The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus.

Abstract:

:We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons.

journal_name

Brain Res

journal_title

Brain research

authors

Morales M,Battenberg E,de Lecea L,Bloom FE

doi

10.1016/0006-8993(96)00557-4

subject

Has Abstract

pub_date

1996-08-26 00:00:00

pages

199-202

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(96)00557-4

journal_volume

731

pub_type

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