Abstract：
:Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo). Intravenous NAm given 2 h after MCAo significantly reduced the infarct volume of SHR (750 mg/kg, 31%, P<0.01) and diabetic (500 mg/kg, 56%, P<0.01) as well as non-diabetic (500 mg/kg, 73%, P<0.01) Fischer 344 rats when compared with saline-injected controls. Thus delayed treatment with NAm protected hypertensive and hyperglycemic rats against a robust model of stroke.
journal_name
Brain Resjournal_title
Brain researchauthors
Sakakibara Y,Mitha AP,Ayoub IA,Ogilvy CS,Maynard KIdoi
10.1016/s0006-8993(02)02263-1subject
Has Abstractpub_date
2002-03-22 00:00:00pages
68-73issue
1eissn
0006-8993issn
1872-6240pii
S0006899302022631journal_volume
931pub_type
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