Locomotor activity in the ischemic gerbil.

Abstract:

:Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenged this notion by testing ischemic gerbils at a time when increased activity is not observed with repeated testing. Ischemic (5-min bilateral carotid occlusion) and sham gerbils were tested for 14 consecutive days after reperfusion in an open-field apparatus (n = 6/condition). As previously reported, ischemic gerbils exhibited a significant increase in activity (days 1 and 2) which returned to control levels with repeated testing (days 13 and 14). A second group of ischemic and sham gerbils (n = 6/condition) were tested only on days 13 and 14 after reperfusion. In contrast to those tested repeatedly, these ischemic gerbils displayed increased locomotor activity as compared with sham controls. In addition, gerbils in the repeated testing conditions were evaluated in a semi-novel testing environment on days 15 and 16 after surgery. The locomotor activity of ischemic gerbils significantly increased in response to the semi-novel environment. These results suggest that the effects of ischemia on locomotor activity are not limited to a brief period after occlusion and may represent a permanent deficit. In addition, as previously suggested, this behavior may represent a deficit in habituation or spatial mapping rather than motor hyperactivity.

journal_name

Brain Res

journal_title

Brain research

authors

Babcock AM,Baker DA,Lovec R

doi

10.1016/0006-8993(93)91081-3

subject

Has Abstract

pub_date

1993-10-22 00:00:00

pages

351-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)91081-3

journal_volume

625

pub_type

杂志文章
  • Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma.

    abstract::Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91560-1

    authors: Popovich PG,Reinhard JF Jr,Flanagan EM,Stokes BT

    更新日期:1994-01-07 00:00:00

  • Conditioned taste aversion and latent inhibition following extensive taste preexposure in rats with insular cortex lesions.

    abstract::Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.12.058

    authors: Roman C,Lin JY,Reilly S

    更新日期:2009-03-09 00:00:00

  • The vestibulo ocular reflex (VOR) in otoconia deficient head tilt (het) mutant mice versus wild type C57BL/6 mice.

    abstract::The horizontal and vertical vestibulo ocular reflex (VOR) of head tilted (het) mutant mice was compared to C57BL/6 controls. Eye movements were recorded in darkness using a temporarily attached search coil. Contributions of semicircular canal versus otolith organ signals were investigated by providing a canal only (ve...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02505-8

    authors: Harrod CG,Baker JF

    更新日期:2003-05-16 00:00:00

  • Differential effects of inorganic lead on hippocampal long-term potentiation in young rats in vivo.

    abstract::Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02657-3

    authors: Zaiser AE,Miletic V

    更新日期:2000-09-08 00:00:00

  • Spatiotemporal patterns of the astroglial proliferation in rat brain injured at the postmitotic stage of postnatal development: a combined immunocytochemical and autoradiographic study.

    abstract::Proliferative response of astrocytes to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats using a combination of [3H]thymidine autoradiography and immunocytochemical staining for glial fibrillary acidic protein. At different intervals following injury the animals were injected with [3H]t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90566-0

    authors: Janeczko K

    更新日期:1989-04-24 00:00:00

  • Neuronal network properties of human teratocarcinoma cell line-derived neurons.

    abstract::Understanding the structural and functional development of neurons in networks has a high impact to estimate the potentials for restorative therapies. Neurons derived from the human NT2 cell line (hNT) formed networks with a clustered neuritic architecture in vitro, whereas primary dissociated embryonic rat cortical n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.05.076

    authors: Görtz P,Fleischer W,Rosenbaum C,Otto F,Siebler M

    更新日期:2004-08-20 00:00:00

  • Different myelination of rat septohippocampal fibres as revealed by immunofluorescence double-labelling.

    abstract::The present study focuses on the myelination of rat septohippocampal fibres that are known to originate from GABAergic parvalbumin-containing, fast-firing, fast-conducting neurons and from cholinergic slow-firing, slow-conducting neurons. With the combined immunofluorescence for parvalbumin/myelin basic protein and ch...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02653-6

    authors: Brauer K,Härtig W,Gärtner U,Brückner G,Arendt T

    更新日期:2000-09-29 00:00:00

  • REMOVED: Ion changes and signalling in perisynaptic glia.

    abstract::This article has been removed, consistent with Elsevier Policy on Article Withdrawal. Please see (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.10.003

    authors: Deitmer JW,Rose CR

    更新日期:2009-10-14 00:00:00

  • Brain injury improves survival of mice following brain ischemia.

    abstract::Minor brain injury was inflicted with a small needle at 4 sites one week before the production of incomplete brain ischemia in the mouse. A bilateral carotid clamp was applied for 60 min under pentobarbital anesthesia, and the number of survivors at one week after the ischemic insult was compared with those in animals...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90091-0

    authors: Takahata Y,Shimoji K

    更新日期:1986-09-03 00:00:00

  • Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons.

    abstract::Inflammation probably plays a significant role in perinatal brain injury. To study the contribution of locally produced cytokines, the effect on cell death of addition of IL-8 and MCP-1 or antibodies to these, and the impact of acidosis, human postmitotic NT2-N neurons were exposed to 3 h of hypoxia and glucose depriv...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.07.051

    authors: Frøyland E,Pedersen ED,Kvissel AK,Almaas R,Pharo A,Skålhegg BS,Mollnes TE,Rootwelt T

    更新日期:2006-10-03 00:00:00

  • Relative contribution of brain and peripheral connections to postnatal growth and cell accretion in the rat olfactory bulb.

    abstract::Total weight and DNA (cell number) determination in whole olfactory bulbs (OB) revealed that unilateral transection of the olfactory peduncle in newborn rats causes 2 X more (40%) deficit in cell number in the operated OB than section of the olfactory nerve. The deficit due to combined operations ('isolation' of OB) w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(86)90104-5

    authors: Meisami E,Hamedi S

    更新日期:1986-10-01 00:00:00

  • Phosphatidylcholine protects neurons from toxic effects of amyloid β-protein in culture.

    abstract::Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.04.035

    authors: Ko M,Hattori T,Abdullah M,Gong JS,Yamane T,Michikawa M

    更新日期:2016-07-01 00:00:00

  • Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain.

    abstract::The function of the phosphoinositide signal transduction system and the levels of heterotrimeric G-protein alpha-subunits were examined in postmortem prefrontal cortex regions (8/9) and region (10) from suicide victims with major depression and matched control subjects without psychiatric illness. The hydrolysis of [3...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00207-7

    authors: Pacheco MA,Stockmeier C,Meltzer HY,Overholser JC,Dilley GE,Jope RS

    更新日期:1996-06-03 00:00:00

  • Temporal and anatomical considerations involved in the effects of amygdaloid lesions on prolactin secretion in ovariectomized estrogenized rats.

    abstract::Plasma prolactin (PRL) levels were investigated in chronically catheterized control, sham-lesioned, and amygdala (AMYG)-lesioned rats under a variety of conditions. Ovariectomized (OVX) rats injected with 0.5 mg of polyestradiol phosphate (PEP) exhibited a circadian rhythm of PRL secretion characteristic of proestrus ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90202-4

    authors: Peters JA,Gala RR

    更新日期:1980-04-14 00:00:00

  • Evidence for the role of nitric oxide in kappa-opiate tolerance in mice.

    abstract::The hypothesis that inhibition of nitric oxide (NO) synthase with subsequent decrease in the production of NO might attenuate the development of kappa-opiate tolerance was examined. Concurrent treatment of NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) (2-8 mg/kg, i.p.) along with U-50,488H (25 mg/kg, i.p.) ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90316-f

    authors: Thorat SN,Reddy PL,Bhargava HN

    更新日期:1993-09-03 00:00:00

  • A distinctive soma size gradient among catecholaminergic neurones of human retinae.

    abstract::We have examined the soma diameters and distribution of catecholaminergic (CA) cells in human retinae, by using an antibody to tyrosine hydroxylase (TH), the rate limiting enzyme in the production of catecholamines. TH-immunoreactivity was detected in two classes of cells (CA1 and CA2 cells). CA1 cells had relatively ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91061-k

    authors: Mitrofanis J,Provis JM

    更新日期:1990-09-10 00:00:00

  • Effects of chloride flux modulators in an in vitro model of brain edema formation.

    abstract::Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.012

    authors: Kumar V,Naik RS,Hillert M,Klein J

    更新日期:2006-11-29 00:00:00

  • Neurotoxic lesions centered on the perifornical hypothalamus abolish the cardiovascular and behavioral responses of conditioned fear to context but not of restraint.

    abstract::The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.10.058

    authors: Furlong T,Carrive P

    更新日期:2007-01-12 00:00:00

  • Cardiovascular responses to L-glutamate microinjection into the hypothalamic paraventricular nucleus are mediated by a local nitric oxide-guanylate cyclase mechanism.

    abstract::It has been reported that L-glutamate (L-glu) microinjection into the hypothalamic paraventricular nucleus (PVN) evokes pressor and tachycardiac responses in unanesthetized rats. In the present study the hypothesis was tested that a local nitric oxide (NO)-guanylate cyclase interaction mediates cardiovascular effects ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.023

    authors: Busnardo C,Crestani CC,Tavares RF,Resstel LB,Correa FM

    更新日期:2010-07-16 00:00:00

  • Basic fibroblast growth factor increases cortical blood flow in vivo.

    abstract::Basic FGF has recently been shown to produce systemic and cerebral vasodilation. To test the hypothesis that bFGF increases regional cortical blood flow (rCBF), rCBF and brain pHi were measured while bFGF or vehicle was superperfused onto the cortex of rabbits. The results of this study demonstrate that topical applic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91167-3

    authors: Regli L,Anderson RE,Meyer FB

    更新日期:1994-11-28 00:00:00

  • Plectin immunopositivity appears in the astrocytes in the white matter but not in the gray matter after stab wounds.

    abstract::Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02399-9

    authors: Kálmán M,Szabó A

    更新日期:2000-02-28 00:00:00

  • Decreased cocaine- and lidocaine-induced seizure response by dextromethorphan and DNQX in rat.

    abstract::The present study investigated the effect of dextromethorphan and 6,7-dinitroquinoxaline-2,3-dione (DNQX) pre-treatment on the development of cocaine- and lidocaine-induced seizures. The dopaminergic action of cocaine was also studied. The NMDA antagonist dextromethorphan and the non-NMDA (AMPA/kainate) antagonist DNQ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00147-9

    authors: Barat SA,Abdel-Rahman MS

    更新日期:1997-05-09 00:00:00

  • Sleep deprivation differentially alters the mRNA and protein levels of neurogranin in rat brain.

    abstract::The mRNA level of the 17-kDa protein neurogranin (NG), a postsynaptic substrate of the protein kinase C, has previously been found to be decreased in rat forebrain after 24-h sleep deprivation (SD). To investigate the functional significance of this finding in various forebrain regions, the effect of 24-h SD on the mR...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00416-n

    authors: Neuner-Jehle M,Rhyner TA,Borbély AA

    更新日期:1995-07-10 00:00:00

  • Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats.

    abstract::The neurosteroid allopregnanolone is a potent and efficacious modulator of gamma-aminobutyric acid (GABA) type A receptors. The effects of intracerebroventricular injection of allopregnanolone (5 to 15 micrograms/5 microliters) on basal and stress-induced release of acetylcholine were investigated in various regions o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01478-0

    authors: Dazzi L,Sanna A,Cagetti E,Concas A,Biggio G

    更新日期:1996-02-26 00:00:00

  • Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress.

    abstract::Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.02.002

    authors: Duncan GE,Inada K,Farrington JS,Koller BH,Moy SS

    更新日期:2009-04-10 00:00:00

  • Melatonin attenuates neuronal NADPH-d/NOS expression in the hypoglossal nucleus of adult rats following peripheral nerve injury.

    abstract::Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02489-6

    authors: Chang HM,Ling EA,Lue JH,Wen CY,Shieh JY

    更新日期:2000-08-11 00:00:00

  • Vasopressinergic modulation of stress responses in the central amygdala of the Roman high-avoidance and low-avoidance rat.

    abstract::The central nucleus of the amygdala (CEA) is selectively involved in the passive component of the behavioral (immobility) and the accompanying parasympathetic response during conditioned, stressful environmental challenges. Vasopressinergic mechanisms in the brain seem to play a role in these stress responses. The eff...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91529-n

    authors: Roozendaal B,Wiersma A,Driscoll P,Koolhaas JM,Bohus B

    更新日期:1992-11-20 00:00:00

  • Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat.

    abstract::Intraperitoneal (i.p.) administration of sulfated CCK octapeptide (CCK-8S) has been shown to induce changes in neuronal activity in the nucleus of the solitary tract (NTS) and area postrema (AP), sensory parts of the dorsal vagal complex (DVC), and in the paraventricular nucleus of the hypothalamus (PVN), as determine...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00865-2

    authors: Mönnikes H,Lauer G,Arnold R

    更新日期:1997-10-03 00:00:00

  • Tectal transplants into the occipital cortex of the newborn rat.

    abstract::Embryonic day 15 rostral tectum (presumptive superior colliculus) was transplanted into the occipital cortex of newborn rats. One to two months later, the transplants were visualized and injected with either horseradish peroxidase (HRP) or wheat germ agglutinin conjugated with HRP (WGA/HRP). After the appropriate surv...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90088-5

    authors: Sharkey MA,Steedman JG,Lund RD,Dom RM

    更新日期:1987-01-01 00:00:00

  • Favored patterns in spontaneous spike trains.

    abstract::By using the modified detection method, favored patterns can be detected in a total of 44 spontaneous spike trains. Among these the 'periodical burst' discharge of one sympathetic preganglionic neuron and the 'fast-slow' alternative discharge of some hypothalamic neurons have visible characteristics, hence we use them...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90008-j

    authors: Ku YH,Wang XQ

    更新日期:1991-09-20 00:00:00