Neurophysiological abnormalities in cultured dorsal root ganglion neurons from the trisomy-16 mouse fetus, a model for Down syndrome.

Abstract:

:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repolarization compared to diploid neurons, resulting in decreased spike duration. These changes match those reported in human trisomy-21 DRG neurons. Such abnormalities may contribute to the mental retardation characteristic of Down syndrome.

journal_name

Brain Res

journal_title

Brain research

authors

Ault B,Caviedes P,Rapoport SI

doi

10.1016/0006-8993(89)90678-1

subject

Has Abstract

pub_date

1989-04-17 00:00:00

pages

165-70

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)90678-1

journal_volume

485

pub_type

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