Glycine-like immunoreactivity in synaptic boutons of identified inhibitory interneurons in the mammalian spinal cord.

Abstract:

:Glycine is thought to be a major inhibitory neurotransmitter in the mammalian CNS. Two types of physiologically identified interneurons, Renshaw cells and Ia inhibitory interneurons, were intracellularly stained with horseradish peroxidase, and their axon terminals were studied at the electron microscopic level. Post-embedding immunogold procedures were used to reveal the presence of glycine-like immunoreactivity. The synaptic terminals of both types of interneuron were significantly enriched with glycine-like immunoreactivity, providing support for the idea that glycine is a mediator of synaptic transmission in the recurrent and reciprocal inhibitory pathways to motoneurons.

journal_name

Brain Res

journal_title

Brain research

authors

Fyffe RE

doi

10.1016/0006-8993(91)90590-r

subject

Has Abstract

pub_date

1991-04-26 00:00:00

pages

175-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)90590-R

journal_volume

547

pub_type

杂志文章
  • Central catecholamine metabolism and hypothalamic self-stimulation behaviour in two inbred strains of mice.

    abstract::These experiments were conducted in order to better understand the role of catecholaminergic neurons in intracranial self-stimulation behaviour (ICSS) elicited from the lateral hypothalamus (LH). Two strains of mice which differ in their ICSS rate and their thresholds were studied. In a first time, we compared the cat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90341-4

    authors: Garrigues AM,Cazala P

    更新日期:1983-04-18 00:00:00

  • Identification and characterisation of two surface glycoproteins on cultured cerebellar cells.

    abstract::Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glyco...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)91197-x

    authors: Goridis C,Hirsch M,Dossetto M,Baechler E

    更新日期:1980-01-27 00:00:00

  • Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.

    abstract::Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet little is known r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.02.019

    authors: Liao G,Wen Z,Irizarry K,Huang Y,Mitsouras K,Darmani M,Leon T,Shi L,Bi X

    更新日期:2010-04-14 00:00:00

  • Rapid conversion of myelin-associated glycoprotein to a soluble derivative in primates.

    abstract::Myelin-associated glycoprotein (MAG) is susceptible to proteolysis by a calcium-activated neutral protease which is located in myelin. The conversion of MAG (M(r) 100,000) to its soluble derivative dMAG (M(r) 90,000) occurs much more rapidly in myelin from human white matter than in myelin from rat brain, and the rate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)00882-7

    authors: Möller JR

    更新日期:1996-11-25 00:00:00

  • Locomotor activity in the ischemic gerbil.

    abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91081-3

    authors: Babcock AM,Baker DA,Lovec R

    更新日期:1993-10-22 00:00:00

  • Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus.

    abstract::The family of EF-hand calcium binding proteins is composed of more than 250 members. In search for other neuronal markers, we studied the expression pattern of Necab-1, -2 and -3 in the Ammons horn of adult mice at the gene- and protein levels using in-situ hybridization and immunohistochemistry. The genes for the thr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.06.004

    authors: Zimmermann B,Girard F,Mészàr Z,Celio MR

    更新日期:2013-08-28 00:00:00

  • Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine.

    abstract::Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-D-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91202-c

    authors: Wolf ME,Khansa MR

    更新日期:1991-10-18 00:00:00

  • Amyloid beta modulation of neuronal network activity in vitro.

    abstract::In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.09.036

    authors: Charkhkar H,Meyyappan S,Matveeva E,Moll JR,McHail DG,Peixoto N,Cliff RO,Pancrazio JJ

    更新日期:2015-12-10 00:00:00

  • Studies on the encephalitogenic effects of purified preparations of human and bovine oligodendrocytes.

    abstract::Bulk-isolated human and bovine oligodendroglia, practically free from myelin, have been used in attempts to elicit an autoimmune response which has been compared with acute experimental allergic encephalomyelitis (EAE). For these experiments, a total of 20 Hartley guinea pigs, 33 Lewis rats and 16 rabbits have been st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90906-4

    authors: Raine CS,Wiśniewski HM,Iqbal K,Grundkeiqbal I,Norton WT

    更新日期:1977-01-21 00:00:00

  • Late onset of hearing in the ferret.

    abstract::Onset of hearing in the ferret was judged by simple behavioral, physiological and anatomical indices. The ear canals do not open until the end of the first postnatal month. This coincides with the appearance of a startle response to loud hand claps and the recording of acoustically activated neurons in the midbrain. T...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90698-9

    authors: Moore DR

    更新日期:1982-12-16 00:00:00

  • Inhibition from locus coeruleus of nucleus accumbens neurons activated by hippocampal stimulation.

    abstract::Electrophysiological studies using rats were performed to examine the influence of locus coeruleus (LC) on nucleus accumbens (Acc) neurons. Spike generation by hippocampal stimulation was inhibited by both LC conditioning stimulation and iontophoretic application of noradrenaline, but spikes elicited by stimulation of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90172-6

    authors: Unemoto H,Sasa M,Takaori S

    更新日期:1985-07-15 00:00:00

  • Do not think about pain: neural correlates of attention guiding during visual symptom provocation in dental phobia--an fMRI study.

    abstract::Patients undergoing dental treatment employ different attentional strategies. In order to investigate associated neuronal correlates, we exposed 20 women suffering from dental phobia and 20 non-anxious women to disorder-related and unrelated pictures. They were asked to either direct their attention to a foreground st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.04.017

    authors: Scharmüller W,Ubel S,Leutgeb V,Schoengassner F,Wabnegger A,Schienle A

    更新日期:2014-05-30 00:00:00

  • CNTF potentiates peripheral nerve regeneration.

    abstract::The effect of ciliary neurotrophic factor (CNTF) on peripheral nerve regeneration was studied in 6-week-old rats following sciatic nerve transection and juxtaposition of proximal and distal stumps. Rats received intraperitoneal recombinant human CNTF, 1 mg/kg every other day for 12 days. In all CNTF-treated animals, t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91621-7

    authors: Sahenk Z,Seharaseyon J,Mendell JR

    更新日期:1994-08-29 00:00:00

  • Protective effect of stellate ganglion block on delayed cerebral vasospasm in an experimental rat model of subarachnoid hemorrhage.

    abstract::Stellate ganglion block (SGB) is a blockade of sympathetic ganglia innervating the head and neck, and is known to function through vasodilation of the target region. However, the effectiveness of SGB in relieving cerebral vasospasm (CVS) through dilation of intracerebral vessels has not been evaluated. The aim of the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.08.012

    authors: Hu N,Wu Y,Chen BZ,Han JF,Zhou MT

    更新日期:2014-10-17 00:00:00

  • The collagenase model of intracerebral hemorrhage in awake, freely moving animals: The effects of isoflurane.

    abstract::Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146593

    authors: Wilkinson CM,Kalisvaart ACJ,Kung TFC,Maisey DR,Klahr AC,Dickson CT,Colbourne F

    更新日期:2020-02-01 00:00:00

  • Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity.

    abstract::NMDA receptor activation leads to elevated Ca2+ in cultured rat cortical and retinal ganglion cell neurons. If excessive, this Ca2+ response is associated with delayed neurotoxicity. We used dantrolene and ionomycin to test if the Ca2+ response to NMDA was due to mobilization of intracellular Ca2+ stores rather than m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90183-a

    authors: Lei SZ,Zhang D,Abele AE,Lipton SA

    更新日期:1992-12-11 00:00:00

  • Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons.

    abstract::We studied the effects of nitric oxide (NO) and the NO-releasing agents sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) and isosorbide dinitrate (ISDN) on N-methyl-D-aspartate (NMDA)-induced increases in intracellular Ca2+ ([Ca2+]i), whole-cell patch-clamp currents and on glutamate-stimulated [3H]di...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91690-g

    authors: Hoyt KR,Tang LH,Aizenman E,Reynolds IJ

    更新日期:1992-10-02 00:00:00

  • Ethanol-induced alterations of c-Fos immunoreactivity in specific limbic brain regions following ethanol discrimination training.

    abstract::The discriminative stimulus properties of ethanol are functionally regulated by ionotropic GABA(A) and NMDA receptors in specific limbic brain regions including the nucleus accumbens, amygdala, and hippocampus, as determined by microinjection studies. The purpose of the present work was to further investigate potentia...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.07.061

    authors: Besheer J,Schroeder JP,Stevenson RA,Hodge CW

    更新日期:2008-09-26 00:00:00

  • DIgLONs inhibit initiation of neurite outgrowth from forebrain neurons via an IgLON-containing receptor complex.

    abstract::IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.12.028

    authors: Akeel M,McNamee CJ,Youssef S,Moss D

    更新日期:2011-02-16 00:00:00

  • NMDA receptor blockade inhibits glutamate-induced kindling of the rat amygdala.

    abstract::Full limbic seizures were kindled in rats by repeated, bi-daily microinjections of glutamate (1.5 mumol) into the basolateral amygdala. Co-administration of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid with the glutamate, prevented the development of both electroencephalographi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91279-p

    authors: Croucher MJ,Bradford HF

    更新日期:1990-01-08 00:00:00

  • Suprachiasmatic nucleus: role in circannual body mass and hibernation rhythms of ground squirrels.

    abstract::Female golden-mantled ground squirrels that sustained complete ablation of the suprachiasmatic nucleus (SCNx) were housed pre- and post-operatively at 23 degrees C and then at 6.5 degrees C for 5-7 yr. SCNx and control animals held at the higher temperature manifested circannual rhythms (CARs) in body mass. In contras...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01263-8

    authors: Ruby NF,Dark J,Heller HC,Zucker I

    更新日期:1998-01-26 00:00:00

  • A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons.

    abstract::GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining tonic currents in a controlled environment of dissociated, solitary glut...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.033

    authors: Eisenman LN,Kress G,Zorumski CF,Mennerick S

    更新日期:2006-11-06 00:00:00

  • Catecholaminergic based therapies for functional recovery after TBI.

    abstract::Among the many pathophysiologic consequences of traumatic brain injury are changes in catecholamines, including dopamine, epinephrine, and norepinephrine. In the context of TBI, dopamine is the one most extensively studied, though some research exploring epinephrine and norepinephrine have also been published. The pur...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2015.12.026

    authors: Osier ND,Dixon CE

    更新日期:2016-06-01 00:00:00

  • Aggression-associated changes in murine olfactory tubercle bioamines.

    abstract::The relationship between changes in regional brain bioamine levels and the expression of intraspecies aggressive behavior was evaluated in two murine models. In one study, normal male mice were maintained either in aggregate (i.e., normal, intraspecies social behavioral controls) or isolated (i.e., developed, non-soci...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03963-x

    authors: Garris DR

    更新日期:2003-02-14 00:00:00

  • Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.

    abstract::Alzheimer's disease (AD) is one of the most common forms of dementia with still unknown pathogenesis. Several cytokines and chemokines are involved in the pathogenesis of AD. Among the chemokines, the CXCR4/CXCL12 complex has been shown to play an important role in the pathogenetic development of AD. We investigated t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147127

    authors: Sanfilippo C,Castrogiovanni P,Imbesi R,Nunnari G,Di Rosa M

    更新日期:2020-12-15 00:00:00

  • Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease.

    abstract::The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.05.048

    authors: Maida ME,Hurley SD,Daeschner JA,Moore AH,O'Banion MK

    更新日期:2006-08-04 00:00:00

  • The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins.

    abstract::The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five major functional systems, namely the dorsal somatomotor basal ganglia; ventral viscerolimbic basal...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2011.09.037

    authors: Kuenzel WJ,Medina L,Csillag A,Perkel DJ,Reiner A

    更新日期:2011-11-18 00:00:00

  • Effects of training on saccadic eye movements elicited electrically from the frontal cortex of monkeys.

    abstract::It has been reported that training affects motor responses evoked electrically from the dorsomedial frontal cortex (DMFC). Once a monkey had been trained to generate visually-guided saccadic eye movements of a particular size and direction, electrical stimulation of the DMFC elicited saccades of only that size and dir...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02663-9

    authors: Tehovnik EJ,Slocum WM

    更新日期:2000-09-15 00:00:00

  • Sex hormone binding globulin facilitates female sexual receptivity except when coupled to dihydrotestosterone.

    abstract::Sex hormone binding globulin (SHBG) is produced in brain where it is often co-localized with oxytocin. Infusions of SHBG into the medial preoptic area-anterior hypothalamus facilitate female sexual receptivity. SHBG has receptors on plasma membranes of the prostate gland where binding of the 5alpha-reduced androgen di...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02956-6

    authors: Caldwell JD,Höfle S,Englöf I

    更新日期:2002-09-06 00:00:00

  • Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease.

    abstract::Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.10.066

    authors: Kishimoto Y,Higashihara E,Fukuta A,Nagao A,Kirino Y

    更新日期:2013-01-23 00:00:00