当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats.

Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats.

Abstract：

:The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotensin (ANG) II-induced hypertensive rats. Three minutes after MβCD administration (5 mg/kg), acute hypertension was induced by ANG II (60 µg/kg). Evans blue (EB) and horseradish peroxidase (HRP) tracers were used to assess BBB permeability. Immunohistochemistry for caveolin (Cav)-1 and tight junction protein claudin-5 was performed. EB dye content significantly increased in both cerebral cortices and left hippocampus in MβCD (P < 0.05), right cerebral cortex and both hippocampi in ANG II (P < 0.05; P < 0.01), and both cerebral cortices and hippocampi in MβCD plus ANG II groups compared with controls (P < 0.05; P < 0.01). A significant decrease in claudin-5 immunostaining intensity was observed in animals treated with MβCD compared with controls (P < 0.05). Cav-1 immunostaining intensity increased in ANG II group (P < 0.05). Ultrastructurally, HRP reaction products were observed in endothelial cells of the microvessels in the hippocampus region in MβCD group while the tracer was mainly localized in astrocytes and neurons in ANG II, and MβCD plus ANG II groups. The endothelial cells of the venules in the cerebral cortex of the animals in the latter experimental groups also showed an abundance of caveolar vesicles devoid of HRP reaction products. Our results revealed that MβCD did not provide overall protective effects on BBB integrity in acute hypertension and even led to BBB disruption in normotensive animals.

journal_name

Brain Res

journal_title

Brain research

authors

Atış M,Akcan U,Uğur Yılmaz C,Orhan N,Düzgün P,Deniz Ceylan U,Arıcan N,Karahüseyinoğlu S,Nur Şahin G,Ahıshalı B,Kaya M

doi

10.1016/j.brainres.2019.03.024

subject

Has Abstract

pub_date

2019-07-15 00:00:00

pages

148-155

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(19)30163-5

journal_volume

1715

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats.

    abstract：:Recent research suggests that in addition to its prominent role in appetitive learning, the nucleus accumbens (NAC) may also be involved in fear conditioning. In the present study, we investigated whether temporary inactivation of the NAC, by injection of tetrodotoxin (TTX), affects acquisition and expression of condi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.08.037

    authors： Schwienbacher I,Fendt M,Richardson R,Schnitzler HU

    更新日期：2004-11-19 00:00:00

  • Output organization of the feline entopeduncular and subthalamic nuclei.

    abstract：:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(78)90993-9

    authors： Larsen KD,Sutin J

    更新日期：1978-11-17 00:00:00

  • Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brain.

    abstract：:Reactive oxygen species (ROS) and intrinsic antioxidant defense systems play an important role in both physiological cell signaling processes and many pathological states, including neurodegenerative disorders and oxygen-toxicity. Here we report that short exposures to non-physiologic oxygen levels change the balance ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2012.09.024

    authors： Bendix I,Weichelt U,Strasser K,Serdar M,Endesfelder S,von Haefen C,Heumann R,Ehrkamp A,Felderhoff-Mueser U,Sifringer M

    更新日期：2012-11-12 00:00:00

  • Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine.

    abstract：:We have successfully constructed a mouse neuronal N1E-115 cell line stably expressing a fully functional human dopamine transporter (hDAT). Previous studies in our laboratory have produced several anti-idiotypic Ab2beta antibodies that mimic the configuration of the cocaine molecule at their antigen-combining site. In...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02491-4

    authors： Ho M,Segre M

    更新日期：2000-07-28 00:00:00

  • Immunocytochemical and biochemical studies with the monoclonal antibody 69A1: similarities of the antigen with cell adhesion molecules L1, NILE and Ng-CAM.

    abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(86)90087-8

    authors： Pigott R,Kelly JS

    更新日期：1986-09-01 00:00:00

  • Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus.

    abstract：:To gain insight into ATP-binding cassette transporter A1 (ABCA1) function and its potential role in AD pathology, we analyzed the expression of the cholesterol transporter ABCA1 in postmortem hippocampus from persons at different stages of dementia and AD associated neuropathology relative to cognitively intact normal...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.01.006

    authors： Akram A,Schmeidler J,Katsel P,Hof PR,Haroutunian V

    更新日期：2010-03-08 00:00:00

  • Enteric origin of bombesin immunoreactive fibres in the rat coeliac-superior mesenteric ganglion.

    abstract：:Bombesin-like immunoreactivity occurs in a dense network of nerve fibres in the rat coeliac-superior mesenteric ganglion. No bombesin immunoreactive cell bodies have been observed in this ganglion. An origin outside the ganglion was therefore assumed for the bombesin immunoreactive fibres. Ligation of the mesenteric n...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)90981-2

    authors： Schultzberg M,Dalsgaard CJ

    更新日期：1983-06-13 00:00:00

  • Dorsomedial hindbrain participation in glucoprivic feeding response to 2DG but not 2DG-induced hyperglycemia or activation of the HPA axis.

    abstract：:2-Deoxy-d-glucose (2DG) is a glucose analogue that inhibits intracellular utilization of glucose and produces a characteristic behavioral response known as glucoprivic feeding. The area postrema (AP) is a caudal hindbrain structure shown previously to be involved in 2DG-induced glucoprivic feeding. In addition, periph...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00528-9

    authors： Edmonds BK,Edwards GL

    更新日期：1998-08-10 00:00:00

  • Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine.

    abstract：:Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-D-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesti...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)91202-c

    authors： Wolf ME,Khansa MR

    更新日期：1991-10-18 00:00:00

  • Intracellular distribution of monoamine oxidase A in selected regions of rat and monkey brain and spinal cord.

    abstract：:Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. In this study, monoclonal antibodies that recognize rat or monkey MAO A were used in immunocytochemical studies ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91664-e

    authors： Westlund KN,Krakower TJ,Kwan SW,Abell CW

    更新日期：1993-05-28 00:00:00

  • A1 neurons and excitatory amino acid receptors in rat caudal medulla mediate vagal excitation of supraoptic vasopressin cells.

    abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91131-w

    authors： Day TA,Sibbald JR,Smith DW

    更新日期：1992-10-30 00:00:00

  • Quantification of extracellular levels of corticosterone in the basolateral amygdaloid complex of freely-moving rats: a dialysis study of circadian variation and stress-induced modulation.

    abstract：:Corticosterone influences emotion and cognition via actions in a diversity of corticolimbic structures, including the amygdala. Since extracellular levels of corticosterone in brain have rarely been studied, we characterized a specific and sensitive enzymatic immunoassay for microdialysis quantification of corticoster...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2012.01.010

    authors： Bouchez G,Millan MJ,Rivet JM,Billiras R,Boulanger R,Gobert A

    更新日期：2012-05-03 00:00:00

  • Ipsiversive turning behaviour after discrete unilateral lesions of the dorsal mesencephalic reticular formation by kainic acid.

    abstract：:Discrete axon-sparing lesions were placed unilaterally in the mesencephalon by the local injection of kainic acid. Unilateral lesions of the dorsal reticular formation just beneath the superior colliculus and lateral to the periacqueductal grey resulted in consistent ipsiversive apomorphine-induced circling. Only weak...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(81)90579-5

    authors： Mulas A,Longoni R,Spina L,Del Fiacco M,Di Chiara G

    更新日期：1981-03-16 00:00:00

  • Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine.

    abstract：:Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)91124-7

    authors： Gold PE,Delanoy RL,Merrin J

    更新日期：1984-07-02 00:00:00

  • Reduced spontaneous neuronal activity in the insular cortex and thalamus in healthy adults with insomnia symptoms.

    abstract：:Poor sleep and insomnia have been recognized to be strongly correlated with the development of depression. The exploration of the basic mechanism of sleep disturbance could provide the basis for improved understanding and treatment of insomnia and prevention of depression. In this study, 31 subjects with insomnia symp...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2016.07.024

    authors： Liu CH,Liu CZ,Zhang J,Yuan Z,Tang LR,Tie CL,Fan J,Liu QQ

    更新日期：2016-10-01 00:00:00

  • Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons.

    abstract：:The bag cell neurons of Aplysia are capable of generating an afterdischarge, which, in vivo, triggers egg-laying behavior. Pharmacologic elevation of cyclic AMP levels in isolated bag cell neurons has been shown to initiate repetitive firming similar to that seen during an afterdischarge, and to decrease outward curre...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)91733-w

    authors： Loechner KJ,Kaczmarek LK

    更新日期：1990-11-05 00:00:00

  • Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats.

    abstract：:The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00512-5

    authors： Ino-ue M,Ohgiya N,Yamamoto M

    更新日期：1998-08-03 00:00:00

  • The dendritic trees of Purkinje cells: a computer assisted analysis of HRP labeled neurons in organotypic cultures of kitten cerebellum.

    abstract：:Purkinje cell dendritic arborizations were studied in HRP intracellularly stained mature neurons grown during 30-50 days in organotypic cerebellar cultures from newborn kittens. The effects of afferent fiber depletions on the final dendritic topological parameters were investigated by computer assisted methods. Three ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)90051-3

    authors： Calvet MC,Calvet J,Camacho R,Eude D

    更新日期：1983-12-05 00:00:00

  • Resting hippocampal blood flow, spatial memory and aging.

    abstract：:Aging is accompanied by a general deterioration of fluid cognitive processes and a reduction in resting cerebral blood flow (CBF). While the two phenomena have been observed independently, it is uncertain whether individual differences in cerebral blood flow are reliably associated with cognitive functioning in older ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.12.020

    authors： Heo S,Prakash RS,Voss MW,Erickson KI,Ouyang C,Sutton BP,Kramer AF

    更新日期：2010-02-22 00:00:00

  • Differential labelling of primary olfactory system subcomponents by SBA (lectin) and NADPH-d histochemistry in the frog Pipa.

    abstract：:SBA and NADPH-d histochemistries allow identification of functionally distinct components of the amphibian primary olfactory system. In Pipa, a secondarily aquatic frog, combination of both methodologies, using alternate sets of histological sections, reveals that, apart from Jacobson's organ, this species has a "wate...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(97)00507-6

    authors： Meyer DL,Fackler IR,Jadhao AG,D'Aniello B,Kicliter E

    更新日期：1997-07-11 00:00:00

  • Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: an animal model of resistance to epilepsy.

    abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.03.031

    authors： Araujo BH,Torres LB,Cossa AC,Naffah-Mazzacoratti Mda G,Cavalheiro EA

    更新日期：2010-06-04 00:00:00

  • The tuberal lateral hypothalamus is a major target for GABAA--but not GABAB-mediated control of food intake.

    abstract：:The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.05.064

    authors： Turenius CI,Charles JR,Tsai DH,Ebersole PL,Htut MH,Ngo PT,Lara RN,Stanley BG

    更新日期：2009-08-04 00:00:00

  • The clustered cell system is present before formation of the ACh patches in the intermediate gray layer of the cat superior colliculus.

    abstract：:Projection neurons from the superior colliculus (SC) to the cuneiform region (CFR) of the midbrain form distinct cell clusters in the intermediate gray layer which precisely overlap the cholinergic fiber patches in this region of the cat SC (Jeon and Mize, J. Comp. Neurol., 337 (1993) 127-150). The acetylcholine (ACh)...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(96)00563-x

    authors： Banfro FT,Mize RR

    更新日期：1996-09-16 00:00:00

  • Cardiovascular responses to intravenous injection of a novel isoindolin-1-one derivate in conscious rats.

    abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.08.092

    authors： Shirasaka T,Kunitake T,Tsuneyoshi I

    更新日期：2009-12-01 00:00:00

  • Putative nociceptive modulatory neurons in the dorsolateral pontomesencephalic reticular formation.

    abstract：:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90171-6

    authors： Haws CM,Williamson AM,Fields HL

    更新日期：1989-04-03 00:00:00

  • Interleukin-1 (IL-1) stimulates arginine vasopressin (AVP) release from superfused rat hypothalamo-neurohypophyseal complexes independently of cholinergic mechanism.

    abstract：:We studied whether interleukin-1 (IL-1) affects the release of arginine vasopressin (AVP) from the superfused hypothalamo-neurohypophyseal complex (HNC) of rats. Involvement of the cholinergic system in the mediation of IL-1 on AVP release from HNC was also examined. Both human recombinant IL-1 alpha and -1 beta elici...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)90169-v

    authors： Nakatsuru K,Ohgo S,Oki Y,Matsukura S

    更新日期：1991-07-19 00:00:00

  • Optical responses evoked by white matter stimulation in rat visual cortical slices and their relation to neural activities.

    abstract：:To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time aft...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(96)00767-6

    authors： Tanifuji M,Yamanaka A,Sunaba R,Terakawa S,Toyama K

    更新日期：1996-10-28 00:00:00

  • Increased [3H]glutamate receptor binding in aged rats.

    abstract：:Na-independent [3H]glutamate binding to rat hippocampal membranes increases progressively as a function of age. The increased binding represents an increased number of binding sites without changes in their apparent affinity for glutamate. However, [3H]glutamate binding, measured with a saturating concentration of cal...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(81)90823-4

    authors： Baudry M,Arst DS,Lynch G

    更新日期：1981-10-26 00:00:00

  • Neurotransmitter-related markers in the normal and experimentally lesioned telencephalon of the goldfish.

    abstract：:The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes. Experimental results (resection of the olfactory tracts or unilateral kainic acid administration in the telencephalon) suggest that: the projection from the ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90823-6

    authors： Bissoli R,Contestabile A,Marotta L,Poli A,Migani P

    更新日期：1985-10-07 00:00:00

  • Cardiovascular effects of substance P and capsaicin microinjected into the nucleus tractus solitarii of the rat.

    abstract：:This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90938-3

    authors： Lukovic L,de Jong W,de Wied D

    更新日期：1987-10-06 00:00:00