Abstract：
:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced modulation of brain regions that project to dopamine neurons. To explore regional contributions of cocaine to dopamine signaling, we administered cocaine to the lateral or fourth ventricles and compared the effects on dopamine release in the nucleus accumbens evoked by electrical stimulation of the ventral tegmental area to that of systemically-delivered cocaine. Stimulation trains caused a sharp rise in dopamine followed by a slower return to baseline. The magnitude of dopamine release ([DA]max) as well as the latency to decay to fifty percent of the maximum (t(1/2); index of DAT activity) by each stimulation train were recorded. All routes of cocaine delivery caused an increase in [DA]max; only systemic cocaine caused an increase in t(1/2). Importantly, these data are the first to show that hindbrain (fourth ventricle)-delivered cocaine modulates phasic dopamine signaling. Fourth ventricular cocaine robustly increased cFos immunoreactivity in the nucleus of the solitary tract (NTS), suggesting a neural substrate for hindbrain cocaine-mediated effects on [DA]max. Together, the data demonstrate that cocaine-induced effects on phasic dopamine signaling are mediated via actions throughout the brain including the hindbrain.
journal_name
Brain Resjournal_title
Brain researchauthors
Gerth AI,Alhadeff AL,Grill HJ,Roitman MFdoi
10.1016/j.brainres.2016.10.022subject
Has Abstractpub_date
2017-01-15 00:00:00pages
252-260eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30726-0journal_volume
1655pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In the present investigation, electron probe X-ray microanalysis was used to characterize the effects of in vitro ouabain (2 mM) or anoxia on elemental composition (e.g. Na, K, Ca) and water content of rat peripheral (tibial) nerve myelinated axons and Schwann cells. Results showed that independent of axon size, both ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00855-k
更新日期：1995-10-02 00:00:00
abstract：:In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00649-0
更新日期：1998-09-14 00:00:00
abstract：:Inoculation of the tail base of rats with Mycobacterium butyricum led to an arthritic swelling and inflammation of the limbs which displayed a hyperalgesia to noxious pressure: these effects peaked at 3 weeks postinoculation. In vitro autoradiography of coronal sections of rat brain was used for a parallel determinati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90917-6
更新日期：1987-07-28 00:00:00
abstract：:Evidence from human and animal studies has shown that experiences of early attachment can influence brain development and structure. Adult attachment style develops from early attachment experiences. However, little is known about the relationship between gray matter volume and attachment style. Further, the structura...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.035
更新日期：2018-11-15 00:00:00
abstract：:Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selected drugs from two putative functional categories, Na+-channel ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.12.032
更新日期：2017-02-15 00:00:00
abstract：:We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00557-4
更新日期：1996-08-26 00:00:00
abstract：:The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.024
更新日期：2004-02-20 00:00:00
abstract：:The implantation of dopamine-rich mesencephalic grafts into the 6-hydroxydopamine (6-OHDA)-lesioned neostriatum of rats was accompanied by marked hyperinnervation by serotonin (5-HT) fibers. The purpose of this study was to examine the possibility that the graft-derived 5-HT hyperinnervation is governed by target-rela...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91667-4
更新日期：1992-10-02 00:00:00
abstract：:The present study has shown that after intravenous injection of [125I]NGF the time-course of appearance of radioactivity in all organs studied with the exception of sympathetic and sensory ganglia, roughly paralleled that of the blood. The highest levels were reached immediately after injection, after which the radioa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90530-8
更新日期：1976-06-11 00:00:00
abstract：:Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicucull...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90031-8
更新日期：1978-11-24 00:00:00
abstract：:Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91593-3
更新日期：1986-03-05 00:00:00
abstract：:The possible involvement of protein kinase A (PKA) in the muscarinic inhibition of the slow afterhyperpolarizing current (IAHP) was investigated in rat hippocampal pyramidal cells. IAHP was recorded using the whole cell method in hippocampal slices, and Rp-cAMPS, a PKA antagonist, was applied intracellularly. The inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90096-5
更新日期：1994-05-23 00:00:00
abstract：:Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00253-3
更新日期：1996-06-03 00:00:00
abstract：:Saccadic adaptation is the progressive correction of systematic saccade targeting errors. When a saccade to a particular target is adapted, saccades within a spatial window around the target, the adaptation field, are affected as a function of their distance from the adapted target. Furthermore, previous studies sugge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.040
更新日期：2007-10-03 00:00:00
abstract：:Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured pati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01410-j
更新日期：1995-02-20 00:00:00
abstract：:We measured the effects of acute or chronic administration of fenfluramine and phentermine, alone or in combination, on brain dopamine and serotonin release into striatal dialysates of freely moving rats. Samples collected every 30 min were assayed in a single run by high-pressure liquid chromatography. Acute or chron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01003-8
更新日期：1998-11-30 00:00:00
abstract：:Research supports the effectiveness of acupuncture for conditions such as chronic low back and knee pain. In a five-patient pilot study the modality also improved the symptoms of chemotherapy-induced neuropathic pain. Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.004
更新日期：2011-09-26 00:00:00
abstract：:In rats raised from birth under a regular dark-light cycle, retinal dopamine (DA) levels were low at 12 days, increased progressively and steeply at 16, 20, 30 and 60 days and peaked at about 75 days postnatally. Dark-rearing from birth suppressed the magnitude of the normal developmental pattern of DA concentrations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90293-2
更新日期：1986-05-01 00:00:00
abstract：:The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX , a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas tho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91357-x
更新日期：1984-05-21 00:00:00
abstract：:Molecular events associated with mnemonic processes and neuronal plasticity are postulated to result in functional changes in synaptic structure. One possible site is the post-synaptic density, where activity-dependent changes modulate signal transduction cascades. In this report, we detail spatial-temporal changes fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.023
更新日期：2005-04-18 00:00:00
abstract：:The influence of osmotic stimulation on the density of beta-adrenoceptor binding sites in the rat supraoptic nucleus (SON) was studied by quantitative autoradiography using 125I-cyanopindolol (ICYP). Increased density of beta-adrenoceptor binding sites was observed in osmotically stimulated rats and also after the sup...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91592-3
更新日期：1992-08-21 00:00:00
abstract：:Autism spectrum disorders (ASD) are associated with disturbances of neural connectivity. Functional connectivity between neural structures is typically examined within the context of a cognitive task, but also exists in the absence of a task (i.e., "rest"). Connectivity during rest is particularly active in a set of s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.057
更新日期：2010-02-08 00:00:00
abstract：:Pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse N1E-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungaro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90493-6
更新日期：1994-08-22 00:00:00
abstract：:Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.028
更新日期：2017-02-15 00:00:00
abstract：:Previous studies have suggested that cardiovascular responses elicited by injection of glycine into the nucleus tractus solitarii (NTS) depend upon interactions between glycinergic and cholinergic neuronal elements in NTS. Release of acetylcholine in response to glycine is one such interaction that has been shown in s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91789-2
更新日期：1994-07-11 00:00:00
abstract：:There are different kinds of visuomotor learnings. One of the most studied is error-based learning where the information about the sign and magnitude of the error is used to update the motor commands. However, there are other instances where subjects show visuomotor learning even if the use of error sign and magnitude...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.05.022
更新日期：2015-08-27 00:00:00
abstract：:The short term effects of spinal cord hemisection on protein synthesis in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of spinal cord. Animals were sacrificed 3, 6, or 13 days after hemisection. Two normal animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91046-5
更新日期：1976-07-23 00:00:00
abstract：:Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.012
更新日期：2015-04-24 00:00:00
abstract：:Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90195-x
更新日期：1982-08-01 00:00:00
abstract：:Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90697-t
更新日期：1991-01-18 00:00:00
