Abstract：
:Insulin-like growth factor (IGF) II receptors were studied in human adult brain by using autoradiography with [125I]IGF-II. Receptors were found to be widely distributed throughout all neuronal regions. The highest densities were found in plexus choroideus, granular layer of the cerebellar cortex, gyrus dendatus and pyramidal layer of the hippocampus, striatum, and cerebral cortex. White matter was devoid of IGF-II receptors. We also examined [125I]IGF-II binding in six plaques of multiple sclerosis, which were characterized by a dense network of astrocytes. We were unable to detect IGF-II receptors in any of the astrogliotic plaques, suggesting that IGF-II receptors in human brain are not involved in astrogliosis. The regional variations in neuronal distribution of IGF-II receptors suggest involvement of IGF-II in functions associated with specific neuronal pathways.
journal_name
Brain Resjournal_title
Brain researchauthors
Wilczak N,De Bleser P,Luiten P,Geerts A,Teelken A,De Keyser Jdoi
10.1016/s0006-8993(00)02153-3subject
Has Abstractpub_date
2000-04-28 00:00:00pages
282-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02153-3journal_volume
863pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.021
更新日期：2006-11-06 00:00:00
abstract：:17β-Estradiol is a multi-active steroid that imparts neuroprotection via diverse mechanisms of action. However, its role as a neuroprotective agent after spinal cord injury (SCI), or the involvement of the estrogen receptor-alpha (ER-α) in locomotor recovery, is still a subject of much debate. In this study, we evalua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.03.002
更新日期：2014-05-02 00:00:00
abstract：:Previous research has shown that, in freely moving laboratory rats, the odors of benzyl alcohol, camphor, carvacrol, isopentenyl methyl sulfide, 2-propylthietane, salicylaldehyde, trimethylthiazoline, and xylene (plus other compounds) elicit high amplitude bursts of roughly 20-Hz waves (beta-waves) in the olfactory bu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03225-5
更新日期：2002-01-11 00:00:00
abstract：:Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are see...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90049-1
更新日期：1986-09-24 00:00:00
abstract：:We investigated the responses of putative aortic baroreceptor neurons to mechanical stimulation of their processes. Putative aortic baroreceptor neurons were identified by applying the carbocyanine dye DiI to the adventitia of the aortic arch of anesthetized rats. After at least 1 week, the nodose ganglia were removed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00153-4
更新日期：1997-05-16 00:00:00
abstract：:Rarely do we encounter a single odorant in our environment. Perception of odours, therefore, usually depends on the reception and neural processing of many components. However, little is known about how and where odour mixtures are processed. Evidence is presented here that suppression of one odour by another, a commo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90419-7
更新日期：1987-11-17 00:00:00
abstract：:This study investigated the effects of morphine microinjection into the nucleus raphe magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00659-3
更新日期：1998-08-24 00:00:00
abstract：:Variation in cell loss and mossy fiber reorganization was examined along the longitudinal axis of the dentate gyrus from temporal lobe epileptic (TLE) patients. Previous evidence has indicated that the anterior hippocampus is prone to seizure activity. We compared granule and hilar cell number in addition to Timm stai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00167-o
更新日期：1995-04-24 00:00:00
abstract：:In in vitro slices prepared from rat sensorimotor cortex, intracellular recordings were obtained from 107 layer V pyramidal neurons, subsequently injected with biocytin for morphological reconstruction. Of the 107 neurons, 59 (55.1%) were identified as adapting (45) or non-adapting (13) regular spiking neurons (RS), a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00807-3
更新日期：1995-10-23 00:00:00
abstract：:Sterol regulatory element binding protein (SREBP)-1 is a membrane-bound transcription factor that regulates the expression of several genes involved in cellular fatty acid synthesis in the peripheral tissues, including liver. Although SREBP-1 is expressed in brain, little is known about its function. The aim of the pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.081
更新日期：2006-04-07 00:00:00
abstract：:Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91265-2
更新日期：1980-01-06 00:00:00
abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.028
更新日期：2006-01-05 00:00:00
abstract：:A commissural-associational entorhino-entorhinal projection in the guinea pig was analyzed using anterograde and retrograde axonal tracing techniques. The projection originated in layer II and terminated in layer Ia of both the medial entorhinal area (MEA) and the lateral entorhinal area (LEA). A few cells in other la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90117-0
更新日期：1989-12-25 00:00:00
abstract：:Defined concentrations of quinolinate (QUIN) were administered to murine cortical neurons in culture impaled for intracellular recording. In physiological recording medium containing 1 mM Mg, concentrations of QUIN up to 2 mM had minimal effect on membrane potential and input resistance; only at higher concentrations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90233-2
更新日期：1987-09-08 00:00:00
abstract：:In the schedule-induced polydipsia model, hungry rats receiving a food pellet every minute will display excessive drinking behaviour (compulsive behaviour). We aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), the mediodorsal thalamic nucleus (MD) or the bed nucleus of the stria terminal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.043
更新日期：2008-03-27 00:00:00
abstract：:The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent mann...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91331-a
更新日期：1990-08-13 00:00:00
abstract：:The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91516-2
更新日期：1987-07-21 00:00:00
abstract：:In the present study we have examined the effects of changes in potassium and calcium concentration on the early adaptation of the slowly adapting stretch receptor of the crayfish using intracellular recordings including the potential clamp technique. This was because previous studies had suggested that the early adap...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90409-3
更新日期：1985-06-10 00:00:00
abstract：:Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91050-5
更新日期：1988-05-24 00:00:00
abstract：:Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities. Because of the relationship between exercise and anorexia nervosa, we explored the weight-loss syndrome produced by wheel running in food-deprived rats. Its effects on regional vasopressin and oxytocin concentrations were determined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91659-g
更新日期：1993-05-28 00:00:00
abstract：:Spinal administration of low doses of dynorphin, beta-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91069-9
更新日期：1987-01-27 00:00:00
abstract：:K+ and Cl- transport using 42K+ and 36Cl- was studied in primary astrocyte cultures prepared from neonatal rat brains. A component of 42K+ uptake was sensitive to both furosemide and bumetanide with maximum inhibition being obtained at 1 and 0.01 mM concentrations of the inhibitors, respectively. Furosemide and bumeta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91282-x
更新日期：1985-12-30 00:00:00
abstract：:The thalamic midline/intralaminar complex is part of the higher-order thalamus, which receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways. The midline thalamic nuclei connect with the medial prefrontal cortex and the medial temporal lobe. On the other hand, the intralaminar nuc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.047
更新日期：2014-10-24 00:00:00
abstract：:Oxidative stress plays an important role in the pathogenesis of neurodegeneration after the acute central nervous system injury. We reported previously that increased nitric oxide (NO) production following spinal cord hemisection tends to lead to neurodegeneration in neurons of the nucleus dorsalis (ND) that normally ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.003
更新日期：2005-09-07 00:00:00
abstract：:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90274-9
更新日期：1984-12-03 00:00:00
abstract：:By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90957-7
更新日期：1987-08-18 00:00:00
abstract：:In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91888-0
更新日期：1994-03-21 00:00:00
abstract：:Perinatal exposure to environmental tobacco smoke (ETS) has adverse effects on neurobehavioral development. In the current study, rats were exposed to ETS during gestation, during the early neonatal period, or both. Brains and hearts were examined for alterations in adenylyl cyclase (AC) activity and for changes in be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02145-x
更新日期：2001-04-13 00:00:00
abstract：:Music is an intriguing stimulus widely used in movies to increase the emotional experience. However, no brain imaging study has to date examined this enhancement effect using emotional pictures (the modality mostly used in emotion research) and musical excerpts. Therefore, we designed this functional magnetic resonanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.065
更新日期：2006-02-23 00:00:00
abstract：:The effects of two specific tyrosine kinase inhibitors on long-term potentiation (LTP) in the dentate gyrus were investigated using anesthetized rats. I.c.v. injection of herbimycin A (1.74 nmol) or lavendustin A (1.31 nmol) before application of tetanic stimulation significantly inhibited the formation of LTP. Howeve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90315-e
更新日期：1993-09-03 00:00:00
