Abstract:
:In rats raised from birth under a regular dark-light cycle, retinal dopamine (DA) levels were low at 12 days, increased progressively and steeply at 16, 20, 30 and 60 days and peaked at about 75 days postnatally. Dark-rearing from birth suppressed the magnitude of the normal developmental pattern of DA concentrations in retina and at 20, 30 and 60 days of age they were markedly smaller compared with those in age-matched controls grown under regular cyclic illumination. In adult rats reared up to the age of 60 days in regular cyclic lighting and then transferred to complete darkness for additional periods of 7-60 days, there were marked reductions in retinal DA levels. In rats reared in total darkness for 16, 20 or 30 days after birth and then transferred to regular dark-light conditions for additional periods of up to 30 or 60 days, retinal DA levels were always higher than those in animals with continuous light deprivation. They were similar to or even higher than those in rats grown under regular dark-light cycle. Findings suggest that light stimulation is essential for the postnatal ontogenetic increases of synthesis and storage of DA within retinal DAergic neurons. Suppressed DA accumulation in retina induced by dark-rearing from birth is not irreversible and can be completely corrected by re-exposure to regular lighting conditions regardless of the durations of postnatal light deprivation.
journal_name
Brain Resjournal_title
Brain researchauthors
Melamed E,Frucht Y,Vidauri J,Uzzan A,Rosenthal Jdoi
10.1016/0165-3806(86)90293-2subject
Has Abstractpub_date
1986-05-01 00:00:00pages
280-4issue
2eissn
0006-8993issn
1872-6240journal_volume
391pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Somatostatin-like immunoreactivity (Som-LI) and glycine high-affinity uptake have been characterized in the Rana pipiens retina. These labels are found in both the outer and inner plexiform layers (OPL and IPL), suggesting that interplexiform cells (IPCs) contain both Som and glycine in this retina. In double-label ex...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91215-8
更新日期:1989-08-21 00:00:00
abstract::Neurite formation in neurones isolated from adult molluscs in culture has been shown to depend on the total content of Ca in the cells, intracellular Ca2+ concentration, intracellular acid-alkaline balance, extracellular pH, and the capacity and composition of buffers. The neurones with a low total Ca content prior to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90546-2
更新日期:1983-10-03 00:00:00
abstract::Axon-to-myelin transfer of lipids precursors have been studied in the rabbit optic system by intraocular injection of [32P]orthophosphate, [14C]glycerol and [3H]glycerol. Choline and ethanolamine phosphoglycerides and myelin showed increasing [32P]-radioactivity between 7 and 21 days following injection, while [3H]- a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90136-1
更新日期:1983-06-20 00:00:00
abstract::Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selected drugs from two putative functional categories, Na+-channel ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.12.032
更新日期:2017-02-15 00:00:00
abstract::Compound action potential recording techniques were used to investigate the time- and frequency-dependent effects of 4-aminopyridine (4-AP) and tetraethylammonium (TEA) on large diameter, fast conducting (t1) and medium diameter, middle conducting (t2) optic tract axons in anesthetized hooded rats. Single-pulse studie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91102-5
更新日期:1989-10-02 00:00:00
abstract::The enzyme in brain that hydrolyzes 2',3'-cyclic nucleotides to the 2'-mononucleotides has been found by several authors to be concentrated in the myelin fraction. To facilitate further study of the enzyme, one of our objectives has been to develop a method of solubilizing the enzyme without the use of detergents. Whe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90719-2
更新日期:1975-05-23 00:00:00
abstract::Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02938-9
更新日期:2001-11-02 00:00:00
abstract::The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91476-w
更新日期:1990-07-09 00:00:00
abstract::Following the implantation of cobalt-gelatine pellets into the frontal cortex, epileptiform spikes in both primary and secondary foci developed and reached a peak between 7-12 days post implantation. Histological examination showed a necrotic lesion with terminal and fibre degeneration in brain areas connected with th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90288-7
更新日期:1975-07-25 00:00:00
abstract::Effects of intracellular accumulation of 3',5'-cyclic adenosine monophosphate (cAMP) were studied using 3',5'-cyclic 8-bromoadenosine monophosphate (8-Br-cAMP) and forskolin on single motoneurons acutely dissociated from adult bullfrog spinal cord. 8-Br-cAMP (10(-3) M) and forskolin (1.5 x 10(-6) M) activated inward c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90787-a
更新日期:1992-02-28 00:00:00
abstract::The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an orig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90788-o
更新日期:1993-04-09 00:00:00
abstract::Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90161-x
更新日期:1976-05-21 00:00:00
abstract::A push-pull perfusion technique was employed for in vivo study of adenosine 3',5'-monophosphate (cAMP) and guanosine 3',5'-monophosphate (cGMP) in the rat caudate nucleus. Addition of dopamine to the perfusion fluid elicited dose-dependent increases of both cAMP and cGMP perfusate concentrations. In separate experimen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90495-5
更新日期:1979-12-21 00:00:00
abstract::Fast B neurons in bullfrog sympathetic ganglia were voltage clamped with two microelectrodes. Acetylcholine (ACh) was applied onto the soma membrane by iontophoresis. A rapid nicotinic inward current was followed by a slow muscarinic inward current. After an addition of scopolamine to Ringer solution so as to block th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90987-9
更新日期:1984-03-19 00:00:00
abstract::In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00139-x
更新日期:1997-05-16 00:00:00
abstract::'Feedback' signals from mammalian extrastriate visual cortices are reported to exert primarily an excitatory influence on the classical receptive field (CRF) of neurons in the primary visual cortex (V1). However, given the much larger CRFs of neurons in extrastriate visual cortices it is not yet understood how feedbac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.069
更新日期:2010-04-30 00:00:00
abstract::Daily changes in tryptophan-5-hydroxylase (TrH) activity have been studied in six different 5-HT-containing cell groups (B3, B4, B5, B6, B7, B8,) in the brain stem of rats maintained in a regular cycle of 12 h of light and 12 h of darkness. Significant circadian alternations of TrH activity were observed in most of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90647-3
更新日期:1977-03-04 00:00:00
abstract::Glucocorticoids exacerbate aging-induced cell death, but relatively little is known about other CNS effects in senescence. We examined noradrenergic/adenylyl cyclase signaling in the cerebellum, which is a brain region that is susceptible to deterioration of synaptic function in aging. Aged control rats had increased ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00518-6
更新日期:1998-08-03 00:00:00
abstract::Thermoregulatory (brown adipose tissue temperature) experiments were conducted in age-matched anesthetized, male Sprague-Dawley and Long Evans rats kept at 37 degrees C given unilateral electrical stimulation of the ventromedial hypothalamic nucleus or the lateral preoptic area or after intravenous infusion of norepin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90422-6
更新日期:1992-03-13 00:00:00
abstract::In this study we compare the distribution of the phosphoprotein B-50 in two regions of immature and adult rat brain using affinity-purified antibodies to B-50. In the cerebellum of the 8-day-old rat we observed distinct patterns of distribution of B-50 immunoreactivity (BIR) in the premigratory zone and the developing...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90747-x
更新日期:1986-06-11 00:00:00
abstract::The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90395-4
更新日期:1981-12-28 00:00:00
abstract::The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.070
更新日期:2008-11-25 00:00:00
abstract::Fetal exposure to dexamethasone (DEX) alters brain plasticity and cognitive functions during adulthood in a sex-dependent manner. The mechanisms underlying such long-lasting sex-dependent change of prenatal DEX is not well understood. The p73 gene plays an important role in brain development. It encodes for two protei...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.11.030
更新日期:2019-03-15 00:00:00
abstract::Cortical superfusion with 6-aminomethyl-3-methyl, 1-4H-1,2,6-benzothiadiazine-1,1-diazide hydrocholoride (TAG) at a concentration which selectively blocks taurine (Tau) action fails to modify electroencephalographic (EEG) activity, cortical neuronal firing and caudate-induced inhibition of cortical neuronal activity. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91449-6
更新日期:1986-08-13 00:00:00
abstract::To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90214-6
更新日期:1981-09-07 00:00:00
abstract::Numerous studies of neonatal neuronal development in mammals have revealed that neuronal cell death following axotomy is apoptotic in nature. In adult animals, however, neuronal cell death following axonal injury may or may not exhibit features of apoptosis. Bcl-2 and Bax have been identified as inhibitor and promoter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01315-3
更新日期:1999-05-08 00:00:00
abstract::Pupil dilatation (PD) was produced by vaginocervical mechanical stimulation (VCMS) in intact rats, and in rats with spinal cord (SC) transection at level T7 (i.e., above the level of entry into SC of all genitospinal nerves). After transection of SC, bilateral vagotomy abolished PD in response to VCMS, providing evide...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.104
更新日期:2007-10-26 00:00:00
abstract::Our previous studies have indicated that oxygen radicals, produced during reoxygenation following short-term arterial hypoxia, lead to sustained suppression of cerebral arteriolar responses to N-methyl-D-aspartate (NMDA). However, whether arteriolar dilator responses to NMDA are reduced during arterial hypoxia has nev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01196-7
更新日期:1998-01-12 00:00:00
abstract::The action of 5-hydroxytryptamine (5-HT) via the 5-HT1A receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. Under voltage-clamp conditions, 5-HT induced an inwardly rectifying K+ current (I5-HT) in a concentration-dependen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01141-9
更新日期:1997-01-16 00:00:00
abstract::Experiments were conducted to (1) provide further evidence of the selectivity of [D-Ala2,Leu5,Cys6]enkephalin (DALCE) as an antagonist of delta (delta) receptor ligands and (2) use DALCE as a tool to explore the possible role of delta receptors in restraint stress. Dose- and time-response curves were generated for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90545-m
更新日期:1990-02-19 00:00:00