the proliferation of a pathway from the surviving contralateral entorhinal area to the fascia dentata denervated by the lesions (the crossed temporodentate pathway). The present study analyzes the point of entry of these reinnervating fibers into the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90464-3
更新日期：1980-02-10 00:00:00
abstract：:Effects of pre-treatment of synaptic membranes with beta-adrenoceptor agonists and cholera toxin on [3H]clonidine and [3H]yohimbine binding were examined in rat cerebral cortex. Pre-incubation of cerebral cortical membranes with isoproterenol (10 or 200 microM) or dobutamine (1, 10 or 200 microM) at 37 degrees C for 4...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90531-1
更新日期：1985-03-11 00:00:00
abstract：:The effects of 2-day and 7-day cortisol treatment on immunoreactive corticotropin (ACTH) and beta-endorphin concentrations were measured in the cerebral cortex, hippocampus, hypothalamus, and cerebellum in male rats. Plasma ACTH, beta-endorphin, corticosterone, and cortisol levels were also measured in parallel. Corti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90853-6
更新日期：1989-06-12 00:00:00
abstract：:The activity of cerebellar Purkinje cells during controlled and passive movement of the forepaw was studied in the cat. Burst responses characteristic of activation by climbing fibers were observed in Purkinje cells in lobules Vb and Vc of the cerebellar vermis and paravermis. The climbing fiber responses followed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90069-x
更新日期：1976-04-16 00:00:00
abstract：:In rats raised from birth under a regular dark-light cycle, retinal dopamine (DA) levels were low at 12 days, increased progressively and steeply at 16, 20, 30 and 60 days and peaked at about 75 days postnatally. Dark-rearing from birth suppressed the magnitude of the normal developmental pattern of DA concentrations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90293-2
更新日期：1986-05-01 00:00:00
abstract：:The behavioral effects of lesions of the nucleus basalis magnocellularis (NBM) on two spatial discrimination tasks (place navigation and cross maze) were examined in the rat. These tasks were designed to test reference memory. Lesions by bilateral injection of ibotenic acid into the NBM led to a severe and permanent i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90079-0
更新日期：1988-07-12 00:00:00
abstract：:The suitability of (3H)DPCPX (8-cyclopentyl-1,3-dipropylxanthine), a xanthine derivative, as an vivo probe for labelling adenosine A1 receptors was studied in rats. [3H]DPCPX (nM) penetrated largely into the brain (0.8% of the injected dose per gram of brain tissue 5 min after injection). Brain concentrations stayed a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90845-z
更新日期：1992-12-18 00:00:00
abstract：:Weaver mutant mice alternated above chance levels but less often than normal mice in a 2-trial spontaneous alternation test. When the inter-trial (or retention) interval was manipulated, the weaver mutants alternated above chance levels only at the shortest (15 s) but not at the longest (4 or 5 min) intervals, contrar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91265-5
更新日期：1986-11-19 00:00:00
