Genetic causes of amyotrophic lateral sclerosis: new genetic analysis methodologies entailing new opportunities and challenges.

abstract：:Electroconvulsive therapy (ECT) is widely used as a treatment for drug-resistant depression. The animal analogue of ECT is electroconvulsive shock (ECS) seizures. We have recently shown that repeated ECS seizures cause a long-lasting, perhaps permanent, enhancement in entorhinal-dentate evoked potentials in the rat. O...

journal_title：Brain research

authors： Gombos Z,Mendonça A,Racine RJ,Cottrell GA,Burnham WM

更新日期：1997-08-22 00:00:00

abstract：:Biochemical analysis of the binding of [125I]Bolton-Hunter coupled substance P [( 125I]BH-SP) to slide-mounted sections of rat brain demonstrated that [125I]BH-SP labels a binding site with a structure-activity profile characteristic of a substance P receptor. Under optimized preincubation and incubation conditions, t...

journal_title：Brain research

authors： Rothman RB,Herkenham M,Pert CB,Liang T,Cascieri MA

更新日期：1984-08-20 00:00:00

abstract：:In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...

journal_title：Brain research

authors： Su TZ,Campbell GW,Oxender DL

更新日期：1997-05-16 00:00:00

abstract：:The density of specific prostaglandin E2 (PGE2) binding sites was quantitatively mapped in the rat brain using in vitro autoradiography. The anterior wall of the third ventricle and the nucleus solitary tract were found to have a very high density of binding sites (greater than 15 fmol/mg tissue). Two thalamic nuclei ...

journal_title：Brain research

authors： Matsumura K,Watanabe Y,Imai-Matsumura K,Connolly M,Koyama Y,Onoe H,Watanabe Y

更新日期：1992-05-29 00:00:00

abstract：:To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined...

journal_title：Brain research

authors： Jin W,Sugaya A,Tsuda T,Ohguchi H,Sugaya E

更新日期：2000-03-31 00:00:00

abstract：:Previous immunocytochemical, physiological, and molecular studies have reported that the Syrian hamster lacks a shortwave-sensitive (S) cone photopigment but retains circadian responses to ultraviolet (UV) light. Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colo...

journal_title：Brain research

authors： Glösmann M,Ahnelt PK

更新日期：2002-03-01 00:00:00

abstract：:Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...

journal_title：Brain research

authors： Mufson EJ,Labbe R,Stein DG

更新日期：1987-01-13 00:00:00

abstract：:Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter. Mutations in parkin are the most common cause of early-onset autosomal recessive Parkinson's disease, however the function of PACRG an...

journal_title：Brain research

authors： Brody KM,Taylor JM,Wilson GR,Delatycki MB,Lockhart PJ

更新日期：2008-03-27 00:00:00

abstract：:Scratching elicited by the intrathecal (i.t.) administration of substance P (SP) into the lumbosacral spinal cord of rats was not reduced by spinalization or i.t. pretreatment with the analgesic morphine. Spinalization also did not affect scratching elicited by i.t. kainic acid and potentiated scratching elicited by i...

journal_title：Brain research

authors： Bossut D,Frenk H,Mayer DJ

更新日期：1988-07-12 00:00:00

abstract：:Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...

journal_title：Brain research

authors： Reznikov LR,Reagan LP,Fadel JR

更新日期：2009-02-23 00:00:00

abstract：:We have previously demonstrated that Fos immunoreactivity can be stimulated by KCl, forskolin or glutamate in cultured tyrosine hydroxylase-immunoreactive (TH-ir) hypothalamic neurons. The present study was performed to determine whether agents that regulate dopaminergic activity, particularly D1 and D2 receptor agoni...

journal_title：Brain research

authors： Sim LJ,Selley DE,Tsai KP,Morris M

更新日期：1994-07-18 00:00:00

abstract：:We have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. Cisplatin administration resulted in c-fos-like immunoreactivity (FLI) in...

journal_title：Brain research

authors： Reynolds DJ,Barber NA,Grahame-Smith DG,Leslie RA

更新日期：1991-11-29 00:00:00

abstract：:The effects of the imidazothienodiazepinone Ro 19-4603 were investigated in mice. Ro 19-4603 (0.03-0.3 mg/kg) caused a dose-related reduction in seizure threshold to i.v. bicuculline. Doses of 0.1-3 mg/kg induced seizures in some but not all mice, consistent with its suggested action as a partial benzodiazepine recept...

journal_title：Brain research

authors： Lister RG,Durcan MJ

更新日期：1989-03-13 00:00:00

abstract：:In the quinolinic acid (QA)-rat model of Huntington's disease (HD), 15 days after QA injection, striatal glutamate, measured by in vivo microdialysis, was unchanged while a significant decrease in adenosine occurred. The decrease in adenosine may depend on QA-induced striatal cell loss. Probe perfusion of the adenosin...

journal_title：Brain research

authors： Gianfriddo M,Corsi C,Melani A,Pèzzola A,Reggio R,Popoli P,Pedata F

更新日期：2003-07-25 00:00:00

abstract：:The potential evoked at the surface of the cerebral cortex of a guinea pig, by stimulation of the contralateral forepaw, usually consists of an initial double positive wave whose waveform remains unchanged during rapid stimulation. In a guinea pig with experimental allergic encephalomyelitis (EAE) the response is atte...

journal_title：Brain research

authors： Lumsden CE,Howard L,Aparicio SR

更新日期：1975-08-08 00:00:00

abstract：:This study examined whether cardiac beta-adrenoceptor (beta-AR) function was altered in conscious rats with lesions surrounding the anteroventral third ventricle (AV3V). The findings were: (1) beta(1,2)-AR-mediated tachycardia was similar in sham and AV3V-lesion rats, (2) beta(3)- and/or atypical beta-AR-mediated tach...

journal_title：Brain research

authors： Whalen EJ,Schoorlemmer GH,Beltz TG,Johnson AK,Lewis SJ

更新日期：2001-09-14 00:00:00

abstract：:The distribution of fast axonally transported proteins was studied by electron microscope radioautography in ciliary ganglia of chickens treated or not treated with acrylamide. At 3 h after the intracerebral injection of [3H]lysine, the preganglionic axons of the untreated chickens displayed few silver grains, mainly ...

journal_title：Brain research

authors： Chretien M,Patey G,Souyri F,Droz B

更新日期：1981-01-26 00:00:00

abstract：:Acute forebrain ischemia reduced protein kinase C (PKC) activity in the adult rat cortex, striatum and hippocampus by 60-70% after 20 min ischemia episodes, followed by 48 h of recirculation. Ischemia of 1 min, followed by recirculation, produced a less pronounced but significant decrease in PKC activity. The ischemia...

journal_title：Brain research

authors： Louis JC,Magal E,Brixi A,Steinberg R,Yavin E,Vincendon G

更新日期：1991-02-08 00:00:00

abstract：:Bilateral removal of the cortical visual area in newborn cats produces degeneration of retinal ganglion cells. Measurements of over 4,000 cells and calculation of neuron densities from sample areas of retina in the adult show that the medium sized cell population in peripheral retina is reduced by 68%, whereas the pop...

journal_title：Brain research

authors： Pearson HE,Labar DR,Payne BR,Cornwell P,Aggarwal N

更新日期：1981-05-18 00:00:00

abstract：:The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) and glaucoma. Initial in vitro studies on brain membranes showed that EGCG was appro...

journal_title：Brain research

authors： Zhang B,Osborne NN

更新日期：2006-12-08 00:00:00

abstract：:Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologi...

journal_title：Brain research

authors： Théorêt Y,Earnhardt TS,Bouldin TW,Krigman MR

更新日期：1988-05-24 00:00:00

abstract：:The concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decre...

journal_title：Brain research

authors： Glaser J,Russell VA,Taljaard JJ

更新日期：1992-04-17 00:00:00

abstract：:Previous immunocytochemical studies have shown immunological differences between neurofilaments in axons and those in dendrites and perikarya of many mature neuron types: it is now known that non-phosphorylated epitopes are normally seen in cell bodies and dendrites of mature neurons, whereas phosphorylated epitopes a...

journal_title：Brain research

authors： Shaw G,Winialski D,Reier P

更新日期：1988-09-20 00:00:00

abstract：:Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other parts of the brain. Cerebral blood flow mapping was performed using [...

journal_title：Brain research

authors： Wang Z,Guo Y,Mayer EA,Holschneider DP

更新日期：2019-08-15 00:00:00

abstract：:We determined whether pentobarbital anesthetic is required to culture postmortem adult rat neurons. Pentobarbital treatment resulted in two-fold increases in neuron survival in culture after 2 and 4 h postmortem compared to non-anesthetic controls, but was not as effective as simple postmortem treatment on ice and the...

journal_title：Brain research

authors： Viel JJ,McManus DQ,Brewer GJ

更新日期：2004-05-29 00:00:00

abstract：:The microdialysis technique was utilized to study the effects of N-methyl-D-aspartate (NMDA) receptor ligands on the in vivo release of endogenous glutamate (Glu) and aspartate (Asp) from the rat striatum. Addition of NMDA (250 and 500 microM) to the dialysis perfusion solution resulted in a striking dose-dependent in...

journal_title：Brain research

authors： Bustos G,Abarca J,Forray MI,Gysling K,Bradberry CW,Roth RH

更新日期：1992-07-10 00:00:00

abstract：:Axonal projections of medial brain stem areas rich in serotonin-containing neurons were identified in layers I and II of cat medullary dorsal horn using EM autoradiography. Following [3H]amino acid injections into the brain stem, labeled axonal endings were found throughout layers I and II but were most numerous in la...

journal_title：Brain research

authors： Ruda MA,Allen B,Gobel S

更新日期：1981-01-26 00:00:00

abstract：:We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine. The hypothesis was not supported; the pat...

journal_title：Brain research

authors： Bureau YR,Peredery O,Persinger MA

更新日期：1994-06-20 00:00:00

abstract：:Using one microelectrode inserted into a Limulus retinular cell, simultaneous recordings were made of the receptor potential evoked by light falling on that retinular cell and of the optic nerve action potentials generated in the eccentric cell coupled to that retinular cell. The postreceptor transfer function for sen...

journal_title：Brain research

authors： Wang LT,Wasserman GS

更新日期：1985-02-25 00:00:00

abstract：:The contribution of the activity of afferent fiber filaments to pain and hyperalgesia after administration of a plantar injection of interleukin-1 beta (IL-1 beta) to the hind-paw skin was investigated by recording action potentials of the rat dorsal root in response to mechanical and thermal stimuli. Touch stimuli we...

journal_title：Brain research

authors： Fukuoka H,Kawatani M,Hisamitsu T,Takeshige C

更新日期：1994-09-19 00:00:00