Abstract:
:Endogenous hyperprolactinaemia was induced in intact male rats by transplantation of pituitaries under the kidney capsule. Five days later the utilization of noradrenaline (NA) and dopamine (DA) in individual brain nuclei and changes of plasma prolaction (PRL) were measured. Inhibition of catecholamine synthesis by alpha-methyl-p-tyrosine (alpha-MPT) was used to measure utilization. Hyperprolactinaemia increased the utilization of NA in the locus coeruleus, the cell-body region of the dorsal noradrenergic bundle (DNB), but decreased it in some terminal projections of the same pathway (e.g. the cingulate gyrus). DA utilization was increased by hyperprolactinaemia in the eminentia mediana. In the nigrostriatal DA-ergic projection, hyperprolactinaemia decreased the utilization of DA in the cell-body region (substantia nigra) and increased it in the terminal projection (nucleus caudatus). In the ventral tegmental area (mesolimbic DA-ergic projection), hyperprolactinaemia decreased the utilization of DA. It is concluded that hyperprolactinaemia affects neurotransmission in the hypothalamus and also in specific extrahypothalamic pathways (e.g. DNB, nigrostriatal and mesolimbic DA-ergic projections) and that these changes may correlate with some behavioural effects of the pituitary hormone.
journal_name
Brain Resjournal_title
Brain researchauthors
Kovács GL,Drago F,Acsai L,Tihanyi A,Scapagnini U,Telegdy Gdoi
10.1016/0006-8993(84)90618-8subject
Has Abstractpub_date
1984-12-17 00:00:00pages
29-34issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90618-8journal_volume
324pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::There have been few reports concerning facilitation and depression in sympathetic ganglia9,17,40. In the present investigation, pairs of excitatory postsynaptic potentials (EPSPs) were recorded intracellularly from bullfrog paravertebral sympathetic ganglia for an analysis of the site and mechanism responsible for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90840-4
更新日期:1976-12-10 00:00:00
abstract::Recent findings have shown that systemic morphine increases extracellular dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ascorbic acid (AA) and uric acid concentrations in the striatum of freely moving rats. The morphine-induced increase in DA oxidative metabolism is highly correlated with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00371-0
更新日期:1998-06-22 00:00:00
abstract::One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90068-8
更新日期:1983-02-01 00:00:00
abstract::The same cells in both the intact retina and retinal cultures of the rabbit retina take up exogenous serotonin or 5,7-dihydroxytryptamine. Both substances can be localised by immunohistochemistry using a monoclonal antibody directed against serotonin. The 5,7-dihydroxytryptamine can also be revealed directly in both f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90125-3
更新日期:1986-09-10 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. In a transgenic mouse model of ALS (SOD1-G93A) weakness appears at 3 months of age, and because of progressive paralysis leads to death by 5 months. Cyclospo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02012-1
更新日期:2001-03-16 00:00:00
abstract::The functional organization of projections from the cerebellar subcortical nuclei to the motor cortex through the nucleus ventralis lateralis (VL) of the thalamus was studied using tungsten microelectrodes for stimulation and recordings in acute and chronic cats. The following results were obtained. (1) Microstimulati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90510-7
更新日期:1975-11-07 00:00:00
abstract::Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90773-0
更新日期:1994-12-15 00:00:00
abstract::Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.070
更新日期:2008-07-07 00:00:00
abstract::To study morphological changes in the cortex that follow repeated ischemia, one, two, and three 7-min unilateral occlusions of the carotid artery at 6-h intervals, and three, four, and five 7-min similar occlusions at 12-h intervals were produced in gerbils. Animals with one and two 7-min occlusions at 6-h intervals s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00449-z
更新日期:1995-07-17 00:00:00
abstract::The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90136-6
更新日期:1977-11-04 00:00:00
abstract::Purkinje cells are the sole output from the cerebellar cortex and play a critical role during classical eyeblink conditioning. The present study revealed for the first time a learning-related change in individual Purkinje cell activity during successive eyeblink conditioning in decerebrate guinea pigs which permitted ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.090
更新日期:2006-01-12 00:00:00
abstract::A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.014
更新日期:2007-12-05 00:00:00
abstract::The mechanism of action of norepinephrine (NE)-induced potentiation of the population spike in the dentate gyrus of hippocampal slices was examined and compared with NE effects in field CA1. NE-induced potentiation was confined to the dentate gyrus, where slices perfused for 30 min with concentrations of NE as low as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91299-5
更新日期:1985-12-30 00:00:00
abstract::Using site-specific antibodies, we assessed the effect of aggregation of various length forms of A beta on the immunoreactive profile of the peptides. All of the antibodies tested reacted with monomeric/dimeric forms of A beta 1-42 and its further aggregates. However, antibodies directed against the 1-24 region of A b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01195-1
更新日期:1995-12-12 00:00:00
abstract::Serotoninergic transmission is implicated in the photic and non-photic regulation of circadian rhythms. 5-HT (1-100 microM), carboxamidotryptamine (5-CT 0.1-10 microM) and (+)-8-hydroxy-dipropylaminotetraline (8-OH-DPAT, 1-30 microM) dose-dependently activated an outward current (5-100 pA) in 30% of neurons voltage-cl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02294-0
更新日期:2000-06-02 00:00:00
abstract::Early brain injury (EBI) refers to the direct injury to the brain during the first 72 h after subarachnoid hemorrhage (SAH), which is one of the major causes for the poor clinical outcome after SAH. In this study, we investigated the effect and the related mechanism of Salvinorin A (SA), a selective kappa opioid recep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.05.026
更新日期:2019-09-15 00:00:00
abstract::The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.084
更新日期:2004-05-08 00:00:00
abstract::The purpose of this study was to ascertain whether visual acuity or contrast sensitivity function (CSF) is proportional to visual cortical function based on fMRI volume and level of activation or Z-score. Forced choice procedures were utilized to measure the monocular log minimal angle of resolution (logMAR) visual ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.082
更新日期:2011-01-07 00:00:00
abstract::Type 2 iodothyronine deiodinase, an enzyme involved in the conversion of thyroxin to the biologically active 3,5, 3'-triiodothyronine, is highly concentrated in a group of specialized ependymal cells, tanycytes, lining the wall and floor of the third ventricle. As this distribution is highly reminiscent of the distrib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02105-3
更新日期:2000-04-17 00:00:00
abstract::Specific binding of [3H](+-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a highly selective antagonist for N-methyl-D-aspartic acid (NMDA) receptors, was examined in brain synaptic membranes treated with Triton X-100 by using a filtration assay method. Elevation of incubation temperature from 2 to 30 de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90575-v
更新日期:1990-05-07 00:00:00
abstract::Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90166-5
更新日期:1984-09-24 00:00:00
abstract::The outgrowth region of the regenerating frog sciatic nerve shows an increased permeability for various drugs, which has been utilized for pharmacological studies of axonal transport. Six days after a bilateral crush lesion, the nerves, including the spinal ganglia, were incubated in a compartmented chamber. Orthograd...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91160-7
更新日期:1987-01-13 00:00:00
abstract::The presence of thyrotropin-releasing-hormone-immunoreactive (TRH-ir) amacrine cells in the retina of amphibians is reported for the first time. The anuran and urodele retinas studied exhibit major differences in the distribution of TRH-ir cells. In the two urodele species investigated, most TRH-ir amacrine cells were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03307-8
更新日期:2002-02-01 00:00:00
abstract::The release of amino acids in the locus coeruleus (LC) of conscious, freely moving rats was studied in time periods of 3 min by use of push-pull superfusion under basal conditions and during application of various experimental stimuli known to influence the activity of the LC-noradrenergic system. Tail pinch for 3 min...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01102-1
更新日期:1995-12-15 00:00:00
abstract::Unilateral visual cortex ablations in neonatal rabbits produced no detectable loss of ganglion cells in the contralateral retina following a survival period of 3, 4 or 8 months. Analysis of neuron size distributions and neuron densities from whole-mounted retinas indicate that transneuronal retrograde degeneration doe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90218-4
更新日期:1985-08-01 00:00:00
abstract::An autoradiographic analysis of the time and sites of origin, and the migration and settling patterns of neurons was made in the spinal cord of the mouse. The neurons originated on days 10--14 of gestation with temporal gradients along the ventrodorsal and rostrocaudal axes. The motor neurons originated on days 10 and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90105-1
更新日期:1978-12-22 00:00:00
abstract::Cell cultures of olfactory bulb from 2-3-day-old rats were used to evaluate 6 antimitotic drugs for their effects on neuronal survival. In cultures grown in medium without drugs for 7 days, neurons died as a layer of non-neuronal cells proliferated. A series of experiments were performed to determine dilutions and exp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90629-7
更新日期:1983-02-21 00:00:00
abstract::Diffusion patterns of 14C-labeled penicillin, resulting from microinjections into different neocortical laminae, were compared with simultaneous electrophysiologic monitoring of epileptogenesis across these laminae. Injections into layer IV produced response alterations quickly in all recorded layers even with penicil...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90957-0
更新日期:1984-01-09 00:00:00
abstract::The present study was designed to assess the effect of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) on desensitization of Torpedo acetylcholine (ACh) receptors by analyzing summated macroscopic currents in an outside-out patch-clamp configuration. Normal ACh receptors desensitized with a fast (6 ms) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00836-1
更新日期:1998-11-23 00:00:00
abstract::The disector method was used to estimate the numerical density of neurons (number per unit volume) and their actual number per column (number under a given area of pial surface), in the occipital (monocular segment of the primary visual area, Oc1M), the parietal (somatosensory barrelfield area, Par1) and the frontal c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90884-p
更新日期:1993-04-23 00:00:00