Abstract：
:The aim of this study was to examine: (1) whether long-term potentiation (LTP) can be induced in slices from adult rat visual cortex under conditions where inhibition is not antagonized, and (2) the role of N-methyl-D-aspartate (NMDA) receptors in its induction. The field potential elicited in layer III in response to stimulation of the subcortical white matter consisted of a component with peak latency 5-8 ms (N1) and, in most slices, a second component with peak latency 13-19 ms (N2). N1 was generated via both kainate/alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and NMDA receptor activation as revealed by bath application of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). N2 was insensitive to APV in most of the slices and was probably polysynaptic since it did not follow stimulation at 0.5 Hz. Tetanic stimulation of the white matter in normal medium induced LTP of N1; in some slices N2 also potentiated. Tetanic stimulation in the presence of APV also induced LTP of N1 and sometimes N2. LTP of N1 induced in APV was of a larger magnitude, and was expressed more quickly than LTP induced in normal medium. It appears that the known reduction of NMDA receptor activity in adult neocortex is accompanied by the development of other mechanisms that maintain synaptic plasticity; these mechanisms seem to operate more efficiently in absence of NMDA receptor activation.
journal_name
Brain Resjournal_title
Brain researchauthors
Aroniadou VA,Teyler TJdoi
10.1016/0006-8993(92)90891-csubject
Has Abstractpub_date
1992-07-03 00:00:00pages
169-73issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90891-Cjournal_volume
584pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:It is well known that locus coeruleus (LC) of the rat shows intense mu-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey (Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in oth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00191-1
更新日期：1997-05-02 00:00:00
abstract：:The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91368-3
更新日期：1993-03-05 00:00:00
abstract：:The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we re...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.08.038
更新日期：2007-05-18 00:00:00
abstract：:Spinal cord injury (SCI) often results in some form of paralysis. Recently, SCI therapy has been focused on preventing secondary injury to reduce both neuroinflammation and lesion size so that functional outcome after an SCI may be improved. Previous studies have shown that adenosine receptors (AR) are a major regulat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.12.053
更新日期：2016-03-01 00:00:00
abstract：:Oxidative stress has been implicated as a pathogenic mediator of neuronal perikarya cell death. Axons and oligodendrocytes, components of white matter, could also be vulnerable to oxidative damage. An experimental model of oxidative stress was induced by systemic injection of 3-nitropropionic acid (3-NPA). Animals rec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03266-2
更新日期：2001-02-23 00:00:00
abstract：:Extracellular levels of acetylcholine (ACh) were measured in the central nucleus of the amygdala using microdialysis in 20-min intervals before, during, and after 1 h feeding in food-deprived rats. The results were compared to the effects of peripheral injections of glucose or 'low' (200 mU) and 'high' (1 U) doses of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01291-2
更新日期：1998-02-23 00:00:00
abstract：:Studies were conducted to assess whether stimulation of dopamine receptors located in the globus pallidus might play a role in mediating the enhanced pallidal activity seen after systemic administration of dopamine agonists or D-amphetamine. Dopamine, applied iontophoretically, had modest effects on the activity of pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90006-4
更新日期：1984-09-17 00:00:00
abstract：:p-Chlorophenylalanine was administered to rats to inhibit hepatic phenylalanine hydroxylase activity. Two days later, phenylalanine injection was noted to produce substantial increases in serum phenylalanine levels, and relatively modest increments in serum tyrosine levels. Rats injected with p-chlorophenylalanine 2 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90777-4
更新日期：1989-10-16 00:00:00
abstract：:Variation in cell loss and mossy fiber reorganization was examined along the longitudinal axis of the dentate gyrus from temporal lobe epileptic (TLE) patients. Previous evidence has indicated that the anterior hippocampus is prone to seizure activity. We compared granule and hilar cell number in addition to Timm stai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00167-o
更新日期：1995-04-24 00:00:00
abstract：:The two human brain beta-galactosidases were solubilized and fractionated by Sephadex G-200 gel filtration, free from each other. Substrate specificities of the two enzymes were examined for galactosylceramide, lactosyl-[N-stearoyl]ceramide, lactosyl-[N-lignoceroyl]ceramide, galactosyl-N-acetylgalactosaminyl-[N-stearo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90298-0
更新日期：1977-02-18 00:00:00
abstract：:Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90010-8
更新日期：1988-06-14 00:00:00
abstract：:Cytochemistry was used to examine the distribution of two pathways of utilization of hydrogen (Type I and Type II H) generated by glucose-6-phosphate dehydrogenase (G6PD) in circumventricular organs (CVOs) and the hypothalamo-neurohypophysial system in cryostat sections of rat brain. Type I H is defined as that portio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91306-4
更新日期：1984-02-27 00:00:00
abstract：INTRODUCTION:Ischemic postconditioning (IpostC) has been described in both heart and brain. The first aim of this study was to evaluate the effects of IpostC on brain infarct size and neurological function in the middle cerebral artery occlusion (MCAO) model. The second aim was to determine the involvement of the mitoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.054
更新日期：2011-02-23 00:00:00
abstract：:Unilateral nigrostriatal lesions were performed in rats by punctate injection of 6-hydroxydopamine. Lesioned animals exhibited anorexia and weight loss for 7-11 days after surgery. These animals then displayed normal rate of weight gain. However, there was a chronic depression of body weight in the lesioned animals re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90195-0
更新日期：1977-09-02 00:00:00
abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91444-6
更新日期：1991-12-13 00:00:00
abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90223-4
更新日期：1986-08-20 00:00:00
abstract：:The effects of GM1 ganglioside (30 mg/kg i.p.) administration for 22 days on choline acetyltransferase (ChAT) activity and noradrenaline (NA) levels in the cerebral cortex and on the acquisition of active and passive avoidance-conditioned responses were investigated in both sham-operated rats and in rats with a unilat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90246-x
更新日期：1985-07-08 00:00:00
abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00706-v
更新日期：1995-10-09 00:00:00
abstract：:We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy. In the dose range of 0.75 to 10 mg/kg s.c., KA dose-dependently induced characteristic behavioural changes. Partial depletion of noradrenaline (NA) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90219-9
更新日期：1989-08-28 00:00:00
abstract：:The effects of natural (mechanical and gustatory) stimulation of the nasopharynx or electrical stimulation of the pharyngeal branch of the glossopharyngeal (PH-IXth) nerve on the changes in heart rate (HR) and arterial blood pressure (BP) were investigated in paralyzed and anesthetized rats. Afferent responses in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91614-x
更新日期：1993-08-13 00:00:00
abstract：:Using bilateral infusions into the rat striatum, the effects of the competitive NMDA receptor antagonist 2-amino-5-phosphopentanoic acid (AP5) on behaviors induced by the dopamine (DA) D1 receptor agonist SKF 82526 (fenoldopam) or the D2 receptor agonist quinpirole were determined. These effects were tested in DA-repl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00630-0
更新日期：1996-11-11 00:00:00
abstract：:Acupuncture is widely used to relieve pain; however, the mechanism underlying electroacupuncture analgesia (EAA) during inflammatory pain is unclear. We investigated whether endogenous peripheral opioid receptors participated in EAA during hyperalgesia elicited by carrageenan-induced inflammation. Moreover, we investi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.014
更新日期：2010-10-08 00:00:00
abstract：:Microinjection of the indirect GABAA antagonist, picrotoxin, or the mu opioid agonist, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO), into the ventral pallidum and substantia innominata (VP/SI) increases locomotor activity in rats. The VP/SI has direct and indirect projections to the region of the ventral mesencephalon containi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91005-l
更新日期：1991-02-22 00:00:00
abstract：:The morphological characteristics, distribution and neurochemical phenotype of striatal neuronal subtypes expressing the GABA(A) receptor alpha3-subunit were investigated using immunocytochemical and immunofluorescent techniques with an antibody specific for this subunit. alpha3-immunopositive neurons were infrequent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02636-6
更新日期：2000-09-08 00:00:00
abstract：:The total number of neurosensory cells in the mouse vomeronasal organ was estimated during postnatal development by counting the cell density and measuring the total volume of the neurosensory cell layer. There is a 43% increase in neurosensory cell number between 1 and 4 months of age, followed by a 21% fall in cell ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90675-7
更新日期：1980-03-03 00:00:00
abstract：:In urodele amphibians, the hypothalamic neuropeptide arginine vasotocin and the adrenal steroid corticosterone interact to regulate reproductive behavior by actions in the brain. The present study investigated signal transduction pathways underlying acute effects of vasotocin and corticosterone, presumably mediated vi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.071
更新日期：2007-02-23 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD)) is not known quantitatively. In the present study we compared V(GAD) in cortex of control and vigabatrin-treate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02778-0
更新日期：2001-09-28 00:00:00
abstract：:Autoradiographic localization of binding sites for [3H]prostaglandin D2, E2 and F2 alpha in the monkey brain was investigated by using in vitro labeling and an image processing system. Specific binding sites were distinctly localized in various nuclei in the hypothalamus, thalamus, and limbic system and their localiza...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91486-8
更新日期：1989-01-23 00:00:00
abstract：:Based on the fact that several recent reports have indicated that non-immunosuppressive immunophilin ligands (IPLs) can activate neurite outgrowth or nerve regeneration, we investigated the neurotrophic factor-activating abilities of IPLs in vivo in order to clarify the molecular basis of neurotrophic-like activity. B...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02434-x
更新日期：2003-04-25 00:00:00
abstract：:We showed previously, using in vitro microdialysis, that the activation of the soluble guanylate cyclase (sGC)/cyclic GMP pathway was the underlying mechanism of the extracellular Ca(2+)-dependent effects of exogenous NO on dopamine (DA) secretion from PC12 cells. In this study, the co-infusion of the sGC inhibitor 1H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.040
更新日期：2004-10-15 00:00:00
