Abstract：
:Cortical superfusion with 6-aminomethyl-3-methyl, 1-4H-1,2,6-benzothiadiazine-1,1-diazide hydrocholoride (TAG) at a concentration which selectively blocks taurine (Tau) action fails to modify electroencephalographic (EEG) activity, cortical neuronal firing and caudate-induced inhibition of cortical neuronal activity. Higher concentrations of TAG increase neuronal firing rate and eventually induce EEG interictal spikes that can be suppressed by topical gamma-aminobutyric acid (GABA), but not by glycine or beta-alanine. Topical Tau consistently enhances the epileptiform activity. It is concluded that specific blockade of Tau does not affect any of the physiological function under observation and that the epileptogenic effect of TAG is due to its GABA antagonistic action.
journal_name
Brain Resjournal_title
Brain researchauthors
Fariello RG,Golden GT,Ente Pdoi
10.1016/0006-8993(86)91449-6subject
Has Abstractpub_date
1986-08-13 00:00:00pages
196-200issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91449-6journal_volume
380pub_type
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