Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus.

abstract：:In the present investigation, electron probe X-ray microanalysis was used to characterize the effects of in vitro ouabain (2 mM) or anoxia on elemental composition (e.g. Na, K, Ca) and water content of rat peripheral (tibial) nerve myelinated axons and Schwann cells. Results showed that independent of axon size, both ...

journal_title：Brain research

authors： Lehning EJ,Doshi R,Stys PK,LoPachin RM Jr

更新日期：1995-10-02 00:00:00

abstract：:Voltage-activated Na+ channels in the primary sensory neurons are important for generation of action potentials and regulation of neurotransmitter release. The Na+ channels expressed in different types of dorsal root ganglion (DRG) neurons are not fully known. In this study, we determined the possible difference in te...

journal_title：Brain research

authors： Wu ZZ,Pan HL

更新日期：2004-12-17 00:00:00

abstract：:Patients with Parkinson's disease (PD) manifest difficulty in initiation and execution of movements, particularly when movements are sequential, simultaneous or repetitive. Eye movements are particularly effective in evaluating motor impairments. We utilized a series of saccadic eye movement paradigms to explore the a...

journal_title：Brain research

authors： Winograd-Gurvich C,Georgiou-Karistianis N,Fitzgerald PB,Millist L,White OB

更新日期：2006-08-23 00:00:00

abstract：:Two rat lines bred for kindling susceptibility were previously observed to engage in different behavioral strategies in tests of emotionality. In order to extend past research on defensive behaviors in these strains which largely used males, Fast- and Slow-kindling females were assessed for anxiety-like behaviors in a...

journal_title：Brain research

authors： Runke D,McIntyre DC

更新日期：2008-11-13 00:00:00

abstract：:We examined the electrophysiological properties of cholinergic and non-cholinergic neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro slice preparation. Cells were identified electrophysiologically, filled with Lucifer yellow, fixed and processed for immunohistochemistry with fluoresc...

journal_title：Brain research

authors： Markram H,Segal M

更新日期：1990-04-09 00:00:00

abstract：:The link between the immunolocalization of apolipoproteins E (apo E) and J (apo J) and the different severity of beta-amyloid deposition in various areas of Alzheimer's disease (AD) and Down's syndrome (DS) brain was analyzed. Both apolipoproteins were found in all types of senile plaques (SPs) in the cerebral cortex,...

journal_title：Brain research

authors： Kida E,Choi-Miura NH,Wisniewski KE

更新日期：1995-07-10 00:00:00

abstract：:The rat hippocampus contains an acidic macromolecular neurotrophic factor (NTF) which supports the survival of cultured chick ciliary ganglion cells. Hippocampal NTF increases approximately 2-fold from birth to adulthood with no further change with aging. Disruption of extrinsic inputs to the hippocampus from the ento...

journal_title：Brain research

authors： Heacock AM,Schonfeld AR,Katzman R

更新日期：1986-01-22 00:00:00

abstract：:The insular cortex (IC) has been reported to modulate the cardiac parasympathetic activity of the baroreflex in unanesthetized rats. However, which neurotransmitters are involved in this modulation is still unclear. In the present study, we evaluated the possible involvement of local IC-noradrenergic neurotransmission...

journal_title：Brain research

authors： Alves FH,Crestani CC,Resstel LB,Correa FM

更新日期：2009-10-27 00:00:00

abstract：:Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...

journal_title：Brain research

authors： Ponce-Lopez T,Liy-Salmeron G,Hong E,Meneses A

更新日期：2011-12-02 00:00:00

abstract：:The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...

journal_title：Brain research

authors： Abudara V,Jiang RG,Eyzaguirre C

更新日期：2001-10-19 00:00:00

abstract：:Several human tumour cell lines were screened for secretion of proenkephalin-derived peptides with an antiserum directed to its N-terminus, Met-enkephalin-Arg6,Phe7 and for proopiomelanocortin-derived peptides with an antiserum to beta-endorphin. The neuroblastoma SK-N-MC cell line secreted Met-enkephalin-Arg6,Phe7-im...

journal_title：Brain research

authors： Folkesson R,Monstein HJ,Geijer T,Påhlman S,Nilsson K,Terenius L

更新日期：1988-04-01 00:00:00

abstract：:Fractionated partial or whole-brain irradiation (fWBI) is a widely used, effective treatment for primary and metastatic brain tumors, but it also produces radiation-induced brain injury, including cognitive impairment. Radiation-induced neural changes are particularly problematic for elderly brain tumor survivors who ...

journal_title：Brain research

authors： Shi L,Olson J,D'Agostino R Jr,Linville C,Nicolle MM,Robbins ME,Wheeler KT,Brunso-Bechtold JK

更新日期：2011-04-18 00:00:00

abstract：:The morphological and physiological identification of the cells in the inner retina of Japanese dace was made by means of intracellular single cell recording and dye injection techniques. Our flat mounts and physiological classification revealed that 97 out of 102 sample cells were amacrine cells except for 3 transien...

journal_title：Brain research

authors： Chino YM,Hashimoto Y

更新日期：1986-05-07 00:00:00

abstract：:Despite the significant advances that have been made in understanding the pathophysiology of cerebral ischemia on the cellular and molecular level, only one drug, the thrombolytic tissue plasminogen activator (rt-PA), is approved by the FDA for use in patients with acute ischemic stroke. Therefore, there is a critical...

journal_title：Brain research

authors： Maher P,Salgado KF,Zivin JA,Lapchak PA

更新日期：2007-10-10 00:00:00

abstract：:The ability of heterotopic noxious stimuli to inhibit the activity of dorsal horn convergent neurones was investigated in both intact anesthetized, and spinal unanesthetized rats. Forty-four convergent neurones in lumbar dorsal horn were recognized by their ability to respond to both noxious and non-noxious natural st...

journal_title：Brain research

authors： Cadden SW,Villanueva L,Chitour D,Le Bars D

更新日期：1983-09-19 00:00:00

abstract：:Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...

journal_title：Brain research

authors： Pomeranz B,Bibic L

更新日期：1988-06-14 00:00:00

abstract：:Application of horseradish peroxidase (HRP) to the proximal stump of the transected infraorbital (IO) nerve in the orbit was employed in normal adult rats to demonstrate the ganglionic representation of and brainstem innervation by the trigeminal (V) branch which supplies primarily the mystacial vibrissae. In the V ga...

journal_title：Brain research

authors： Jacquin MF,Rhoades RW

更新日期：1983-06-13 00:00:00

abstract：:The localization of human hand primary motor area (M1) has been the object of several studies during the last decades. EEG source analysis, functional magnetic resonance imaging (fMRI) and focal transcranial magnetic stimulation (TMS) are non-invasive methods for localizing M1 with good accuracy compared to direct ele...

journal_title：Brain research

authors： Inuggi A,Filippi M,Chieffo R,Agosta F,Rocca MA,González-Rosa JJ,Cursi M,Comi G,Leocani L

更新日期：2010-01-13 00:00:00

abstract：:(1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a com...

journal_title：Brain research

authors： Homma S

更新日期：1979-09-14 00:00:00

abstract：:The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h afte...

journal_title：Brain research

authors： Itagaki S,Kimura H

更新日期：1986-08-27 00:00:00

abstract：:Rabbits reared from birth in stroboscopic illumination have no experience of visual motion. In primary visual cortex of these animals there is a large reduction in the number of cells which are direction selective. This result, contrary to previous reports, shows that the rabbit visual system can be modified by early ...

journal_title：Brain research

authors： Pearson HE,Berman N,Murphy EH

更新日期：1981-01-01 00:00:00

abstract：:The aim of the present study was to evaluate p38 MAPK activation following focal stroke and determine whether SB 239063, a novel second generation p38 inhibitor, would directly attenuate early neuronal injury. Following permanent middle cerebral artery occlusion (MCAO), brains were dissected into ischemic and non-isch...

journal_title：Brain research

authors： Legos JJ,Erhardt JA,White RF,Lenhard SC,Chandra S,Parsons AA,Tuma RF,Barone FC

更新日期：2001-02-16 00:00:00

abstract：:We have recently characterized the histopathological changes in an experimental model of mesial temporal lobe epilepsy (MTLE) induced by the intrahippocampal injection of low dose of kainate in mice. Although cerebral metabolism and blood flow are extensively studied and used in human MTLE to locate the regions involv...

journal_title：Brain research

authors： Bouilleret V,Boyet S,Marescaux C,Nehlig A

更新日期：2000-01-10 00:00:00

abstract：:Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...

journal_title：Brain research

authors： Zhang Y,Wang M,Li H,Zhang H,Shi Y,Wei F,Liu D,Liu K,Chen D

更新日期：2012-06-06 00:00:00

abstract：:The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 microliters/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid ...

journal_title：Brain research

authors： Yoshioka M,Matsumoto M,Togashi H,Smith CB,Saito H

更新日期：1993-06-04 00:00:00

abstract：:Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...

journal_title：Brain research

authors： Zhang Y,Xiong Y,Mahmood A,Meng Y,Qu C,Schallert T,Chopp M

更新日期：2009-10-19 00:00:00

abstract：:Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...

journal_title：Brain research

authors： Spaniol J,Bowen HJ,Wegier P,Grady C

更新日期：2015-07-01 00:00:00

abstract：:When female golden hamsters are maintained on a photoperiod of less than 12.5 h of light per day, they go into a pineal gland-induced anestrus in 6-10 weeks. This acyclicity is similar in certain respects to the testicular regression which occurs in male golden hamsters maintained on a short photoperiod. A recent stud...

journal_title：Brain research

authors： Pieper DR,Samyn MM,Heverly RN

更新日期：1986-08-13 00:00:00

abstract：:The locus coeruleus of the adult albino rat is a clearly delimited nucleus in Nissl-stained preparations. It is surrounded by an extensive, relatively neuron-free neuropil which is not stained in reduced silver and Luxol fast blue preparations. Most if not all locus coeruleus neurons contain the enzyme dopamine-beta-h...

journal_title：Brain research

authors： Swanson LW

更新日期：1976-06-25 00:00:00

abstract：:After an intraventricular administration of colchicine, the arcuate nucleus of rat hypothalamus was examined light and electron microscopically by pre-embedding immunohistochemistry for somatostatin. The arcuate nucleus exhibited numerous immunoreactive cell bodies and dense networks of immunoreactive fibers. The fibe...

journal_title：Brain research

authors： Ohtsuka M,Hisano S,Daikoku S

更新日期：1983-03-21 00:00:00