Abstract:
:Spinal administration of low doses of dynorphin, beta-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antinociception in this amphibian species. Of particular interest, spinally administered dynorphin produces a potent antinociception in frogs without any signs of motor dysfunction seen after spinally administered dynorphin in mammalian species.
journal_name
Brain Resjournal_title
Brain researchauthors
Stevens CW,Pezalla PD,Yaksh TLdoi
10.1016/0006-8993(87)91069-9subject
Has Abstractpub_date
1987-01-27 00:00:00pages
201-3issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)91069-9journal_volume
402pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90539-x
更新日期:1982-05-13 00:00:00
abstract::An increasing number of studies suggest that learning to read changes the way the brain processes spoken language. Yet, there is still a hot debate about the locus of these literacy effects. While most psycholinguists would argue that these effects are late and postlexical, interactive theories of word recognition sug...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.084
更新日期:2008-01-10 00:00:00
abstract::Buffy coat of three members from a family with Alzheimer's disease was inoculated into hamster brains. Eighteen months after the inoculation, all experimental animals were sacrificed for the neuropathological study. Hematoxylin-eosin staining showed no gross vacuolar degeneration, or neuronal loss in the cortex. The s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90949-v
更新日期:1991-06-14 00:00:00
abstract::The postnatal development of the distribution of 3 different ionic channel proteins in rat brain was studied using light microscopic autoradiography. [3H]Ethylenediaminetetrodotoxin, [125I]apamin and (-)-[3H]desmethoxyverapamil were used to label one class of voltage-dependent Na+ channel proteins, one class of Ca2+-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90175-2
更新日期:1987-08-04 00:00:00
abstract::The spatio-temporal characteristics of release of acetylcholinesterase from the in vivo substantia nigra can now be described using a chemiluminescent reaction. Electrical stimulation of the striatum caused an increase in release of acetylcholinesterase within the ipsilateral substantia nigra; however, this increase i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90128-5
更新日期:1989-12-25 00:00:00
abstract::The properties of inward-rectifying membrane currents in immature rat olfactory cortex neurones (postnatal day (P) 10-22) were analysed using whole-cell patch-clamp recordings. In 78% of cells (40/51), injection of hyperpolarizing current pulses elicited graded electrotonic potentials showing a slowly developing sag i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01067-1
更新日期:1998-12-14 00:00:00
abstract::The patch clamp technique has been used to study ion channel activity in the apical (ventricular) membrane of epithelial cells from the rat choroid plexus. Two different classes of Cl(-)-selective channel were identified. A low conductance (26 pS) channel which was the predominant feature in cell-attached and inside-o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90988-l
更新日期:1992-09-18 00:00:00
abstract::We have shown earlier that nicotinic agonists induce the release of noradrenaline from chick sympathetic neurons in culture in two ways: (a) by activating the postsynaptic nicotinic receptors on nerve cell bodies, giving rise to spreading electrical activity and opening of voltage operated calcium channels in neuronal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00876-1
更新日期:1996-11-18 00:00:00
abstract::NO (nitric oxide) produced in limbic brain regions has important roles in the regulation of autonomic nervous system and HPA axis activity, anxiety, fear learning, long-term memory formation, and depression. NO is synthesized from l-arginine in a reaction catalyzed by nitric oxide synthase (NOS). Neuronal nitric oxide...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.090
更新日期:2011-01-12 00:00:00
abstract::The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01466-3
更新日期:1999-06-19 00:00:00
abstract::Two rat lines bred for kindling susceptibility were previously observed to engage in different behavioral strategies in tests of emotionality. In order to extend past research on defensive behaviors in these strains which largely used males, Fast- and Slow-kindling females were assessed for anxiety-like behaviors in a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.08.090
更新日期:2008-11-13 00:00:00
abstract::Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean +/- S.D. = 1,234 +/- 543 microm(2)). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related pep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.092
更新日期:2006-04-12 00:00:00
abstract::Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02263-1
更新日期:2002-03-22 00:00:00
abstract::Previous reports from this laboratory have indicated that fetal rat striatal grafts have the major types of neuronal and glial components known to be involved in Huntington's chorea. In this study a number of major afferent and efferent innervations seen in normal striatum were examined in the striatal grafts and were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91592-8
更新日期:1989-12-11 00:00:00
abstract::Prenatal cocaine exposure causes alterations in auditory brainstem response in children and experimental animals and has adverse effects on auditory information processing and language skills in children. These effects may result from lesions in the cochlea since this organ is particularly sensitive to chemical insult...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.066
更新日期:2006-05-01 00:00:00
abstract::It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be related to its effects on the anti-oxidant defence systems. However, undernutrition during the gestation and pre-weaning period is known to have long-term deleterious effects on a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.046
更新日期:2008-07-30 00:00:00
abstract::Cultured cells derived from Tay-Sachs disease (TSD) fetal cerebellum were shown to accumulate GM2 ganglioside when compared with control cultures. In contrast, fibroblasts derived from TSD fetal lung do not contain GM2. GM2 was identified by thin-layer chromatography (TLC) and confirmed by gas-liquid chromatography (G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)91052-0
更新日期:1976-07-23 00:00:00
abstract::The localization of human hand primary motor area (M1) has been the object of several studies during the last decades. EEG source analysis, functional magnetic resonance imaging (fMRI) and focal transcranial magnetic stimulation (TMS) are non-invasive methods for localizing M1 with good accuracy compared to direct ele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.042
更新日期:2010-01-13 00:00:00
abstract::The effects of chronic administration of naloxone, morphine and met-enkephalin on benzodiazepine (BDZ) receptor binding in rat brain were determined 2 and 50 days after treatments were accomplished. Two days after naloxone treatment (75 micrograms/h s.c. for 14 days), enhanced BDZ receptor binding was observed in cing...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91668-i
更新日期:1993-05-28 00:00:00
abstract::The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertiliz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03065-1
更新日期:2001-01-12 00:00:00
abstract::The purposes of this study were to examine responses of superficial (depth <300 microm) and deeper thoracic spinal neurons to chemical stimulation of cardiac afferents and effects of descending influences on these neurons. Extracellular potentials of single T(3)-T(4) neurons were recorded in pentobarbital anesthetized...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03728-9
更新日期:2003-01-03 00:00:00
abstract::Using psychophysical techniques, the ability of human subjects to discriminate the velocity of brush movement across the glabrous skin of the hand was determined. The same stimulus was then used in a series of neurophysiological experiments designed to determine the ability of neurons in the primary somatosensory cort...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90746-5
更新日期:1980-10-06 00:00:00
abstract::The neuroprotection research in the last 2 decades has witnessed a growing interest in the functions of estrogens as neuroprotectants against neurodegenerative diseases including stroke. The neuroprotective action of estrogens has been well demonstrated in both in vitro and in vivo models of ischemic stroke. However, ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2013.01.023
更新日期:2013-06-13 00:00:00
abstract::In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01310-9
更新日期:1999-02-20 00:00:00
abstract::The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02300-9
更新日期:2001-05-18 00:00:00
abstract::Full limbic seizures were kindled in rats by repeated, bi-daily microinjections of glutamate (1.5 mumol) into the basolateral amygdala. Co-administration of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid with the glutamate, prevented the development of both electroencephalographi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91279-p
更新日期:1990-01-08 00:00:00
abstract::The distinction between neural mechanisms of explicit and implicit expressions of memory has been well studied at the retrieval stage, but less at encoding. In addition, dissociations obtained in many studies are complicated by methodological difficulties in obtaining process-pure measures of different types of memory...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.08.024
更新日期:2014-10-17 00:00:00
abstract::Lesions to the ventromedial hypothalamus (VMH) inhibit receptive sexual behavior in the whiptail lizard, Cnemidophorus uniparens, an all-female species. All lesions to the VMH that effectively abolished receptivity specifically damaged the dorsal lateral VMH, an area containing high concentrations of estrogen receptor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00191-r
更新日期:1995-05-22 00:00:00
abstract::Adult Wistar rats injected with the dopamine receptor agonist apomorphine display different types of motility patterns with respect to oral stereotypes and locomotor activities. It was tested whether phenotypes exhibiting either 'sniffing' or 'non-sniffing' behaviour differed in gene structures of dopamine receptors D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03136-5
更新日期:2002-02-01 00:00:00
abstract::The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.016
更新日期:2010-01-15 00:00:00