Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease.

abstract：:The epileptogenic properties of the mast cell degranulating peptide (MCD) have been investigated in the CA3 region of the hippocampal slice preparation. Brief (3-5 min) bath application of MCD (0.5-2 microM) to CA3 hippocampal neurones produced an enhancement of the spontaneous synaptic activity and the appearance of ...

journal_title：Brain research

authors： Cherubini E,Neuman R,Rovira C,Ben Ari Y

更新日期：1988-03-29 00:00:00

abstract：:This study attempted to ascertain whether heatstroke-induced ischemia is associated with augmented striatal glutamate release and can be attenuated by NMDA receptor antagonists. Mean arterial pressure (MAP), striatal cerebral blood flow (CBF), striatal glutamate release and striatal neuronal damage score were assessed...

journal_title：Brain research

authors： Yang YL,Pan WH,Chiu TH,Lin MT

更新日期：1998-06-08 00:00:00

abstract：:The role of the cerebellum and the red nucleus in the conditioned eyeblink response was assessed, using a combination of reversible lesions and multiple-unit extracellular recording in the awake, behaving rabbit. Lesion, recording, and stimulation experiments have indicated that both of these structures are involved i...

journal_title：Brain research

authors： Chapman PF,Steinmetz JE,Sears LL,Thompson RF

更新日期：1990-12-24 00:00:00

abstract：:A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....

journal_title：Brain research

authors： Clemo HR,Stein BE

更新日期：1982-03-04 00:00:00

abstract：:Previous work has demonstrated that the GABAergic system is involved in sexual differentiation of the rodent hypothalamus. The present study was designed to further examine this involvement by investigating developmental sex differences in GAD(65) protein levels in hypothalamic and extrahypothalamic brain regions know...

journal_title：Brain research

authors： Perrot-Sinal TS,Davis AM,McCarthy MM

更新日期：2001-12-20 00:00:00

abstract：:Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...

journal_title：Brain research

authors： Pomeranz B,Bibic L

更新日期：1988-06-14 00:00:00

abstract：:The alpha-2 adrenergic agonist dexmedetomidine (Dex), 3-300 microg/kg, i.p., decreased cerebellar cGMP in a dose-dependent manner. Fentanyl (F), an opioid agonist, increased cerebellar cGMP at 0.3 mg/kg, s.c., and decreased it at doses >/=1 mg/kg. The inhibitory effect was receptor specific, that of Dex being blocked ...

journal_title：Brain research

authors： Vulliemoz Y,Virag L,Whittington RA

更新日期：1998-11-30 00:00:00

abstract：:In order to obtain further insight into the interactions between the purinergic and dopaminergic pathways in the striatum, we studied both metabolisms simultaneously, using a microdialysis technique in 1-methyl-1,4-phenylpyridinium ion (MPP+) unilaterally-denervated conscious rats. In these rats the contralateral side...

journal_title：Brain research

authors： Ballarin M,Reiriz J,Ambrosio S,Camps M,Blesa R,Mahy N

更新日期：1989-03-27 00:00:00

abstract：:The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...

journal_title：Brain research

authors： Kasckow JW,Parkes DG,Owens MJ,Stipetic MD,Han JH,Nemeroff CB,Vale WW

更新日期：1994-08-15 00:00:00

abstract：:The morphological and physiological identification of the cells in the inner retina of Japanese dace was made by means of intracellular single cell recording and dye injection techniques. Our flat mounts and physiological classification revealed that 97 out of 102 sample cells were amacrine cells except for 3 transien...

journal_title：Brain research

authors： Chino YM,Hashimoto Y

更新日期：1986-05-07 00:00:00

abstract：:Human arachnoid villi were studied ultrastructurally to clarify the mechanism of cerebrospinal fluid absorption. Arachnoid villi of humans showed quite different features from those of animals. The former were not always invested with endothelial linings as previously reported in the latter. Instead, there was a cover...

journal_title：Brain research

authors： Yamashima T

更新日期：1986-10-01 00:00:00

abstract：:The opposing actions of diphenylhydantoin (DPH) and calcium on the level of [32P]phosphate incorporation into particular rat and human brain proteins have been demonstrated in this study by employing the techniques of acrylamide gel electrophoresis and autoradiography. In the presence of calcium several brain proteins...

journal_title：Brain research

authors： DeLorenzo RJ

更新日期：1977-09-23 00:00:00

abstract：:Climbing fiber responses (CFRs) evoked by white matter stimulation and parallel fiber responses (PFRs) elicited by the stimulation of the surface of the folium were compared using intracellular recording from the dendrites of Purkinje cells in the in vitro slice preparation of the guinea pig cerebellum. Intracellular ...

journal_title：Brain research

authors： Kimura H,Okamoto K,Sakai Y

更新日期：1985-12-02 00:00:00

abstract：:Voltage-clamped GABA(A fast) and GABA(A slow) inhibitory postsynaptic currents (IPSCs) were selectively elicited in hippocampal area CA1 pyramidal neurons. Clinically relevant concentrations of halothane (1.2 vol.%) prolonged both GABA(A fast) and GABA(A slow) IPSC decay times approximately 2.5 fold, while having litt...

journal_title：Brain research

authors： Lukatch HS,MacIver MB

更新日期：1997-08-08 00:00:00

abstract：:Cytogenesis in the kitten retina has been investigated with [3H]thymidine autoradiography and a stain for mitotic figures. The nuclei of cells in S-phase are located adjacent to the inner margin of the cytoblast layer, near the inner plexiform layer. The nuclei then migrate toward the outer limiting membrane (OLM) to ...

journal_title：Brain research

authors： Robinson SR,Rapaport DH,Stone J

更新日期：1985-03-01 00:00:00

abstract：:Previous immunocytochemical studies have shown immunological differences between neurofilaments in axons and those in dendrites and perikarya of many mature neuron types: it is now known that non-phosphorylated epitopes are normally seen in cell bodies and dendrites of mature neurons, whereas phosphorylated epitopes a...

journal_title：Brain research

authors： Shaw G,Winialski D,Reier P

更新日期：1988-09-20 00:00:00

abstract：:Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The rem...

journal_title：Brain research

authors： Charpak S,Armstrong WE,Mühlethaler M,Dreifuss JJ

更新日期：1984-05-21 00:00:00

abstract：:The formation of synapses in cell cultures of rat cerebellum was examined in the presence of the protein synthesis inhibitor cycloheximide. First, cell survival in the presence of 25 micrograms/ml cycloheximide was determined by phase contrast microscopy, trypan blue exclusion, total protein and uptake of [3H]gamma-am...

journal_title：Brain research

authors： Burry RW

更新日期：1985-09-30 00:00:00

abstract：:The cell-mediated inflammatory component of experimental autoimmune encephalomyelitis (EAE) in mice is measured by the radioisotopic technique. Mice are challenged with autologous spinal cord homogenate in Freund's complete adjuvant and at various time intervals after such immunization given [125I]5-iodo-2'-deoxyuridi...

journal_title：Brain research

authors： Linthicum DS,Horvath L,Carnegie PR

更新日期：1979-10-05 00:00:00

abstract：:The location of stapedius motoneurons in the rat was determined with horseradish peroxidase (HRP) retrograde tracing techniques. After injection of free HRP or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the stapedius muscle on one side, labeled neurons were seen ipsilaterally in a region ventromedial to...

journal_title：Brain research

authors： Rouiller EM,Capt M,Dolivo M,De Ribaupierre F

更新日期：1989-01-02 00:00:00

abstract：:Immunohistochemical studies have suggested that corticotropin-releasing factor (CRF) was a transmitter of the olivocerebellar projection. We used in situ hybridization histochemistry with a 35S-labeled oligodeoxyribonucleotide probe for CRF mRNA to show that inferior olivary neurons of rats, baboons, and humans synthe...

journal_title：Brain research

authors： Young WS 3rd,Walker LC,Powers RE,De Souza EB,Price DL

更新日期：1986-11-01 00:00:00

abstract：:Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. Thes...

journal_title：Brain research

authors： Mourre C,Fournier C,Soumireu-Mourat B

更新日期：1997-12-19 00:00:00

abstract：:A complete gap of 3-4 mm was surgically created in the spinal cord of adult rats between the T8-T10 vertebral level, filled with a collagen matrix and closed with sutures. Animals were killed at weekly intervals from 14 to 42 days postimplantation. The collagen implant (CI) was evaluated for ingrowth of blood vessels ...

journal_title：Brain research

authors： Gelderd JB

更新日期：1990-03-12 00:00:00

abstract：:Noxious heat applied to the footpad evokes the expression of fos protein-like immunoreactivity in the rat spinal cord lumbar dorsal horn. Electrical stimulation in the medullary nucleus raphe magnus (NRM) while not evoking fos-like immunoreactivity itself, reduced significantly the number of neurons (to 50% of control...

journal_title：Brain research

authors： Jones SL,Light AR

更新日期：1990-10-22 00:00:00

abstract：:Our previous studies indicated that L-type calcium channel blocker diltiazem could potentiate pentobarbital-induced hypnosis through serotonergic system. In view of the important role of dorsal raphe nucleus (DRN) on the sleep regulation and the pharmacological actions of calcium channel blocker, we presumed that Ca(2...

journal_title：Brain research

authors： Cui SY,Cui XY,Zhang J,Wang ZJ,Yu B,Sheng ZF,Zhang XQ,Shi XL,Zhang YH

更新日期：2011-07-27 00:00:00

abstract：:The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...

journal_title：Brain research

authors： Pilowsky PM,Kapoor V,Minson JB,West MJ,Chalmers JP

更新日期：1986-02-26 00:00:00

abstract：:In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...

journal_title：Brain research

authors： Britt RH

更新日期：1976-08-13 00:00:00

abstract：:This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...

journal_title：Brain research

authors： Hernandez DE,Emerick SG

更新日期：1988-08-30 00:00:00

abstract：:Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-...

journal_title：Brain research

authors： Ortiz AN,Osterhaus GL,Lauderdale K,Mahoney L,Fowler SC,von Hörsten S,Riess O,Johnson MA

更新日期：2012-04-23 00:00:00

abstract：:Cultured cells derived from Tay-Sachs disease (TSD) fetal cerebellum were shown to accumulate GM2 ganglioside when compared with control cultures. In contrast, fibroblasts derived from TSD fetal lung do not contain GM2. GM2 was identified by thin-layer chromatography (TLC) and confirmed by gas-liquid chromatography (G...

journal_title：Brain research

authors： Hoffman LM,Amsterdam D,Schneck L

更新日期：1976-07-23 00:00:00