Abstract:
:Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of betaAP in an in vivo animal model.
journal_name
Brain Resjournal_title
Brain researchauthors
Harkany T,Lengyel Z,Soós K,Penke B,Luiten PG,Gulya Kdoi
10.1016/0006-8993(95)00823-9subject
Has Abstractpub_date
1995-10-09 00:00:00pages
71-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)00823-9journal_volume
695pub_type
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