Abstract：
:This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-dependent behavior and increased locomotor activity. Perforant path synaptic strength, measured in the in vitro hippocampal slice, was increased and long-term potentiation (LTP) was decreased for EC+SAL animals. The experience-dependent effects on synaptic function were inhibited by drug treatment. Measures of synaptic strength were correlated with hippocampal-dependent behavior and synaptic plasticity for EC animals. The results suggest a relationship between hippocampal-dependent behavior and experience-dependent modification of perforant path synaptic function through NMDAR activation.
journal_name
Brain Resjournal_title
Brain researchauthors
Foster TC,Fugger HN,Cunningham SGdoi
10.1016/s0006-8993(00)02379-9subject
Has Abstractpub_date
2000-07-14 00:00:00pages
39-43issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02379-9journal_volume
871pub_type
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