Effects of biogenic aldehydes and aldehyde dehydrogenase inhibitors on rat brain tryptophan hydroxylase activity in vitro.

abstract：:A number of studies describe strain-related differences in the motor behavior of rats. Inbred albino F344 rats are found to be impaired in procedural spatial learning, skilled reaching, and over ground locomotion in relation to pigmented out bred Long Evans (LE) rats. These deficits could be related to the functional ...

journal_title：Brain research

authors： Wawryko P,Ward NL,Whishaw IQ,Ivanco TL

更新日期：2004-12-10 00:00:00

abstract：:We have recently reported spinal blood flow-metabolism uncoupling in an amyotrophic lateral sclerosis (ALS) animal model using Cu/Zn-superoxide dismutase 1 (SOD1)-transgenic (Tg) mice, suggesting a relative hypoxia in the spinal cord. However, the hypoxic stress sensor pathway has not been well studied in ALS. Here, w...

journal_title：Brain research

authors： Sato K,Morimoto N,Kurata T,Mimoto T,Miyazaki K,Ikeda Y,Abe K

更新日期：2012-09-14 00:00:00

abstract：:Tactile stimulation of the body surface elicited climbing fiber responses in 5% of the 839 Purkinje cells recorded in the caudal posterior vermis (lobules VII-IX) of cats anesthetized with sodium pentobarbital. The cells responsive to tactile stimulation were mainly encountered around the prepyramidal fissure between ...

journal_title：Brain research

authors： Brons J,Robertson LT,Tong G

更新日期：1990-06-11 00:00:00

abstract：:Glutamate stimulation of the lateral supramammillary nucleus (SUL) in urethane anaesthetized rats produced a substantial increase in the amplitude of the perforant path-evoked population spike in the dentate gyrus, without affecting the population EPSP slope. One third of the spike enhancements lasted longer than 20 m...

journal_title：Brain research

authors： Carre GP,Harley CW

更新日期：1991-12-24 00:00:00

abstract：:In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...

journal_title：Brain research

authors： Britt RH

更新日期：1976-08-13 00:00:00

abstract：:(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques. (2) Lesions of the midlateral hypothal...

journal_title：Brain research

authors： Kucharczyk J,Assaf SY,Mogenson GJ

更新日期：1976-05-28 00:00:00

abstract：:The so-called on- and off-cells of the rostral ventromedial medulla (RVM) send their axons to the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and activation of off-cells coincides with an inhibition, of withdrawal reflexes elicited by noxious agents. Considerable evidence sup...

journal_title：Brain research

authors： Salas R,Ramirez K,Tortorici V,Vanegas H,Vazquez E

更新日期：2018-05-01 00:00:00

abstract：:Nociceptin/orphanin FQ is an endogenous neuropeptide that plays important roles in several physiological functions including pain, anxiety, locomotion, learning, and memory. We previously reported that low doses of nociceptin improved the scopolamine-induced impairment of learning and memory in the passive avoidance t...

journal_title：Brain research

authors： Hiramatsu M,Miwa M,Hashimoto K,Kawai S,Nomura N

更新日期：2008-02-21 00:00:00

abstract：:This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...

journal_title：Brain research

authors： Tsitolovsky LE,Babkina NV

更新日期：1992-11-06 00:00:00

abstract：:This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...

journal_title：Brain research

authors： Foster TC,Fugger HN,Cunningham SG

更新日期：2000-07-14 00:00:00

abstract：:While it is generally assumed that cocaine self-administration (SA) is determined and maintained by the pharmacological actions of cocaine in the brain, it is also a drug-motivated and drug-reinforced goal-directed behavior, which is determined by concurrent learning and behavioral performance. To dissociate the contr...

journal_title：Brain research

authors： Kiyatkin EA,Brown PL

更新日期：2004-04-16 00:00:00

abstract：:Although it has been reported that dendritic neurotransmitter releases from amacrine cells are regulated by the intracellular Ca(2+) concentration ([Ca(2+)](i)), their spatiotemporal patterns are not well explained. Fast Ca(2+) imagings of amacrine cells in the horizontal slice preparation of goldfish retinas under wh...

journal_title：Brain research

authors： Azuma T,Enoki R,Iwamuro K,Kaneko A,Koizumi A

更新日期：2004-10-08 00:00:00

abstract：:The locus coeruleus of the adult albino rat is a clearly delimited nucleus in Nissl-stained preparations. It is surrounded by an extensive, relatively neuron-free neuropil which is not stained in reduced silver and Luxol fast blue preparations. Most if not all locus coeruleus neurons contain the enzyme dopamine-beta-h...

journal_title：Brain research

authors： Swanson LW

更新日期：1976-06-25 00:00:00

abstract：:Although it is generally believed that the central projections of the retina in birds are entirely crossed, using wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) as an anterograde tracer, we have found that in normal posthatched chicks there is a small ipsilateral retinofugal projection to the dience...

journal_title：Brain research

authors： O'Leary DM,Gerfen CR,Cowan WM

更新日期：1983-10-01 00:00:00

abstract：:To evaluate a hypothesized role of the vagus in the circannual metabolic cycle of hibernators, measures of annual weight gain, weight loss and cycle period were taken for the ground squirrel, Citellus lateralis, maintained in constant environmental conditions before and after subdiaphragmatic vagotomy. The surgery did...

journal_title：Brain research

authors： Powley TL,Fox EA

更新日期：1986-01-29 00:00:00

abstract：:Early microglial reaction following mild ischemic injury caused by bilateral common carotid artery occlusion has been investigated in rats. The ischemic insults lasted for 10, 15 and 20 min without recirculation, and with several reperfusion intervals from 1 h to 3 days. The resting and activated microglial cells were...

journal_title：Brain research

authors： Abrahám H,Lázár G

更新日期：2000-04-17 00:00:00

abstract：:Experiments were carried out in rats to (1) elaborate upon the sepcificity of drug action in the periaqueductal gray matter (PAG), and (2) to evaluate the posible congruence of PAG sites of morphine-induced and stimulation-produced analgesis (SPA) applied at virtually identical PAG loci. It was demonstrated that the e...

journal_title：Brain research

authors： Lewis VA,Gebhart GF

更新日期：1977-03-25 00:00:00

abstract：:Opioids elicit antinociception in mammals through three distinct types of receptors designated as mu, kappa and delta. However, it is not clear what type of opioid receptor mediates antinociception in non-mammalian vertebrates. Radioligand binding techniques were employed to characterize the site(s) of opioid action i...

journal_title：Brain research

authors： Newman LC,Wallace DR,Stevens CW

更新日期：2000-11-24 00:00:00

abstract：:A single informon reproduces classical conditioning to compound stimuli under a wide range of conditions during reinforcement and non-reinforcement; it also reproduces simple operant conditioning. A network of 210 informons with 8400 simultaneouslly varying pathways has been simulated; it can learn to recognize handpr...

journal_title：Brain research

authors： Uttley AM

更新日期：1976-01-30 00:00:00

abstract：:In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...

journal_title：Brain research

authors： Riedel A,Klekamp J,Harper C,Kretschmann HJ

更新日期：1989-10-16 00:00:00

abstract：:The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known. In addition, S100B's ability to modulate the activity of other glial activating agents has not been defi...

journal_title：Brain research

authors： Petrova TV,Hu J,Van Eldik LJ

更新日期：2000-01-17 00:00:00

abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...

journal_title：Brain research

authors： Shirasaka T,Kunitake T,Tsuneyoshi I

更新日期：2009-12-01 00:00:00

abstract：:Microinjection of cholinergic agonists into the pontine tegmentum was used to evoke a state which was polygraphically and behaviorally similar to desynchronized (D) sleep. This study was designed to test the hypothesis that the production of this pharmacologically induced D sleep-like state (D-ACh) was dependent upon ...

journal_title：Brain research

authors： Baghdoyan HA,Rodrigo-Angulo ML,McCarley RW,Hobson JA

更新日期：1987-06-30 00:00:00

abstract：:Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...

journal_title：Brain research

authors： Bregman BS,Goldberger ME

更新日期：1983-08-01 00:00:00

abstract：:The neurotrophic effect of bFGF on dopamine (DA) neurons in vitro depends upon its mitogenic activity on glial cells. We examined whether glial secretion of the dopaminergic growth factor GDNF is responsible for the trophic activity of bFGF on mesencephalic DA neurons. When added with lower concentrations of bFGF, GDN...

journal_title：Brain research

authors： Hou JG,Mytilineou C

更新日期：1996-06-10 00:00:00

abstract：:The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...

journal_title：Brain research

authors： Drewes LR,Leino RL

更新日期：1985-08-12 00:00:00

abstract：:While adult mice receiving picrotoxin (PTX) alone responded with clonic and tonic-clonic seizures, this response was greatly suppressed for mice simultaneously injected with 2,3-butanedione monoxime (BDM). For example, 60% and 10% of the mice convulsed when injected (i.p.) with 3.0 mg/kg PTX alone or PTX plus 205 mg/k...

journal_title：Brain research

authors： Brightman T,Ye JH,Ortiz-Jimenez E,Flynn EJ,Wu WH,McArdle JJ

更新日期：1995-04-24 00:00:00

abstract：:Serotonin 1A (5HT1A) receptor agonists have shown neuroprotective properties in different models of central nervous system injury. Activation of neuronal 5HT1A receptors appears to be involved in the neuroprotective effects. It remains to be elucidated if astroglial cells are responsive to the 5HT1A neuroprotective ef...

journal_title：Brain research

authors： Ramos AJ,Rubio MD,Defagot C,Hischberg L,Villar MJ,Brusco A

更新日期：2004-12-31 00:00:00

abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...

journal_title：Brain research

authors： Altobelli GG,Cimini V

更新日期：2007-02-09 00:00:00

abstract：:Type 1 cannabinoid (CB1) receptors are expressed in high concentrations in the central nervous system, including the basal ganglia, and could have direct or indirect effects on motor behavior through modulation of dopaminergic, glutamatergic and GABA-ergic neurotransmission. Using the CB1 receptor radioligand [(18)F]M...

journal_title：Brain research

authors： Casteels C,Lauwers E,Baitar A,Bormans G,Baekelandt V,Van Laere K

更新日期：2010-02-26 00:00:00