Spinal antinociceptive action of three representative opioid peptides in frogs.

Abstract:

:Spinal administration of low doses of dynorphin, beta-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antinociception in this amphibian species. Of particular interest, spinally administered dynorphin produces a potent antinociception in frogs without any signs of motor dysfunction seen after spinally administered dynorphin in mammalian species.

journal_name

Brain Res

journal_title

Brain research

authors

Stevens CW,Pezalla PD,Yaksh TL

doi

10.1016/0006-8993(87)91069-9

subject

Has Abstract

pub_date

1987-01-27 00:00:00

pages

201-3

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)91069-9

journal_volume

402

pub_type

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