Abstract:
:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repolarization compared to diploid neurons, resulting in decreased spike duration. These changes match those reported in human trisomy-21 DRG neurons. Such abnormalities may contribute to the mental retardation characteristic of Down syndrome.
journal_name
Brain Resjournal_title
Brain researchauthors
Ault B,Caviedes P,Rapoport SIdoi
10.1016/0006-8993(89)90678-1subject
Has Abstractpub_date
1989-04-17 00:00:00pages
165-70issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90678-1journal_volume
485pub_type
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