Abstract：
:The blood-brain interface in elasmobranchs was examined using physiological and anatomical techniques. Electrolyte analyses of plasma and cerebrospinal fluid (CSF) in control fish and in fish with elevated plasma cation concentration (Ca, Mg or K) demonstrated homeostasis of CSF calcium and magnesium concentrations in dogfish and skates and of CSF potassium concentration in dogfish. In contrast, CSF potassium concentration was not regulated independent of plasma potassium concentration in skates. Ultrastructural examination of the blood-brain barrier in skates showed that brain capillaries are fenestrated and intravenously injected horseradish peroxidase penetrates readily across this endothelium into the basement membrane. Further penetration of tracer into the neuropil is prevented by tight junctions between perivascular glial cells. Results indicate that two hallmarks of the blood-brain barrier--impermeability and homeostatic transport systems--can be localized to the perivascular glial sheath in elasmobranchs. The functional and structural similarity of this glial membrane to a transporting epithelium is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Bundgaard M,Cserr Hdoi
10.1016/0006-8993(81)91083-0subject
Has Abstractpub_date
1981-12-07 00:00:00pages
61-73issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(81)91083-0journal_volume
226pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The levels of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG) were measured in several regions and in whole brain of rats from 15 days of gestation (DG) to adulthood by means of an isocratic HPLC method. The levels of NAAG in whole brain increased 3-fold between 15 DG and birth, which was 90% of the ad...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90150-0
更新日期：1984-07-01 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) and the pineal body in 3 types of inherited hormone-deficient mice, the dw, lit and hyt mice were examined by morphological, morphometric and biochemical techniques. In the dw and lit mice the SCN was underdeveloped. In the ventral part of the SCN, where most of the retinal fibers app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90279-8
更新日期：1986-05-01 00:00:00
abstract：:The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147237
更新日期：2021-01-02 00:00:00
abstract：:Nerve growth activities in rat sciatic nerves were assayed by recording the neuritic outgrowth from chick embryonic ganglia cultured in collagen gels beside nerve fragments for two days. Living nerve explants released activity that resembled nerve growth factor (NGF) in its effect on sympathetic ganglia and that was a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90141-x
更新日期：1982-08-19 00:00:00
abstract：:Individual choroid plexuses of human fetal brain at different developmental stages were investigated by an indirect immunoperoxidase technique. The number and distribution of prealbumin-, albumin-, alpha-fetoprotein-, transferrin-, IgG-, IgA-, IgM- and alpha 1-antitrypsin-containing choroid plexus epithelial cells wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90025-6
更新日期：1982-02-01 00:00:00
abstract：:In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy fr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90819-x
更新日期：1986-04-16 00:00:00
abstract：:Phenylethanolamine N-methyltransferase (PNMT) activity was measured in adrenal glands and medulla oblongata from 4 inbred rat strains, Fischer 344, Buffalo, Lewis and Sprague-Dawley rats. Adrenal enzyme activity was markedly different among the strains with the highest in Fischer, followed by Sprague-Dawley, Lewis and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91476-9
更新日期：1986-04-30 00:00:00
abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00539-8
更新日期：1997-08-29 00:00:00
abstract：:Coated vesicles within dentate gyrus granule cell dendrites were found free in the cytoplasm and also attached to the smooth endoplasmic reticulum and plasmalemma. Coated vesicles began increasing in number 40-48 h following partial dendritic deafferentation. This increase continued up to 15-30 days postlesion, after ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90076-7
更新日期：1981-04-27 00:00:00
abstract：:Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91028-x
更新日期：1984-08-20 00:00:00
abstract：:The effects of propylthiouracil (PTU)-induced thyroid deficiency on [14C]acetylcholine synthesis and 14CO2 production from [U-14C]glucose in vitro, by fine prisms of the corpus striatum were investigated in developing rats. Consistent with deficits in choline uptake and choline acetyltransferase activity (Kalaria et a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90114-2
更新日期：1985-06-01 00:00:00
abstract：:Nineteen convergent neurones, 19 'non-noxious only' neurones and 13 'proprioceptive' neurones all with peripheral excitatory receptive fields on the ipsilateral hindpaw, were recorded in the lumbar dorsal horn of non-spinalized, anaesthetized rats. These neurones were all excited by the electrophoretic application of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91147-8
更新日期：1984-04-23 00:00:00
abstract：:Cerebellar granule neuronal cultures have been used to study the molecular mechanisms underlying neuronal functions, including neuronal morphogenesis. However, a limitation of this system is the difficulty to analyze isolated neurons because these are required to be maintained at a high density. Therefore, in the pres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.046
更新日期：2013-11-20 00:00:00
abstract：:Maternal melatonin readily crosses the placenta to provide the fetus with time-of-day and day length information. To determine if melatonin could have a broader role during development than is currently recognized, melatonin receptor expression was examined in somatic sites during Siberian hamster embryogenesis. Using...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91424-y
更新日期：1991-12-24 00:00:00
abstract：:Visual pathways (optic disc, optic nerve and pretectal regions) were electrically stimulated and evoked potentials were explored throughout the inferior olive in the anesthetized rat. Responsive areas were identified as the caudal half of the dorsal cap, nucleus beta and the most caudal region of subnucleus c of the m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91060-7
更新日期：1986-03-12 00:00:00
abstract：:The effects of postnatal thyroidectomy (on day 8 after birth) and 131I treatment (on day 10) on the development of the vomeronasal organ (VO) has been studied In the rat. Thyroidectomized rats showed decrements in the overall VO volume, volume of the neurosensorial epithelium, neuronal population and nuclear size of n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90159-6
更新日期：1982-10-01 00:00:00
abstract：:Quantitative [125I]protein G-based immunohistochemistry was used to map the distribution of beta1 thyroid hormone receptor (TRbeta1) in normal and thyroidectomized adult rat brain, using a previously characterized polyclonal antibody. The distribution of TRbeta1-like immunoreactivity in normal brain was largely but no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00450-2
更新日期：1997-06-27 00:00:00
abstract：:Tetanization of commissural-CA1 input to the apical dendrites of the dorsal hippocampal CA1 area was found to produce a marked long-term potentiation of the field EPSP. Whereas by concurrent tetanization of the commissural pathway and medial septo-CA1 input, this potentiation was significantly reduced. Thus a negative...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91201-2
更新日期：1988-04-05 00:00:00
abstract：:An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic device for measuring in humans the same kinds of rotational movements observed in rats. Our data indicate that, without being ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91074-2
更新日期：1987-05-19 00:00:00
abstract：:To determine the respiratory effects of inhibiting carbonic anhydrase in brain tissue, we infused acetazolamide (ACZ) into the cisterna magna in anesthetized rats. Three concentrations, 4.5, 45 and 450 microM in artificial cerebrospinal fluid, were infused continuously at 2 microliter/min for 20 min and the responses ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90056-h
更新日期：1990-06-11 00:00:00
abstract：:We have previously used organotypic cultures to study mechanisms regulating phenotypic expression of neurotransmitter characters in the brain. Our previous work indicated that nerve growth factor (NGF) specifically increased the activity of choline acetyltransferase (CAT) in striatal cholinergic interneurons. In the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91136-x
更新日期：1987-06-02 00:00:00
abstract：:The contribution of glutamatergic transmission to generation of initial convulsive seizures (CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), affects the onset and progression of initial CS by cholinergic stimulus in juvenile rats. Male rats (24 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147253
更新日期：2021-02-15 00:00:00
abstract：:Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. Neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreact...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02925-5
更新日期：2000-12-08 00:00:00
abstract：:The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90974-7
更新日期：1987-08-18 00:00:00
abstract：:Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is believed to have a key role in a default network and be involved in the pathophysiology of AD, few studies have investigated whole-brain functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.028
更新日期：2009-12-11 00:00:00
abstract：:Transient global cerebral ischemia has been shown to induce marked changes in the polyamine pathway with a significant increase in putrescine, the product of the ornithine decarboxylase reaction. This study examined the relationship between tissue and extracellular polyamines and regional cerebral blood flow and brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(96)01116-X
更新日期：1997-01-09 00:00:00
abstract：:A procedure has been developed for the stable long-term recording of nerve signals in unanesthetized mammals, which should have wide application in basic research on the nervous system and also in clinical areas such as the derivation of control signals for powered prostheses. Methods are fully described for construct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90233-5
更新日期：1977-06-03 00:00:00
abstract：:Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00874-p
更新日期：1995-11-06 00:00:00
abstract：:The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.019
更新日期：2013-06-23 00:00:00
abstract：:In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91358-3
更新日期：1988-01-12 00:00:00
