Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus.

Abstract:

:The family of EF-hand calcium binding proteins is composed of more than 250 members. In search for other neuronal markers, we studied the expression pattern of Necab-1, -2 and -3 in the Ammons horn of adult mice at the gene- and protein levels using in-situ hybridization and immunohistochemistry. The genes for the three Necab's were expressed in specific, non-overlapping areas of the hippocampus. A minority of the Necab-positive interneurons were GABA-ergic, and they virtually never coexpressed one of the classical calcium binding proteins (calretinin, calbindin D-28k and parvalbumin). Necab's are promising new neuronal markers in the brain.

journal_name

Brain Res

journal_title

Brain research

authors

Zimmermann B,Girard F,Mészàr Z,Celio MR

doi

10.1016/j.brainres.2013.06.004

subject

Has Abstract

pub_date

2013-08-28 00:00:00

pages

1-7

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(13)00832-9

journal_volume

1528

pub_type

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