Abstract：
:This report describes the relationship between monoamines, sleep and seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and two male). Concentrations (fmoles of norepinephrine or NE, dopamine or DA and serotonin or 5-HT) were quantified in consecutive, 5-min microdialysis samples (2 microl/min infusion rate) from amygdala and locus ceruleus complex (LC) during four, 6-8-h polygraphic recordings before (n=2) and 1 month post-kindling (n=2); 5-min recording epochs were temporally adjusted to correspond to dialysate samples and differentiated according to dominant sleep or waking state (lasting > or =80% of 5-min epoch) and degree of spontaneous seizure activity (number and duration of focal versus generalized spikes and spike trains and behavioral seizure correlates). Post-kindling records in each cat were divided into two groups (n=1 record each) based on higher or lower spontaneous EEG and behavioral seizure activity and compared to pre-kindling records. We found: (1) before and after kindling, NE and 5-HT but not DA concentrations were significantly lower in sleep than waking at both sites; (2) after kindling, each cat showed cyclic patterns, as follows: (a) higher NE, 5-HT and DA concentrations accompanied increased seizure activity with delayed sleep onset latency and increased sleep fragmentation (reduced sleep state percentages, number of epochs and/or epoch duration) in one recording versus (b) lower monoaminergic concentrations accompanied reduced seizure activity, rapid sleep onset and reduced sleep disruption in the other recording. The alternating, post-kindling pattern suggested "rebound" effects which could explain some controversies in the literature about chronic effects of kindling on monoamines and sleep-waking state patterns.
journal_name
Brain Resjournal_title
Brain researchauthors
Shouse MN,Staba RJ,Saquib SF,Farber PRdoi
10.1016/s0006-8993(00)03265-0subject
Has Abstractpub_date
2001-02-16 00:00:00pages
147-65issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03265-0journal_volume
892pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:(1) After inoculation of the pseudorabies virus in the anterior chamber of the eye of the rat, virions can be found only in the neurons of the superior cervical sympathetic ganglion and in the sensory ganglion of the fifth nerve on the inoculated side. Other nervous structures--central or peripheral--are not infected....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90241-x
更新日期：1978-01-20 00:00:00
abstract：:Intracellular free calcium concentration ([Ca2+]i) was measured in cultured explants of myenteric plexus neurones by using the fluorescent calcium indicator Indol in combination with patch-clamp techniques. The basal [Ca2+]i was 94 nM and spontaneous oscillations in the internal free calcium concentration were recorde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90065-u
更新日期：1993-10-08 00:00:00
abstract：:It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.032
更新日期：2013-02-01 00:00:00
abstract：:The objective was to obtain detailed topographic determinations of cytochrome oxidase activity in the gerbil central auditory system at the light microscopic level. Quantitative techniques were developed using (1) tissue standards calibrated to express histochemical measures as actual enzyme activity units, (2) densit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90836-2
更新日期：1994-10-10 00:00:00
abstract：:An in vitro autoradiographic technique has been used to localize [125I]omega-conotoxin GVIA binding sites in the brains of normal and cerebellar mutant mice. In the brains of normal mice, the highest densities of binding sites were observed at glomeruli of the olfactory bulb, cerebral cortex, caudate nucleus-putamen, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90004-8
更新日期：1989-06-05 00:00:00
abstract：:Electrophysiological characteristics were described for neurons of the parabrachial nucleus (PBN) which receive baroreceptive and somatosensory inputs in the rat. Following focal electrical stimulation in the ipsilateral caudal nucleus of the tractus solitarii (NTS), the firing rates of these neurons were increased in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91704-5
更新日期：1991-12-06 00:00:00
abstract：:While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00726-7
更新日期：1995-09-18 00:00:00
abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90589-5
更新日期：1986-03-19 00:00:00
abstract：:Gamma-hydroxybutyrate (GHB) has been shown to have therapeutical properties in various psychiatric disorders, especially in alcohol abuse, and to mimic different actions of ethanol at the cellular and system level. Using whole-cell patch-clamp recordings on brain slices of 21- to 25-day-old rats, the present study inv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.046
更新日期：2004-01-30 00:00:00
abstract：:We studied the propagation of spike discharges and the changes in local cerebral blood flow (LCBF) by means of the electroencephalogram (EEG) and autoradiographs to elucidate the underlying mechanism and the propagation pathway in rats with limbic seizures. Seizures were induced by the unilateral microinjection of kai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91923-2
更新日期：1994-01-21 00:00:00
abstract：:To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03285-6
更新日期：2001-03-02 00:00:00
abstract：:Adequate grip force modulation is critical to manual dexterity and often impaired in hemiparetic stroke patients. Previous studies in hemiparetic patients suggest that aspects of grip force control may be differently affected by the lesion. We developed a visuomotor power grip force-tracking task allowing quantificati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.007
更新日期：2012-05-03 00:00:00
abstract：:The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.023
更新日期：2012-04-27 00:00:00
abstract：:Pain resulting from peripheral nerve injury, characterised by ongoing pain, hyperalgesia and allodynia arises from peripheral and central processes. Here, we studied the potential role of central facilitations in nerve injury by investigating the effect of blocking the excitatory 5HT3 receptor with ondansetron. 5HT3 r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.108
更新日期：2004-09-03 00:00:00
abstract：:The effects of sodium valproate on extracellularly recorded spontaneous neuronal activity and its interaction with GABA-induced inhibition were assessed in the rat medial basal hypothalamus both in situ and in explant culture. In situ, valproate enhanced the spontaneous rate in 14 of 20 neurons sampled, 6 neurons were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90288-2
更新日期：1981-08-24 00:00:00
abstract：INTRODUCTION:Ischemic postconditioning (IpostC) has been described in both heart and brain. The first aim of this study was to evaluate the effects of IpostC on brain infarct size and neurological function in the middle cerebral artery occlusion (MCAO) model. The second aim was to determine the involvement of the mitoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.054
更新日期：2011-02-23 00:00:00
abstract：:The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91318-1
更新日期：1986-02-26 00:00:00
abstract：:Locomotor stepping elicited by lateral hypothalamic stimulation in the anesthetized rat is blocked by lesions in the anterior ventromedial midbrain. This study determined in acute experiments whether the dorsal midbrain regions implicated in locomotion were also part of the necessary pathway. Rats were anesthetized wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91049-3
更新日期：1987-01-27 00:00:00
abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.009
更新日期：2005-05-31 00:00:00
abstract：:Oxytocin properties have been studied in different experimental models in order to obtain evidence for its analgesic properties. The analgesic effect of an oxytocinergic pathway descending from the hypothalamus reaching the dorsal horn of the spinal cord has been studied. In anesthetized rats, we recorded single units...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.050
更新日期：2006-04-07 00:00:00
abstract：:During a recent study of the effects of photoreceptor degeneration on Muller cells, we observed that unlike glia from normal adult retinas, glia from degenerating rat retinas could be cultured and maintained in vitro for several weeks. Using a variety of cell type specific antisera, we show that at least 70% of cells ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91618-x
更新日期：1985-06-24 00:00:00
abstract：:Following extirpation of three quarters of the eye anlage of Xenopus laevis in stage 33/34, the remaining quadrants developed into small eyes of normal shape. Irrespective of the different portions of the eye anlage the quarter eyes originated from, the retinotectal projection was always confined to the rostrolateral ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90089-1
更新日期：1986-09-01 00:00:00
abstract：:The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91058-m
更新日期：1992-11-13 00:00:00
abstract：:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90910-4
更新日期：1990-05-14 00:00:00
abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.028
更新日期：2006-01-05 00:00:00
abstract：:The understanding of sarcasm reflects a complex process, which involves recognizing the beliefs of the speaker. There is a clear association between deficits in mentalizing, which is the ability to understand other people's behavior in terms of their mental state, and the understanding of sarcasm in individuals with a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.088
更新日期：2006-12-08 00:00:00
abstract：:Recently, a novel method for detection of DNA synthesis has been developed based on the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction). In the present stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.092
更新日期：2010-03-10 00:00:00
abstract：:A morphosyntactic agreement violation during reading elicits a well-documented biphasic ERP pattern (LAN+P600). The cognitive variables that affect both the amplitude of the two components and the topography of the anterior negativity are still debated. We studied the ERP correlates of the violation of a specific agre...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2008.06.064
更新日期：2008-09-04 00:00:00
abstract：:The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90395-4
更新日期：1981-12-28 00:00:00
abstract：:Recent researches suggest that autophagic degradation declines with age, and this leads to an accumulation of damage that contributes to age-related cellular dysfunction. Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) shows therapeutic potential for cerebral ischemia in young-adult animals. This study inve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146391
更新日期：2019-11-15 00:00:00
