Abstract：
:Unilateral olfactory nerve section was performed in the mouse. Three biochemical markers of the olfactory chemoreceptor neurons: carnosine, carnosine synthetase activity and the olfactory marker protein, were measured in the olfactory bulb and epithelium. Parallel observations were made by light microscopy as well as at the ultrastructural level. The specific biochemical markers decrease rapidly in both bulb and epithelium and reach a minimum by the end of the first week after surgery. They then slowly return to 80% of control values by one month. Carnosinase activity in epithelium was essentially unaffected. These biochemical observations coincide temporally with the onset of degenerative changes seen morphologically, in both the bulb and epithelium. The degenerative changes persist for up to two weeks in the bulb and for about one week in the epithelium. At this time basal cell division and differentiation begins in the epithelium with subsequent regrowth of olfactory axons into the glomerular layer of the olfactory bulb with ther reappearance of olfactory axon terminals. The temporal coincidence of these biochemical and morphological observations suggests they are manifestations of the same process, and is consistent with the idea that the olfactory chemoreceptor neurons are perhaps unique in being able to be replaced from undifferentiated stem cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Harding J,Graziadei PP,Monti Graziadei GA,Margolis FLdoi
10.1016/0006-8993(77)90703-xsubject
Has Abstractpub_date
1977-08-19 00:00:00pages
11-28issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(77)90703-Xjournal_volume
132pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.022
更新日期：2017-01-15 00:00:00
abstract：:The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.045
更新日期：2008-11-06 00:00:00
abstract：:High (2.5-5 micrograms) doses of ventral tegmental morphine, which normally facilitate brain stimulation reward, were found to cause a complete cessation of bar pressing for brainstem stimulation in animals pretreated with systemic pimozide (0.175-0.35 mg/kg). It was hypothesized that the behavioral failure was due to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91402-9
更新日期：1989-01-16 00:00:00
abstract：:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90185-6
更新日期：1994-02-04 00:00:00
abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01280-3
更新日期：1999-02-13 00:00:00
abstract：:The lateral tuberal nucleus (LTN) is a hypothalamic region that has been identified with certainty only in humans and primates. It is composed of three small round globular units which protrude the basal surface of the brain along the optic tract. The function of the LTN is unknown. Recently, a tiny, parvalbumin-posit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.093
更新日期：2007-03-30 00:00:00
abstract：:The present study examined the influences of dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of Sprague-Dawley rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA). It has been proposed that the neonatal 6-OHDA-lesioned rat could se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90305-3
更新日期：1989-10-23 00:00:00
abstract：:The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00155-j
更新日期：1995-04-24 00:00:00
abstract：:The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91158-9
更新日期：1987-01-13 00:00:00
abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.056
更新日期：2007-02-09 00:00:00
abstract：:An investigation of reflex responses of leg muscles to sural stimulation during stepping was performed on human subjects. Non-noxious electrical stimulation applied during the swing phase or the latter half of the stance phase produced a mixed increase and decrease of EMG activity in the hamstring muscles. No response...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90123-3
更新日期：1983-12-12 00:00:00
abstract：:The effects of bilateral intracranial injections of the D-1 dopamine receptor antagonist SCH 23390 HCl (0, 0.8, 1.6, 3.2, and 6.4 microgram total bilateral dose) administered into the dorsolateral bed nucleus of the stria terminalis (dlBNST) immediately prior to a 3 h intravenous cocaine self-administration session we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01190-6
更新日期：1998-02-16 00:00:00
abstract：:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90171-6
更新日期：1989-04-03 00:00:00
abstract：:Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.038
更新日期：2005-03-10 00:00:00
abstract：:Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine. Therefore, d-seri...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2011.05.039
更新日期：2011-07-15 00:00:00
abstract：:The aim of this study was to test the hypothesis that ATP elevates cytosolic free Ca2+ levels ([Ca2+]i) in myenteric neurons expressing the Ca2+ binding protein, calbindin-D28. A laser microbeam marked the location of cultured neurons on coverslips and provided unequivocal relocation of ATP-responsive neurons after im...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00280-6
更新日期：1996-07-01 00:00:00
abstract：:Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91673-5
更新日期：1990-10-01 00:00:00
abstract：:This study shows that the axons of some raphespinal sympathoinhibitory neurons projecting to the third thoracic spinal segment emit branches in the third-fourth cervical spinal segments of cats. This was demonstrated by using time-controlled collision of neuronal action potentials initiated by stimuli applied at these...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91417-5
更新日期：1988-02-16 00:00:00
abstract：:Brain capillaries form a selective interface, the blood-brain barrier (BBB), between the neural parenchyma and the blood. The factors which regulate this interface are poorly understood. Both the iris and retina possess vascular beds that express some BBB characteristics; therefore, they provide attractive models to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91323-k
更新日期：1993-12-03 00:00:00
abstract：:The present study compared Fos expression in identified hypothalamic magnocellular neurons in lactating and non-lactating female rats submitted to acute haemorrhage or 24 h of water deprivation, stimuli that induce the release of both oxytocin and vasopressin. Quantitative analysis of preparations doubly immunostained...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90809-5
更新日期：1994-10-31 00:00:00
abstract：:Infusion of carbachol into the lateral ventricles of rats at rates of 400 or 2000 ng/h for 6 h produced dose-related natriuresis, kaliuresis, and water drinking but no consumption of hypertonic NaCl solution. Electrolyte excretion and water intake were maximal during the first 2 h, and no further increases occurred af...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90593-1
更新日期：1985-04-22 00:00:00
abstract：:An effective animal model for elucidating the neurobiological basis of human smoking should simulate important aspects of this behavior. Therefore, a 23 h unlimited access nicotine self-administration model was used to compare inbred Lewis rats, which have a propensity to self-administer drugs of abuse, to inbred Fish...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03375-3
更新日期：2002-03-15 00:00:00
abstract：:Using a double-labelling procedure, morphological relationships existing between dopaminergic and indoleaminergic neuronal systems in the rat brain were investigated. First, thanks to a tryptamine (T) antiserum, we visualized this indoleamine in all mesencephalic regions and showed that the T-immunoreactivity (IR) see...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91182-g
更新日期：1990-03-26 00:00:00
abstract：:In the present study we examined the laminar distributions of four types of chemically defined subpopulations of non-principal neurons, that is, those immunoreactive for parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and somatostatin (SS), in the rat hippocampus, by estimating their approximate numeric...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00457-5
更新日期：1997-08-01 00:00:00
abstract：:Glia represents the most numerous group of nervous system cells and CNS development and function depend on glial cells. We developed a purified Muller glia culture to investigate the expression of several neurotransmitter markers on these cells, such as dopaminergic, cholinergic, GABAergic and peptidergic receptors or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.031
更新日期：2005-03-21 00:00:00
abstract：:Experiments have been performed on pentobarbitone anesthetized or decerebrated rats. The nature of the synchronous rhythmical activity which occurs in the inferior olive following the electrophoretic or systemic administration of harmaline, harmine, dihydro-beta-erythroidine and various other compounds, is described. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90471-6
更新日期：1976-01-23 00:00:00
abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus and located in many neuronal systems in both the central and peripheral nervous system. PACAP is also found in nerve fibers innervating the pineal gland, where it stimulates the secretion of the pinea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03127-5
更新日期：2003-09-12 00:00:00
abstract：:The expression of the neurofilament (NF) protein triplet (70, 150 and 200 k daltons (K)) was studied by immunofluorescence in two clones of murine C-1300 neuroblastoma. Clone 1 formed clumps of round cells with few processes, while in clone 2 the cells were more dispersed and extended many processes. In both clones se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90718-2
更新日期：1984-05-14 00:00:00
abstract：:Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and hi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.053
更新日期：2005-02-09 00:00:00
abstract：:Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes nociceptive afferent neurons through E-prostanoid (EP) receptors. In the central nervous system, PGE2 modulates pain sensitivity and contributes to th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147153
更新日期：2021-01-01 00:00:00
