Abstract：
:Recent immunohistochemical studies have suggested that the forebrain distribution of stigmoid bodies, marked by an antibody against placental aromatase-associated antigen X-P2 (PAX), overlaps with that of the common binding sites of androgen and estrogen. In the present light- and electron-microscopy study the coexistence of stigmoid bodies and estrogen receptors (EsR) is immunohistochemically examined and quantitatively analyzed in the medial preoptic region, part of the bed nucleus of the stria terminalis and part of the medial amygdaloid nucleus of young female rats. Light microscopy with double immunostaining for PAX and EsR in all three regions indicates that 75-84% of the total of PAX-immunoreactive stigmoid structures are present in neurons which also contain EsR-immunoreactive nuclei, and that 75-78% of EsR-immunoreactive neurons contain PAX-immunoreactive inclusions. Electron microscopic analysis confirms that 70-80% of stigmoid body-containing neurons have EsR-immunoreactive nuclei. These results indicate that the majority of the stigmoid bodies and EsRs intimately coexist, strongly suggesting a functional interrelationship in brain regions which are involved in rat reproductive functions. Stigmoid bodies may play a role in subneuronal EsR mechanisms associated with aromatization in these sex steroid targets in rat brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Nagano M,Shinoda Kdoi
10.1016/0006-8993(94)91933-xsubject
Has Abstractpub_date
1994-01-21 00:00:00pages
296-304issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91933-Xjournal_volume
634pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter. Mutations in parkin are the most common cause of early-onset autosomal recessive Parkinson's disease, however the function of PACRG an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.050
更新日期：2008-03-27 00:00:00
abstract：:Several lines of evidence indicate that psychostimulant withdrawal can induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dysfunction of the serotonin (5-HT) system, including alterations in 5-HT receptors. For example, changes in 5-HT(2A) receptor function in prefrontal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.033
更新日期：2011-05-16 00:00:00
abstract：:Brief applications of high glycine concentrations to hippocampal slices have been shown to produce long-lasting changes in synaptic efficacy. In the present study, we show that glycine application transiently and reversibly increases the amplitude and prolongs the duration of synaptic potentials mediated by N-methyl-D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90329-l
更新日期：1993-11-12 00:00:00
abstract：:Binding activities specific for each of [3H]prostaglandin (PG) D2, E2 and F2 alpha were detected in the P2 fraction of the human brain homogenates. The bindings were time-dependent, saturable and of high affinity; Kd values were 30 nM for all the PG bindings. Regional distribution of these binding activities was deter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91358-7
更新日期：1985-09-02 00:00:00
abstract：:An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90300-1
更新日期：1983-07-25 00:00:00
abstract：:The cellular and subcellular localization of aspartate in the guinea pig inner ear was studied by means of quantitative postembedding cytochemistry. High levels of aspartate immunoreactivity were found in neuronal compartments, including all types of hair cells, and afferent and efferent nerve fibers. In addition, sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01001-3
更新日期：1996-12-02 00:00:00
abstract：:Experimental traumatic brain injury (TBI) is known to produce an acute increase in cerebral glucose utilization, followed rapidly by a generalized cerebral metabolic depression. The current studies determined effects of single or multiple treatments with sodium pyruvate (SP; 1000mg/kg, i.p.) or ethyl pyruvate (EP; 40m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.04.005
更新日期：2016-07-01 00:00:00
abstract：:Converging evidence suggests that compromised motor abilities in hemiparetic cerebral palsy are not solely due to impairments in motor execution, but are also related to deficits in action planning. The present study had two aims. First, we compared grip planning in a sequential task between participants with left-sid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.074
更新日期：2009-03-19 00:00:00
abstract：:Purkinje cells are the sole output from the cerebellar cortex and play a critical role during classical eyeblink conditioning. The present study revealed for the first time a learning-related change in individual Purkinje cell activity during successive eyeblink conditioning in decerebrate guinea pigs which permitted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.090
更新日期：2006-01-12 00:00:00
abstract：:In rats raised from birth under a regular dark-light cycle, retinal dopamine (DA) levels were low at 12 days, increased progressively and steeply at 16, 20, 30 and 60 days and peaked at about 75 days postnatally. Dark-rearing from birth suppressed the magnitude of the normal developmental pattern of DA concentrations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90293-2
更新日期：1986-05-01 00:00:00
abstract：:The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90791-9
更新日期：1990-10-29 00:00:00
abstract：:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90352-v
更新日期：1991-08-02 00:00:00
abstract：:Bulk-isolated human and bovine oligodendroglia, practically free from myelin, have been used in attempts to elicit an autoimmune response which has been compared with acute experimental allergic encephalomyelitis (EAE). For these experiments, a total of 20 Hartley guinea pigs, 33 Lewis rats and 16 rabbits have been st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90906-4
更新日期：1977-01-21 00:00:00
abstract：:Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03291-7
更新日期：2002-01-25 00:00:00
abstract：:Immunocytochemistry and high-performance liquid chromatography with electrochemical detection (HPLC-ED) were used, more than 76 days after infraorbital nerve (ION) transection, to examine the distribution and density of serotonin-immunoreactive (5-HTIR) axons, as well as serotonin (5-HT) and 5-hydroxyindoleacetic acid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90040-i
更新日期：1990-12-17 00:00:00
abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90014-2
更新日期：1994-09-26 00:00:00
abstract：:Several lines of evidence support a role for nerve growth factor (NGF) in the sympathetic sprouting response that occurs following septal cholinergic denervation of the rat hippocampal formation. The present study was undertaken to compare the distribution of NGF-like immunoreactivity and the topography of sympathetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01344-h
更新日期：1995-02-20 00:00:00
abstract：:The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90682-3
更新日期：1989-04-17 00:00:00
abstract：:Serotoninergic transmission is implicated in the photic and non-photic regulation of circadian rhythms. 5-HT (1-100 microM), carboxamidotryptamine (5-CT 0.1-10 microM) and (+)-8-hydroxy-dipropylaminotetraline (8-OH-DPAT, 1-30 microM) dose-dependently activated an outward current (5-100 pA) in 30% of neurons voltage-cl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02294-0
更新日期：2000-06-02 00:00:00
abstract：:The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90623-4
更新日期：1991-10-25 00:00:00
abstract：:Neurons in the ventromedial tegmental area that project to the rostral part of the dorsal cap of the ipsilateral inferior olive were labeled by the technique of retrograde transport of horseradish peroxidase (HRP). Following iontophoresis of HRP into the rostral part of the dorsal cap a cluster of labeled cells are fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90574-2
更新日期：1979-08-31 00:00:00
abstract：:The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 microliters/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90456-w
更新日期：1993-06-04 00:00:00
abstract：:We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91575-6
更新日期：1985-05-06 00:00:00
abstract：:Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90099-u
更新日期：1992-03-20 00:00:00
abstract：:The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, and we showed previously that it is required for the specificati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.058
更新日期：2008-09-04 00:00:00
abstract：:Visually identified and electrophysiologically characterized sympathetic preganglionic neurons (SPNs) were recorded using the whole-cell voltage clamp technique in slices of neonatal rat spinal cord. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01549-7
更新日期：1998-04-20 00:00:00
abstract：:In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90213-2
更新日期：1988-12-13 00:00:00
abstract：:Huntington׳s Disease (HD) is a fatal neurodegenerative disorder caused by expanded polyglutamine repeats in the Huntingtin (HTT) gene. While the gene was identified over two decades ago, it remains poorly understood why mutant HTT (mtHTT) is initially toxic to striatal medium spiny neurons (MSNs). Models of HD using n...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.001
更新日期：2017-02-01 00:00:00
abstract：:MabQ155, a monoclonal antibody against synaptophysin, has been used to conduct a light microscopic survey of synaptogenesis in the suprachiasmatic nucleus of the perinatal rat. Synaptophysin is an integral component of synaptic vesicle membranes which is expressed in growth cones and growth cone filopodia as well as i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90891-x
更新日期：1991-03-22 00:00:00
abstract：:The present study aimed to evaluate the therapeutic potential of apocynin, an NADPH oxidase assembly inhibitor, on traumatic brain injury. Rat traumatic brain injury (TBI) was performed using a weight drop model. Apocynin (100mg/kg) was injected into the intraperitoneal space 15 min before TBI. Reactive oxygen species...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.08.032
更新日期：2012-10-24 00:00:00
