Abstract:
:Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neurons appeared to survive transplantation, there were abundant GABA neurons present in the graft. By 4 weeks, however, all cells had died. Finding ways to prolong survival and promote the appropriate neurotransmitter phenotype is essential if hMSCs are to be clinically useful.
journal_name
Brain Resjournal_title
Brain researchauthors
Suon S,Yang M,Iacovitti Ldoi
10.1016/j.brainres.2006.05.109subject
Has Abstractpub_date
2006-08-23 00:00:00pages
46-51issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)01657-Xjournal_volume
1106pub_type
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