Abstract：
:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redundant patterns. In the present work, we compared the brain expression patterns of the class III semaphorins 3A, 3C, and 3F and neuropilins 1 and 2 between mouse and chick embryos at early developmental stages. Our studies revealed that expression of semaphorins is restricted in some cases to neuromeric transverse domains, to specific neuromeric boundaries, and to specific neuronal populations. Moreover, our studies also revealed coexpression of neuropilins and one or more semaphorins in some of the different expression sites. Comparison of the expression patterns between mouse and chick embryos showed large similarities, but important differences were also detected.
journal_name
Brain Resjournal_title
Brain researchauthors
Meléndez-Herrera E,Varela-Echavarría Adoi
10.1016/j.brainres.2005.10.028subject
Has Abstractpub_date
2006-01-05 00:00:00pages
126-37issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(05)01434-4journal_volume
1067pub_type
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