Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease.

Abstract:

:Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neurons appeared to survive transplantation, there were abundant GABA neurons present in the graft. By 4 weeks, however, all cells had died. Finding ways to prolong survival and promote the appropriate neurotransmitter phenotype is essential if hMSCs are to be clinically useful.

journal_name

Brain Res

journal_title

Brain research

authors

Suon S,Yang M,Iacovitti L

doi

10.1016/j.brainres.2006.05.109

subject

Has Abstract

pub_date

2006-08-23 00:00:00

pages

46-51

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(06)01657-X

journal_volume

1106

pub_type

杂志文章
  • Norepinephrine release in the amygdala in response to footshock and opioid peptidergic drugs.

    abstract::These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00795-1

    authors: Quirarte GL,Galvez R,Roozendaal B,McGaugh JL

    更新日期:1998-10-19 00:00:00

  • Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells.

    abstract::Secretion of calcitonin gene-related peptide (CGRP) was studied with the model system of dispersed adult rat trigeminal ganglion cells. Veratridine stimulated secretion of CGRP immunoreactivity. Tetrodotoxin and local anesthetics inhibited veratridine-stimulated peptide secretion. These observations implicate sodium c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91441-1

    authors: Peterfreund RA,Vale WW

    更新日期:1986-08-13 00:00:00

  • The tuberal lateral hypothalamus is a major target for GABAA--but not GABAB-mediated control of food intake.

    abstract::The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.05.064

    authors: Turenius CI,Charles JR,Tsai DH,Ebersole PL,Htut MH,Ngo PT,Lara RN,Stanley BG

    更新日期:2009-08-04 00:00:00

  • The response of rabbit ciliary nerve to luminance intensity.

    abstract::Using cervical sympathectomized and immobilized rabbits, the relationship between the luminance intensity and the magnitude of the response in pupillo-constrictor units of the ciliary nerve was investigated. It was revealed that the intensity--response relationship of the units closely resembled that of retinal recept...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90787-8

    authors: Inoue T

    更新日期:1980-11-10 00:00:00

  • Central alpha-adrenergic receptors and corticotropin releasing factor mediate hemodynamic responses to acute cold stress.

    abstract::Behavioral stress is likely to contribute to the development of hypertension in susceptible individuals. We reported that hemodynamic response patterns to acute startle vary and that those patterns predict the predisposition of rats to sustained stress-induced elevations in arterial pressure. Since considerable eviden...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02226-1

    authors: Tan Y,Gan Q,Knuepfer MM

    更新日期:2003-04-04 00:00:00

  • Ascending dopaminergic projections from the dorsal raphe nucleus in the rat.

    abstract::The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90239-8

    authors: Stratford TR,Wirtshafter D

    更新日期:1990-03-12 00:00:00

  • Exogenous β-amyloid peptide interferes with GLUT4 localization in neurons.

    abstract::Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent: diabetes and Alzheimer's disease. Studies have shown that diabetes is a risk factor for spontaneous Alzheimer's disease. While these studies suggest that diabetes can contribut...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.04.026

    authors: Oliveira LT,Leon GVO,Provance DW Jr,de Mello FG,Sorenson MM,Salerno VP

    更新日期:2015-07-30 00:00:00

  • Effect of 4-aminopyridine on transmitter release in synaptosomes.

    abstract::The effect of 4-aminopyridine (4-AP) on the release of labeled transmitters in mouse brain synaptosomes was studied in a superfusion system. 4-AP at microM concentrations notably stimulated the spontaneous release of labeled GABA and glutamate, and of acetylcholine (ACh) derived from tritiated choline. No effects on t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90423-1

    authors: Tapia R,Sitges M

    更新日期:1982-11-04 00:00:00

  • Postnatal changes in the termination pattern of recurrent axon collaterals of triceps surae alpha-motoneurons in the cat.

    abstract::alpha-Motoneurons innervating the triceps surae and short plantar muscles were stained intracellularly with horseradish peroxidase (HRP) in 0-44-day-old kittens and adult cats. The terminal arborizations of the recurrent axon collaterals in the spinal cord were studied in the light microscope (LM). The short plantar m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90132-4

    authors: Cullheim S,Ulfhak B

    更新日期:1985-01-01 00:00:00

  • Involvement of calmodulin-dependent protein kinase II in carbachol-induced rhythmic activity in the hippocampus of the rat.

    abstract::The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretrea...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02331-3

    authors: Alberi S,Boeijinga PH,Raggenbass M,Boddeke HW

    更新日期:2000-07-28 00:00:00

  • Supporting evidence for negative modulation by protons of an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain using ligand binding techniques.

    abstract::The addition of L-glutamic acid (Glu) alone, both Glu and glycine (Gly) or Glu/Gly/spermidine (SPD) was effective in potentiating [3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding before equilibrium to an ion channel associated with the N-methyl-D-aspartate (NMDA) receptor complex in b...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91029-4

    authors: Yoneda Y,Enomoto R,Ogita K

    更新日期:1994-02-14 00:00:00

  • Neural correlates of successful memory retrieval in aging: Do executive functioning and task difficulty matter?

    abstract::The current experiment aimed to explore age differences in brain activity associated with successful memory retrieval in older adults with different levels of executive functioning, at different levels of task demand. Memory performance and fMRI activity during a recognition task were compared between a young group an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.10.009

    authors: Angel L,Bastin C,Genon S,Salmon E,Fay S,Balteau E,Maquet P,Luxen A,Isingrini M,Collette F

    更新日期:2016-01-15 00:00:00

  • Hydrogen peroxide as a source of molecular oxygen for in vitro mammalian CNS preparations.

    abstract::Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90280-9

    authors: Walton K,Fulton B

    更新日期:1983-11-14 00:00:00

  • Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.

    abstract::Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146760

    authors: Jung S,Ballheimer YE,Brackmann F,Zoglauer D,Geppert CI,Hartmann A,Trollmann R

    更新日期:2020-05-15 00:00:00

  • Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells.

    abstract::Transplantation of mesenchymal stem cells (MSCs) prepared from adult bone marrow (BMSCs) has been reported to ameliorate functional deficits in several CNS diseases in experimental animal models. Bone marrow was enriched in MSCs by selecting for plastic-adherent cells that were grown to confluency in appropriate cultu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.044

    authors: Kim S,Honmou O,Kato K,Nonaka T,Houkin K,Hamada H,Kocsis JD

    更新日期:2006-12-06 00:00:00

  • Unit activity alterations induced in the mesencephalic periaqueductal gray by local electrical stimulation.

    abstract::In the framework of a series of investigations concerning the neural substrate of aversion, electrophysiological methods were used in order to specify, within the rat's periaqueductal gray (PAG), functional properties, viz. conduction velocity and refractory period, of PAG neurons already assessed in previous studies ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90140-x

    authors: Sandner G,Schmitt P,Karli P

    更新日期:1986-10-29 00:00:00

  • Deferoxamine improves spatial memory performance following experimental brain injury in rats.

    abstract::Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01500-0

    authors: Long DA,Ghosh K,Moore AN,Dixon CE,Dash PK

    更新日期:1996-04-22 00:00:00

  • Exploring and targeting saccades dissociated by saccadic adaptation.

    abstract::Saccadic adaptation maintains saccade accuracy and has been studied with targeting saccades, i.e. saccades that bring the gaze to a target, with the classical intra-saccadic step procedure in which the target systematically jumps to a new position during saccade execution. Post-saccadic visual feedback about the error...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.07.029

    authors: Lavergne L,Vergilino-Perez D,Lemoine C,Collins T,Doré-Mazars K

    更新日期:2011-09-30 00:00:00

  • The effects of GABA and benzodiazepines on neurones in the suprachiasmatic nucleus (SCN) of Syrian hamsters.

    abstract::Administration of benzodiazepines at appropriate times in the circadian cycle induce phase-shifts in circadian locomotor activity. The possibility that benzodiazepine-induced shifts are mediated at the level of the suprachiasmatic nuclei (SCN), identified as the circadian pacemaker in mammals, was examined electrophys...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90659-j

    authors: Mason R,Biello SM,Harrington ME

    更新日期:1991-06-21 00:00:00

  • Differential response of hippocampal and prefrontal oscillations to systemic LPS application.

    abstract::The early electrophysiological phenomena linked to systemic inflammation are largely underexplored. We developed here local field analyses to detect prodromal oscillatory abnormalities. We identified early band-specific patterns in local field potential recorded from freely-moving rats injected intraperitoneally with ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.12.036

    authors: Mamad O,Islam MN,Cunningham C,Tsanov M

    更新日期:2018-02-15 00:00:00

  • The development and restriction of the ipsilateral retinofugal projection in the chick.

    abstract::Although it is generally believed that the central projections of the retina in birds are entirely crossed, using wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) as an anterograde tracer, we have found that in normal posthatched chicks there is a small ipsilateral retinofugal projection to the dience...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(83)90124-4

    authors: O'Leary DM,Gerfen CR,Cowan WM

    更新日期:1983-10-01 00:00:00

  • Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study.

    abstract::Although cocaine shares the ability of fenfluramine to inhibit the synaptic reuptake of serotonin, previous observations from our group suggest that the genomic effects of fenfluramine in the rat striatum are primarily mediated by dopaminergic rather than serotonergic mechanisms. To compare and further understand the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91391-9

    authors: Torres G,Rivier C

    更新日期:1994-05-30 00:00:00

  • NMDA receptor-mediated excitotoxicity contributes to the cerebral hypoxic injury of a rat model of posthypoxic myoclonus.

    abstract::Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days signi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.11.076

    authors: Tai KK,Truong DD

    更新日期:2007-02-16 00:00:00

  • Parvalbumin-positive projection neurons characterise the vocal premotor pathway in male, but not female, zebra finches.

    abstract::Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02938-9

    authors: Wild JM,Williams MN,Suthers RA

    更新日期:2001-11-02 00:00:00

  • Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats.

    abstract::Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A li...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147007

    authors: Marques MS,Cordeiro MF,Marinho MAG,Vian CO,Vaz GR,Alves BS,Jardim RD,Hort MA,Dora CL,Horn AP

    更新日期:2020-11-01 00:00:00

  • Calcitonin gene-related peptide projection from the ventromedial thalamic nucleus to the insular cortex: a combined retrograde transport and immunocytochemical study.

    abstract::We employed a highly sensitive combination method of retrograde tracing and immunohistochemistry to identify calcitonin gene-related peptide (CGRP)-containing fiber pathways in the rat from the ventrolateral part of the ventrolateral thalamic nucleus (vl-vl) and the caudal continuation to the insular cortex. Biotin-wh...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91211-9

    authors: Shimada S,Shiosaka S,Hillyard CJ,Girgis SI,MacIntyre I,Emson PC,Tohyama M

    更新日期:1985-09-30 00:00:00

  • Three-dimensional morphology and distribution of pallidal axons projecting to both the lateral region of the thalamus and the central complex in primates.

    abstract::This study presents a three-dimensional analysis of pallido-thalamic axons and axonal endings in the monkey (Macaca mulatta and M. irus). Injections of the anterograde tracer biocytin were made in the dorsal, associative region of the medial pallidum. Numerous axonal endings were observed within the pallidal territory...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00181-9

    authors: Arecchi-Bouchhioua P,Yelnik J,François C,Percheron G,Tandé D

    更新日期:1997-04-18 00:00:00

  • Chemosensitivity of non-respiratory rat CNS neurons in tissue culture.

    abstract::Neurons from many brainstem nuclei involved in respiratory control increase their firing rate in response to acidosis in vitro, suggesting that they are central chemoreceptors. This property has been considered to be either unique to neurons involved in respiratory control, or at least very unusual for non-respiratory...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02033-3

    authors: Wang W,Richerson GB

    更新日期:2000-03-31 00:00:00

  • Glutamatergic antagonists do not attenuate light-induced fos protein in rat intergeniculate leaflet.

    abstract::Photic information that entrains circadian rhythms is transmitted to the suprachiasmatic nucleus (SCN) from the retina and from the retinorecipient intergeniculate leaflet (IGL). Expression of light-induced Fos protein in SCN neurons is correlated with the effectiveness of such light to induce phase shifts, and is pre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00911-1

    authors: Edelstein K,Amir S

    更新日期:1998-11-09 00:00:00

  • Functional neuroanatomy of visual search with differential attentional demands: an fMRI study.

    abstract::Visual search is characterized as efficient (RT independent of distractor number) or inefficient (RT increasing with distractor number). Our goal was to determine if any brain regions are differentially activated by the attentional demands of these two search modes. We used fMRI to examine activation patterns during s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.07.004

    authors: Kim KK,Eliassen JC,Lee SK,Kang E

    更新日期:2012-09-26 00:00:00