Abstract：
:Using bilateral infusions into the rat striatum, the effects of the competitive NMDA receptor antagonist 2-amino-5-phosphopentanoic acid (AP5) on behaviors induced by the dopamine (DA) D1 receptor agonist SKF 82526 (fenoldopam) or the D2 receptor agonist quinpirole were determined. These effects were tested in DA-replete (intact) rats and in rats that were receiving injections of the monoamine-depleting drug reserpine. In both intact and reserpinized rats, fenoldopam induced significant sniffing. This effect was attenuated by simultaneous co-infusion of AP5 in the reserpinized rats. Quinpirole induced locomotion, sniffing, and oral behaviors, all of which were attenuated by AP5 co-infusion in the intact rats. In contrast, AP5 enhanced the quinpirole-induced sniffing of reserpinized rats. These findings suggest that distinct D1/glutamate and D2/glutamate relationships exist in the striatum, and that the nature of the latter is influenced by DA tone.
journal_name
Brain Resjournal_title
Brain researchauthors
McPherson RJ,Marshall JFdoi
10.1016/s0006-8993(96)00630-0subject
Has Abstractpub_date
1996-11-11 00:00:00pages
19-25issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)00630-0journal_volume
739pub_type
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