Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy.

abstract：:Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...

journal_title：Brain research

authors： Omote K,Kawamata T,Kawamata M,Namiki A

更新日期：1998-12-14 00:00:00

abstract：:Distribution of adult T cell leukemia derived factor (ADF/TRX), a human thioredoxin homologue, was studied by immunohistochemistry in gerbil brain during reperfusion after transient cerebral ischemia. In control brains, immunoreactivity was observed widely in the central nervous system, including the ependyma, tanycyt...

journal_title：Brain research

authors： Tomimoto H,Akiguchi I,Wakita H,Kimura J,Hori K,Yodoi J

更新日期：1993-10-15 00:00:00

abstract：:The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...

journal_title：Brain research

authors： Wild JM

更新日期：1997-06-06 00:00:00

abstract：:Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...

journal_title：Brain research

authors： Marwaha J,Kehne JH,Commissaris RL,Lakoski J,Shaw W,Davis M

更新日期：1983-10-16 00:00:00

abstract：:The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in...

journal_title：Brain research

authors： Mikkelsen M,Harris AD,Edden RAE,Puts NAJ

更新日期：2018-12-15 00:00:00

abstract：:The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE-ligand interaction has a putative role in a range of chronic disorders and is also known to contribute to both inflammatory/degenerative processes as well as regenerati...

journal_title：Brain research

authors： Ma L,Carter RJ,Morton AJ,Nicholson LF

更新日期：2003-03-21 00:00:00

abstract：:Immobilization of frogs for 1 h induces analgesia which is blocked but not reversed by low doses of naloxone. After 9 days of daily immobilization for 1 h, the treatment fails to cause analgesia thus indicating that tolerance has developed. Animals tolerant to immobilization-induced analgesia do not show cross-toleran...

journal_title：Brain research

authors： Pezalla PD,Dicig M

更新日期：1984-04-02 00:00:00

abstract：:By utilizing the microinjection of low nanoliter volumes of convulsant drug and recording from the injection site, we have been able to electrophysiologically identify a layer of cat striate cortex that is most sensitive to the epileptogenic effects of penicillin. This band encompasses cortical depths of approximately...

journal_title：Brain research

authors： Chatt AB,Ebersole JS

更新日期：1982-06-10 00:00:00

abstract：:The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...

journal_title：Brain research

authors： Graybiel AM

更新日期：1975-10-10 00:00:00

abstract：:In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system (CNS), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits (Tg6074) the other showing no neurological or phenotypical alterations (TgK3) to inv...

journal_title：Brain research

authors： Aloe L,Properzi F,Probert L,Akassoglou K,Kassiotis G,Micera A,Fiore M

更新日期：1999-09-04 00:00:00

abstract：:The effect of intraocular injection of the neurotoxin, kainic acid, on the retinofugal pathway has been examined by anterograde transport of horseradish peroxidase. Although less peroxidase was present in all the primary optic centers after the intraocular injection of kainic acid than in the controls, the area occupi...

journal_title：Brain research

authors： Gomez-Ramos P,Perez-Rico C,Reinoso-Suarez F

更新日期：1984-01-09 00:00:00

abstract：:Mitochondrial division inhibitor (mdivi-1), a selective inhibitor of a mitochondrial fission protein dynamin-related protein 1 (Drp1), has been shown to exert protective effects in heart and cerebral ischemia-reperfusion models. The present study was designed to investigate the beneficial effects of mdivi-1 against sp...

journal_title：Brain research

authors： Liu JM,Yi Z,Liu SZ,Chang JH,Dang XB,Li QY,Zhang YL

更新日期：2015-09-04 00:00:00

abstract：:Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologi...

journal_title：Brain research

authors： Théorêt Y,Earnhardt TS,Bouldin TW,Krigman MR

更新日期：1988-05-24 00:00:00

abstract：:In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...

journal_title：Brain research

authors： Gross-Isseroff R,Israeli M,Biegon A

更新日期：1988-07-19 00:00:00

abstract：:The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...

journal_title：Brain research

authors： Gerashchenko D,Shiromani PJ

更新日期：2004-09-03 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) has been shown to activate the hypothalamo-pituitary-adrenal axis, possibly by a direct action on hypothalamic CRF synthesis and release. In order to study the mechanisms involved in this effect, foetal hypothalamic cells were cultured and corticotropin-releasing factor-41 (CRF) release was ...

journal_title：Brain research

authors： Hu SB,Lightman SL,Tannahill LA

更新日期：1992-03-06 00:00:00

abstract：:The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 microliters/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid ...

journal_title：Brain research

authors： Yoshioka M,Matsumoto M,Togashi H,Smith CB,Saito H

更新日期：1993-06-04 00:00:00

abstract：:Electroconvulsive stimulation (ECS), the experimental analogue of electroconvulsive therapy (ECT), has been shown to produce both functional and structural effects in the hippocampal formation in infrahuman species. These changes may relate to the antidepressant and cognitive effects of ECT observed in patients treate...

journal_title：Brain research

authors： Lamont SR,Stanwell BJ,Hill R,Reid IC,Stewart CA

更新日期：2005-08-16 00:00:00

abstract：:The immunocytochemical localization of L-glutamate decarboxylase (GAD), the enzyme which which forms gamma-aminobutyric acid (GABA), has been studied in developing rodent cerebellum. During the first 3-4 postnatal days, GAD is distributed along non-terminal portions of axonal processes in close association with small ...

journal_title：Brain research

authors： McLaughlin BJ,Wood JG,Saito K,Roberts E,Wu JY

更新日期：1975-03-07 00:00:00

abstract：:The anatomical structure of the basal ganglia indicates that the input from the cerebral cortex is funnelled through the striatum to the globus pallidus and substantia nigra. This structure implies integration of the information as it is transferred through the basal ganglia. In order to investigate this integration, ...

journal_title：Brain research

authors： Loopuijt LD,van der Kooy D

更新日期：1985-11-25 00:00:00

abstract：:In pentobarbital-anesthetized rats, responses of single neurons in ventrolateral orbital cortex (VLO) to noxious visceral (colorectal distension, CRD) and cutaneous stimulation were recorded. Of 71 neurons identified on the basis of spontaneous activity, 44 responded to CRD. CRD caused inhibition of neuronal activity ...

journal_title：Brain research

authors： Follett KA,Dirks B

更新日期：1995-01-16 00:00:00

abstract：:Axonal flow of motoneurons was blocked in the sciatic nerve by the application of vinblastine at a low concentration (100 microM) not considered likely to cause axonal degeneration. The number of motoneurons expressing alpha-calcitonin gene-related peptide (CGRP) mRNA was significantly increased by vinblastine applica...

journal_title：Brain research

authors： Katoh K,Tohyama M,Noguchi K,Senba E

更新日期：1992-12-18 00:00:00

abstract：:We examined the distribution of myelin antigens recognized by monoclonal antibodies (mAbs) 01 and 04 in the developing ventral white matter of the cervical spinal cord of the rat using immunogold-labeled ultrathin cryosections. From the beginning of myelination after birth to multilamellar myelin in adult animals, we ...

journal_title：Brain research

authors： Schiff R,Rosenbluth J

更新日期：1995-07-24 00:00:00

abstract：:The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...

journal_title：Brain research

authors： Mohan Kumar V,Datta S,Chhina GS,Gandhi N,Singh B

更新日期：1984-11-26 00:00:00

abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...

journal_title：Brain research

authors： Alonso G,Assenmacher I

更新日期：1979-07-13 00:00:00

abstract：:Activation of a purinergic P2 receptor by adenosine 5'-triphosphate (ATP) has previously been shown to open a non-selective cation channel with a reversal potential of approximately 0 mV. We examined the effect of P2 receptor activation on voltage-gated ionic currents in acutely isolated CA3 pyramidal neurons from gui...

journal_title：Brain research

authors： Dave S,Mogul DJ

更新日期：1996-04-09 00:00:00

abstract：:Whole-cell voltage-clamp techniques were used to study the comparative effects of delta-9-tetrahydrocannabinol (THC) and its principal metabolite, 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), on the voltage-gated sodium current in neuroblastoma cells. The parent compound markedly depressed the inward sodium cu...

journal_title：Brain research

authors： Turkanis SA,Karler R,Partlow LM

更新日期：1991-09-27 00:00:00

abstract：:After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...

journal_title：Brain research

authors： Zhou HX,Li XY,Li FY,Liu C,Liang ZP,Liu S,Zhang B,Wang TY,Chu TC,Lu L,Ning GZ,Kong XH,Feng SQ

更新日期：2014-10-24 00:00:00

abstract：:Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean +/- S.D. = 1,234 +/- 543 microm(2)). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related pep...

journal_title：Brain research

authors： Ichikawa H,Matsuo S,Terayama R,Yamaai T,Sugimoto T

更新日期：2006-04-12 00:00:00

abstract：:In Long-Evans Cinnamon (LEC) rats of three different ages (7, 13 and 32 weeks old) concentrations of Cu, Zn and Fe were measured in 8 regions of the brain. The LEC groups aged 7 and 13 weeks showed low concentrations of Cu in all regions compared to Long-Evans Agouti (LEA) rats. In 32-week-old LEC rats, however, Cu co...

journal_title：Brain research

authors： Sugawara N,Ikeda T,Sugawara C,Kohgo Y,Kato J,Takeichi N

更新日期：1992-08-21 00:00:00