Cholinotoxic effects of beta-amyloid (1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis.

Abstract:

:Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral frontal cortices. Confirmation of these data with silver staining also revealed degeneration of the projective fibers of the nbm to the frontal cortex. These results demonstrate the cholinotoxicity of betaAP in an in vivo animal model.

journal_name

Brain Res

journal_title

Brain research

authors

Harkany T,Lengyel Z,Soós K,Penke B,Luiten PG,Gulya K

doi

10.1016/0006-8993(95)00823-9

subject

Has Abstract

pub_date

1995-10-09 00:00:00

pages

71-5

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00823-9

journal_volume

695

pub_type

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