CNTF potentiates peripheral nerve regeneration.


:The effect of ciliary neurotrophic factor (CNTF) on peripheral nerve regeneration was studied in 6-week-old rats following sciatic nerve transection and juxtaposition of proximal and distal stumps. Rats received intraperitoneal recombinant human CNTF, 1 mg/kg every other day for 12 days. In all CNTF-treated animals, the distribution of the anterograde transport of [3H]leucine-labeled material within the distal stump showed a distinct peak activity 21-24 mm distal to the nerve transection site. In contrast, the radioactivity in control nerves declined rapidly, distributed as proximodistal gradient without a distinct peak. In addition, the amount of radioactivity returning from the growing axon tips in CNTF was significantly greater than controls. The correlative morphologic studies showed a well-advanced stage of myelination in regenerating axons in CNTF compared to controls. These combined in vivo correlative kinetic and morphological studies indicate that CNTF dramatically potentiates axonal regeneration by promoting a greater number of elongating axon tips into the distal stump.


Brain Res


Brain research


Sahenk Z,Seharaseyon J,Mendell JR




Has Abstract


1994-08-29 00:00:00














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    abstract::The postnasal development of the Na-independent [3H]glutamate binding sites, which exhibit some characteristics of postsynaptic glutamate receptors, has been studied in rat hippocampal membranes. The amount of binding sites (expressed in pmol/hippocampus) represents 4% of the adult level at postnatal day (PND) 4, incr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baudry M,Arst D,Oliver M,Lynch G

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  • Maternal exposure to delta9-tetrahydrocannabinol facilitates morphine self-administration behavior and changes regional binding to central mu opioid receptors in adult offspring female rats.

    abstract::Opiates and cannabinoids are among the most widely consumed habit-forming drugs in humans. Several studies have demonstrated the existence of interactions between both kind of drugs in a variety of effects and experimental models. The present study has been focused to determine whether perinatal delta9-tetrahydrocanna...

    journal_title:Brain research

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    authors: Vela G,Martín S,García-Gil L,Crespo JA,Ruiz-Gayo M,Fernández-Ruiz JJ,García-Lecumberri C,Pélaprat D,Fuentes JA,Ramos JA,Ambrosio E

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  • Inhibiting carbonic anhydrase in brain tissue increases the respiratory response to rebreathing CO2.

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    journal_title:Brain research

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    authors: Adams JM,Johnson NL

    更新日期:1990-06-11 00:00:00

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    journal_title:Brain research

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    authors: Noguchi T,Sugisaki T,Kudo M,Satoh I

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  • Inhibition from locus coeruleus of nucleus accumbens neurons activated by hippocampal stimulation.

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    journal_title:Brain research

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    authors: Unemoto H,Sasa M,Takaori S

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    authors: Koenig J,Mayfield MA,Coppings RJ,McCann SM,Krulich L

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    authors: Libri V,Ammassari-Teule M,Castellano C

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  • Parasympathetic varicosity proliferation and synaptogenesis in rat eyelid smooth muscle after sympathectomy.

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    journal_title:Brain research

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    journal_title:Brain research

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    authors: Emson PC,Joseph MH

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    journal_title:Brain research

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    authors: Shibasaki T,Oda T,Imaki T,Ling N,Demura H

    更新日期:1993-01-22 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pinault D

    更新日期:1992-03-27 00:00:00

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    journal_title:Brain research

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    authors: Han ZS,Gu GB,Sun CQ,Ju G

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    journal_title:Brain research

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    authors: Szymusiak R,McGinty D,Fairchild MD,Jenden DJ

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  • Extracellular cholecystokinin levels in the rat spinal cord following chronic morphine exposure: an in vivo microdialysis study.

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    journal_title:Brain research

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    authors: Lucas GA,Hoffmann O,Alster P,Wiesenfeld-Hallin Z

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    authors: Wang P,Lu Y,Han D,Wang P,Ren L,Bi J,Liang J

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    journal_title:Brain research

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bales KL,Mason WA,Catana C,Cherry SR,Mendoza SP

    更新日期:2007-12-12 00:00:00

  • A LANT6-like substance that is distinct from neuromedin N is present in pallidal and striatal neurons in monkeys.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Reiner A

    更新日期:1987-09-29 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Moon C,Ahn M,Wie MB,Kim HM,Koh CS,Hong SC,Kim MD,Tanuma N,Matsumoto Y,Shin T

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hassall CJ,Burnstock G

    更新日期:1987-09-29 00:00:00