Abstract：
:This study examined whether cardiac beta-adrenoceptor (beta-AR) function was altered in conscious rats with lesions surrounding the anteroventral third ventricle (AV3V). The findings were: (1) beta(1,2)-AR-mediated tachycardia was similar in sham and AV3V-lesion rats, (2) beta(3)- and/or atypical beta-AR-mediated tachycardia elicited by isoproterenol (10 microg/kg, i.v.; ISO) was diminished in AV3V-lesion rats treated with beta(1,2)-AR antagonists, but was not in similarly-treated sham-lesion rats, and (3) the tachycardia elicited by the membrane permeable cAMP-analogue, 8-(4-chlorophenylthiol)-cAMP (10 micromol/kg, i.v.), was similar in AV3V- and sham-lesion rats. The possibility that increased plasma sodium/osmolality in AV3V-lesion rats down-regulated cardiac beta(3)- and/or atypical beta-ARs, but not beta(1,2)-ARs or intracellular cAMP signaling is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Whalen EJ,Schoorlemmer GH,Beltz TG,Johnson AK,Lewis SJdoi
10.1016/s0006-8993(01)02744-5subject
Has Abstractpub_date
2001-09-14 00:00:00pages
82-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02744-5journal_volume
913pub_type
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