Abstract：
:We measured the effects of acute or chronic administration of fenfluramine and phentermine, alone or in combination, on brain dopamine and serotonin release into striatal dialysates of freely moving rats. Samples collected every 30 min were assayed in a single run by high-pressure liquid chromatography. Acute or chronic administration of fenfluramine (1 mg/kg, i.p.) did not significantly change dopamine concentrations in rat striatal dialysates, but increased those of serotonin by 182% (acute) and 124% (chronic). Phentermine (2 mg/kg, i.p.), on the other hand, significantly increased dopamine concentrations by 52% (acute) and 80% (chronic) without affecting those of serotonin. Administration of the drugs in combination (fenfluramine 1 mg/kg and phentermine 2 mg/kg) amplified the effects of each, increasing striatal dopamine concentrations by 209% (acute) and serotonin concentrations by 330% (acute) and 299% (chronic).
journal_name
Brain Resjournal_title
Brain researchauthors
Balcioglu A,Wurtman RJdoi
10.1016/s0006-8993(98)01003-8subject
Has Abstractpub_date
1998-11-30 00:00:00pages
67-72issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01003-8journal_volume
813pub_type
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