Retrogradely transported nerve growth factor increases ornithine decarboxylase activity in rat superior cervical ganglia.

abstract：:Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...

journal_title：Brain research

authors： Anderzhanova E,Oja SS,Saransaari P,Albrecht J

更新日期：2003-07-11 00:00:00

abstract：:To examine whether the activation of brainstem neurons during ingestion is due to orosensory afferents or post-ingestive factors, neuronal activation in response to intraoral and intragastric infusions of taste stimuli was compared in the area postrema (AP), nucleus tractus solitarius (NTS) and parabrachial nucleus (P...

journal_title：Brain research

authors： Yamamoto T,Sawa K

更新日期：2000-06-02 00:00:00

abstract：:Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alpha-(2-sulfophenyl)nitrone) to reduce hydroxyl radical formation. Micr...

journal_title：Brain research

authors： Ferger B,Teismann P,Mierau J

更新日期：2000-11-17 00:00:00

abstract：:Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...

journal_title：Brain research

authors： Xie D,Croaker GDH,Li J,Song ZM

更新日期：2016-07-01 00:00:00

abstract：:Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...

journal_title：Brain research

authors： Reznikov LR,Reagan LP,Fadel JR

更新日期：2009-02-23 00:00:00

abstract：:Lesions to the ventromedial hypothalamus (VMH) inhibit receptive sexual behavior in the whiptail lizard, Cnemidophorus uniparens, an all-female species. All lesions to the VMH that effectively abolished receptivity specifically damaged the dorsal lateral VMH, an area containing high concentrations of estrogen receptor...

journal_title：Brain research

authors： Kendrick AM,Rand MS,Crews D

更新日期：1995-05-22 00:00:00

abstract：:We have previously demonstrated that Fos immunoreactivity can be stimulated by KCl, forskolin or glutamate in cultured tyrosine hydroxylase-immunoreactive (TH-ir) hypothalamic neurons. The present study was performed to determine whether agents that regulate dopaminergic activity, particularly D1 and D2 receptor agoni...

journal_title：Brain research

authors： Sim LJ,Selley DE,Tsai KP,Morris M

更新日期：1994-07-18 00:00:00

abstract：:In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities c...

journal_title：Brain research

authors： Takahashi O,Traub RJ,Ruda MA

更新日期：1988-12-13 00:00:00

abstract：:The effects of the imidazothienodiazepinone Ro 19-4603 were investigated in mice. Ro 19-4603 (0.03-0.3 mg/kg) caused a dose-related reduction in seizure threshold to i.v. bicuculline. Doses of 0.1-3 mg/kg induced seizures in some but not all mice, consistent with its suggested action as a partial benzodiazepine recept...

journal_title：Brain research

authors： Lister RG,Durcan MJ

更新日期：1989-03-13 00:00:00

abstract：:The presence of adrenocorticotropic hormone (ACTH)-immunoreactive cells and melanocortin (MC) receptors (MC4 and to a lesser extent MC3) has been demonstrated in the medullary reticular formation in the general area where rostral ventrolateral medullary pressor area (RVLM) is located. The importance of RVLM in the reg...

journal_title：Brain research

authors： Kawabe T,Chitravanshi VC,Kawabe K,Sapru HN

更新日期：2006-08-02 00:00:00

abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...

journal_title：Brain research

authors： Green KM,Linsalata AE,Todd PK

更新日期：2016-09-15 00:00:00

abstract：:The pedunculopontine nucleus (PPN) located in the mesopontine tegmentum is innervated by descending projections from nuclei in the basal ganglia. The present study was performed to determine whether nigrostriatal dopaminergic neuron degeneration is associated with changes in PPN metabolic activity. Unilateral nigrostr...

journal_title：Brain research

authors： Carlson JD,Pearlstein RD,Buchholz J,Iacono RP,Maeda G

更新日期：1999-05-15 00:00:00

abstract：:The effects of acetylcholine (ACh) and physostigmine (PHY) on thoracic ganglion neurons of Locusta migratoria were investigated using whole-cell and cell-attached voltage clamp. ACh activated whole-cell currents with variable amplitudes, time course and ion channel block between cells, suggesting differential expressi...

journal_title：Brain research

authors： van den Beukel I,van Kleef RG,Zwart R,Oortgiesen M

更新日期：1998-04-13 00:00:00

abstract：:Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...

journal_title：Brain research

authors： Kirby MT,Hampson RE,Deadwyler SA

更新日期：2000-04-28 00:00:00

abstract：:Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding for zif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acu...

journal_title：Brain research

authors： Wang JQ,McGinty JF

更新日期：1995-03-06 00:00:00

abstract：:The lactating rat has been shown to lack a behavioral response and immediate early gene expression (cFos) in the hippocampus (Hipc) following intravenous or intracerebroventricular administration of an N-methyl-d-aspartate (NMDA) receptor agonist. The purpose of this study is to determine whether neurons in the Hipc h...

journal_title：Brain research

authors： Grove KL,Smith MS

更新日期：1998-12-14 00:00:00

abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...

journal_title：Brain research

authors： Zhang Y,Shen GL,Shangguan LJ,Yu Y,He ML

更新日期：2015-05-22 00:00:00

abstract：:The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...

journal_title：Brain research

authors： Ikeuchi Y,Hirai H

更新日期：1994-11-21 00:00:00

abstract：:We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...

journal_title：Brain research

authors： Neal AP,Stansfield KH,Guilarte TR

更新日期：2012-02-23 00:00:00

abstract：:Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major compon...

journal_title：Brain research

authors： Razzaboni BL,Papastoitsis G,Koo EH,Abraham CR

更新日期：1992-09-04 00:00:00

abstract：:In tasks involving the learning of verbal or non-verbal sequences, groupings are spontaneously produced. These groupings are generally marked by a lengthening of final elements and have been attributed to a domain-general perceptual chunking linked to working memory. Yet, no study has shown how this domain-general chu...

journal_title：Brain research

authors： Gilbert AC,Boucher VJ,Jemel B

更新日期：2015-04-07 00:00:00

abstract：:Glycans are components of glycoconjugates and function in odorant recognition and cell signaling in the olfactory mucosa. However, little is known about glycan expression in the olfactory mucosa in the presence of neuroinflammatory disorders, which can influence olfaction. We evaluated the changes in glycan in the olf...

journal_title：Brain research

authors： Park C,Kim J,Ahn M,Choi Y,Shin T

更新日期：2020-04-01 00:00:00

abstract：:This report describes the relationship between monoamines, sleep and seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and two male). Concentrations (fmoles of norepinephrine or NE, dopamine or DA and serotonin or 5-HT) were quantified in consecutive, 5-min microdialysis s...

journal_title：Brain research

authors： Shouse MN,Staba RJ,Saquib SF,Farber PR

更新日期：2001-02-16 00:00:00

abstract：:Experiments were carried out on hippocampal slices from rats pretreated with a unilateral intraventricular injection of kainic acid. The kainic acid produced a lesion of the CA3 area in the hippocampus ipsilateral to the site of injection. The resulting neuroanatomically modified hippocampal slices allowed the indepen...

journal_title：Brain research

authors： Wheal HV,Lancaster B,Bliss TV

更新日期：1983-08-08 00:00:00

abstract：:Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive function, dementia, and problems with movements. In order to find new protein biomarkers of high specificity from cerebrospinal fluid (CSF) of AD and PD patients, one-dimensiona...

journal_title：Brain research

authors： Yin GN,Lee HW,Cho JY,Suk K

更新日期：2009-04-10 00:00:00

abstract：:A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the in...

journal_title：Brain research

authors： Preziosi P,Cerrito F,Vacca M

更新日期：1983-07-25 00:00:00

abstract：:We examined whether plasma epinephrine contributes to the increase in regional cerebral blood flow (rCBF) evoked by electrical stimulation of the dorsal medullary reticular formation (DMRF). Rats were anesthetized (alpha-chloralose, 30 mg/kg, s.c.), paralyzed and artificially ventilated. The DMRF was electrically stim...

journal_title：Brain research

authors： Lacombe PM,Iadecola C,Underwood MD,Sved AF,Reis DJ

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent foca...

journal_title：Brain research

authors： Pfefferkorn T,Wiessner C,Allegrini PR,Staufer B,Vosko MR,Liebetrau M,Bueltemeier G,Kloss CU,Hamann GF

更新日期：2000-11-03 00:00:00

abstract：:Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...

journal_title：Brain research

authors： Jung S,Ballheimer YE,Brackmann F,Zoglauer D,Geppert CI,Hartmann A,Trollmann R

更新日期：2020-05-15 00:00:00

abstract：:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

journal_title：Brain research

authors： Hoffman WE,Albrecht RF,Miletich DJ

更新日期：1981-06-09 00:00:00