Abstract：
:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoked DA release was detected by differential pulse amperometry during stimulation of the DA axons. Local treatments with cadmium (100 microM) blocked the evoked DA release (-90%), but substantially increased the basal extracellular DA (+125%). The effects of glutamate agonists NMDA (1 mM) and kainate (0.1 mM), known to increase basal extracellular DA were confirmed (+150% and +60% respectively). It was, however, simultaneously observed that the evoked DA release was inhibited (-80% and -50%, respectively). Amphetamine (1 microM) released DA (+150%) and produced also an increase (+100%) of the evoked DA release. These results, apparently conflicting, show that the two mechanisms releasing dopamine (firing-dependent and not) can be directly and simultaneously observed. These two releasing processes appear to be not strictly antagonist. They are also differently and independently modulated by calcium and by local influences such those conveyed by glutamate.
journal_name
Brain Resjournal_title
Brain researchauthors
Olivier V,Guibert B,Leviel Vdoi
10.1016/0006-8993(95)00706-vsubject
Has Abstractpub_date
1995-10-09 00:00:00pages
1-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)00706-Vjournal_volume
695pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Seizure is a common acute and severe disease in infants and children. Recurrent seizures or persistent seizures may cause irreversible brain damage. Mitogen activated protein kinase (MAPK) signaling pathway is associated with an inflammatory response, however it's involvement in the pathological process of seizures is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146932
更新日期：2020-10-15 00:00:00
abstract：:Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02753-1
更新日期：2002-08-02 00:00:00
abstract：:Conditions for the stimulation of taurine release by illumination or increased K+ concentrations were established. The effect of Mg2+, ruthenium red and verapamil on taurine release induced by both procedures was compared. All these agents antagonize Ca2+-dependent release of neurotransmitters. Illumination-induced re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90054-8
更新日期：1976-09-03 00:00:00
abstract：:Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.048
更新日期：2013-12-02 00:00:00
abstract：:Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91422-2
更新日期：1985-12-16 00:00:00
abstract：:Our previous studies demonstrated that only a few days of housing in an enriched environment increases response strength and paired-pulse depression in the auditory cortex of awake and anesthetized rats [Engineer, N.D., Percaccio, C.R., Pandya, P.K., Moucha, R., Rathbun, D.L., Kilgard, M.P., 2004. Environmental enrich...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.062
更新日期：2007-10-12 00:00:00
abstract：:Multidrug efflux transporters of the ATP-Binding cassette (ABC) family, P-glycoprotein (Pgp), multidrug-resistance associated protein 4 (MRP4) and breast cancer resistance protein (BCRP), located on endothelial cells lining brain vasculature play important roles in limiting movement of substances into and enhancing th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.034
更新日期：2010-10-28 00:00:00
abstract：:In anesthetized, artificially ventilated cats, pretreated with the muscarinic antagonist scopolamine, the effect of naloxone on the efficacy of nicotinic transmission in the superior cervical ganglion was used as a test of endogenous opioid release by the preganglionic axons. The cervical sympathetic trunk (CST) was s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91102-7
更新日期：1991-05-10 00:00:00
abstract：:The effect of chronic ethanol administration on the density of basket cells in the dentate gyrus of mice selectively bred for their sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS) was assessed in two experiments. In addition, the effect of chronic ethanol on the density of dentate granule ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90369-1
更新日期：1988-09-20 00:00:00
abstract：:Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91570-i
更新日期：1993-03-19 00:00:00
abstract：:Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91187-2
更新日期：1981-03-23 00:00:00
abstract：:Intracellular recordings were obtained from facial motoneurons in anesthetized rats. The effects of iontophoretically applied serotonin were compared to those of the excitatory amino acids glutamate and DL-homocysteic acid (DLH), and the inhibitory amino acids, glycine, GABA and muscimol, under various conditions of m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90838-1
更新日期：1982-05-06 00:00:00
abstract：:The possibility of retinotopic organization of pathways of retinal fibers within the optic tract and the tectum of the frog was studied by selective labeling of the retinal fibers with horseradish peroxidase. Within the optic tract the pathways of the ventral, temporal and dorsal retinal fibers were ordered from the d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90097-4
更新日期：1981-02-09 00:00:00
abstract：:Murine cortical cell cultures deprived of glucose for 6-8 h developed extensive neuronal degeneration, apparent both morphologically and by efflux of lactate dehydrogenase to the bathing medium. This neuronal damage could be substantially reduced by addition of D-2-amino-5-phosphonovalerate (D-APV), in a concentration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90179-0
更新日期：1989-04-03 00:00:00
abstract：:The aim of this study was to describe the normal distribution of the water content in several regions of the rat brain and furthermore to determine if global ischemia results in a variable increase in water content in these regions. Water content was determined in 40 regions; in 8 unaffected brains by gravimetry and i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01165-1
更新日期：1997-02-21 00:00:00
abstract：:Following injection of the acylating reagent N-succinimidyl [3H]propionate into the optic nerve of goldfish, labeled protein appeared in the ipsilateral retina and contralateral tectum in a time-dependent manner. Autoradiography indicated the presence of the labeled material in the neuroplasm of the retinal ganglion c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91251-9
更新日期：1983-01-24 00:00:00
abstract：:We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.078
更新日期：2006-11-13 00:00:00
abstract：:The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91256-g
更新日期：1990-01-08 00:00:00
abstract：:The capacity of the dopaminergic nerve system to reinnervate the denervated adult striatum was analyzed in a model of partial 6-hydroxydopamine-induced unilateral lesion of rat substantia nigra pars compacta. Sprouting of dopaminergic fibers entering the ventrolateral part of the striatum from a narrow zone of the ext...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01391-1
更新日期：1996-02-19 00:00:00
abstract：:This study investigated the role of strain and vendor differences on the outcome of focal cerebral ischemia in the rat induced by occlusion of the middle cerebral artery by an intraluminal thread. The cortical infarct volumes (Mean +/- S.E.M.) were: 14.2 +/- 6.2 mm3 in Simonsen Laboratories Sprague-Dawley rats; 84.0 +...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00033-m
更新日期：1995-03-27 00:00:00
abstract：:Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) are well-known transcranial magnetic stimulation (TMS) paradigms used to probe the sensorimotor system. To date, there is a paucity of research examining the reliability of these neurophysiological measures. This information is required...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146394
更新日期：2019-11-15 00:00:00
abstract：:A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90512-6
更新日期：1994-12-30 00:00:00
abstract：:In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.063
更新日期：2007-09-05 00:00:00
abstract：:[1-14C]Octanoate (OCTO) is rapidly extracted from blood and metabolized by brain. Up to 6 min following an intravenous pulse injection the autoradiographic pattern of brain labeling reflects differences in blood flow and energy metabolism. When animals are given OCTO during visual or somatosensory stimulation the auto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90486-x
更新日期：1985-06-03 00:00:00
abstract：:The median preoptic nucleus (MnPN) of the hypothalamus contains sleep-active neurons including sleep-active GABAergic neurons and is involved in the regulation of nonREM/REM sleep. The hypocretinergic (HCRT) neurons of the perifornical-lateral hypothalamic area (PF-LHA) and serotonergic (5-HT) neurons of the dorsal ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.115
更新日期：2008-10-09 00:00:00
abstract：:The multidrug resistance gene (Abcb1) protein product, phosphoglycoprotein (P-gp) is expressed on the luminal surface of capillary endothelial cells of the adult blood-brain barrier (bbb). P-gp is critical for neuroprotection as it actively pumps substrates back into the capillary lumen. The fetal brain represents a p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.016
更新日期：2010-10-21 00:00:00
abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.041
更新日期：2015-05-22 00:00:00
abstract：BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.032
更新日期：2013-08-28 00:00:00
abstract：:Both nictitating membrane extension and eyelid EMG activity were measured during classical conditioning of rabbits to tone-airpuff pairings. Both measures were highly correlated. Over trials, learning criterion was met earlier with eyelid EMG activity than with nictitating membrane extension. Within a trial, eyelid EM...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91419-h
更新日期：1990-04-30 00:00:00
abstract：:Neuropeptides, including substance P (SP), calcitonin gene-related peptide (CGRP) and somatostatin (SS) in dorsal root ganglia (DRG) may play a role in neurogenic inflammation and pain transmission. Adrenal corticosteroids regulate neuropeptide synthesis in some areas of the CNS and may modulate neurogenic inflammatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91347-4
更新日期：1991-11-08 00:00:00
