Abstract：
:To gain insight into ATP-binding cassette transporter A1 (ABCA1) function and its potential role in AD pathology, we analyzed the expression of the cholesterol transporter ABCA1 in postmortem hippocampus from persons at different stages of dementia and AD associated neuropathology relative to cognitively intact normal donors by quantitative polymerase chain reaction (qPCR) and Western blot. In this study clinical dementia rating (CDR) scores were used as a measure of dementia severity, whereas, Braak neuropathological staging and neuritic plaque density were used as an index of the neuropathological progression of AD. Correlation analysis showed that ABCA1 mRNA expression was significantly elevated at the earliest recognizable stage of dementia compared to persons with intact cognition. ABCA1 mRNA was also positively correlated with Braak neuropathological stages and neuritic plaque density counts. Additionally, ABCA1 mRNA levels showed robust correlation with dementia severity even after controlling for the confounding contribution of accompanying neuropathological parameters to ABCA1 mRNA expression. Western blot analyses showed that the differential expression observed at the transcriptional level is also reflected at the protein level. Thus, our study provides transcriptional and translational evidence that the expression of ABCA1, a key modulator of cholesterol transport across the plasma membrane, is dysregulated in the AD brain and that this dysregulation is associated with increasing severity of AD, whether measured functionally as dementia severity or neuropathologically as increased neuritic plaque and neurofibrillary tangle density.
journal_name
Brain Resjournal_title
Brain researchauthors
Akram A,Schmeidler J,Katsel P,Hof PR,Haroutunian Vdoi
10.1016/j.brainres.2010.01.006subject
Has Abstractpub_date
2010-03-08 00:00:00pages
167-77eissn
0006-8993issn
1872-6240pii
S0006-8993(10)00009-0journal_volume
1318pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Prostanoids in the central nervous system define an important linkage between blood pressure and hormonal responses to hypotension/ischemia. Prostaglandin endoperoxide synthase (PGHS)-2, the inducible isoform of this enzyme, is induced by cerebral hypoperfusion/ischemia. To investigate the mechanism of the PGHS-2 gene...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.08.033
更新日期：2005-10-26 00:00:00
abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90016-2
更新日期：1987-09-01 00:00:00
abstract：:Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91127-7
更新日期：1983-03-28 00:00:00
abstract：:Several regulated mRNAs were detected by applying differential display to the mouse cerebellum during postnatal development. One cDNA fragment, referred to as CPD1 (GenBank U89345), was characterized and cloned. Northern blots showed maximum mRNA expression at postnatal day seven (P7). The mRNA encodes a protein of 26...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02351-4
更新日期：2001-07-13 00:00:00
abstract：:We previously described a rat model where the injection of formalin in the tail induced a facilitation of the hindpaw withdrawal reflexes (hyperalgesia). In the present work, after injecting formalin in the tail, we measured the levels of pro-nociceptive mediators tumor necrosis factor-alpha (TNF) and substance P (SP)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.007
更新日期：2004-09-03 00:00:00
abstract：:Influence of dopamine agonists, methamphetamine (MAT, 1 mg/kg, i.p.) and apomorphine (APO, 1 mg/kg, i.p.), on the effects of amygdaloid lesions on thresholds for the defensive attack behavior elicited by electrical stimulation of the ventromedial hypothalamic nucleus was studied in cats. The thresholds were measured i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90665-7
更新日期：1986-01-15 00:00:00
abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 blocks the ability of D-methamphetamine (MA) to deplete striatal dopamine (DA). We now report that MK-801 attenuates decreases in serotonin (5-HT) concentration induced by MA and two other amphetamine analogues, 3,4-methylenedioxymethamphetamin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91460-v
更新日期：1992-11-06 00:00:00
abstract：:Rats trained to walk in a moving belt apparatus were subjected to a partial (fornix-fimbria (FF] or total (fornix-fimbria + cingulum bundles (FF + CB] chemical denervation of the dorsal serotonergic afferent pathways to the hippocampus. After chronic alcohol treatment that resulted in tolerance development to the moto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90037-x
更新日期：1985-02-11 00:00:00
abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91105-8
更新日期：1978-09-08 00:00:00
abstract：:Neural transplantation is a promising approach for treating neurodegenerative disease. Neural stem/progenitor cells (NPCs) are self-renewing and multipotent and thus are good candidates for donor cells when they have been clearly defined to differentiate into neurons. As neuronal differentiation follows cell cycle exi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.046
更新日期：2006-05-30 00:00:00
abstract：:The present study was designed to investigate the role of activation of Kca+2 channels and cAMP in opioid-induced pial artery dilation in newborn pigs equipped with closed cranial windows. Methionine enkephalin, an endogenous mu agonist, elicited dilation that was modestly attenuated by the Kca+2 channel antagonist, i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01284-x
更新日期：1997-02-07 00:00:00
abstract：:We have conducted studies in intact adult male rats, designed to examine the effect of a 3- or 7-day exposure to alcohol (EtOH) on the pituitary's response to corticotropin-releasing hormone (CRF) or stress, and on CRF expression in the hypothalamus. In a first series of experiments, rats exposed to EtOH vapors for 7 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91685-a
更新日期：1990-06-18 00:00:00
abstract：:Brain edema (BE) is an uncommon but life-threatening complication of severe diabetic ketoacidosis (DKA) and its treatment. Despite advances in treatment of DKA, the pathogenesis of both initiation and progression of the associated BE is unclear. In the present study we examined the blood brain barrier (BBB) integrity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.100
更新日期：2009-02-13 00:00:00
abstract：:The cataleptic activity of morphine and methadone was markedly potentiated in frontally decorticated rats with no apparent changes in the onset or duration of action. Enhancement of the opioid cataleptic response was not due to changes in the availability of the drugs in the brain. The potentiation of methadone-induce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91028-1
更新日期：1988-05-24 00:00:00
abstract：:In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90430-7
更新日期：1989-06-19 00:00:00
abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90087-8
更新日期：1986-09-01 00:00:00
abstract：:Human subjects were asked to perform sinusoidal tracking movements (0.5--3.0 Hz) with their forearms while external torque disturbances were applied at the elbow. The changes in angular position, velocity, and acceleration produced by these disturbances were found to be represented in the reflex changes in EMG activit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90946-4
更新日期：1980-07-07 00:00:00
abstract：:The solubilized rat central nervous system (hypothalamic) nicotinic cholinergic receptor and the Torpedo nicotinic cholinergic receptors are immunologically similar and show greater than 60% immunologic cross-reactivity using a double-antibody technique. Antibodies to the Electrophorus and Torpedo receptors also decre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90700-5
更新日期：1979-12-14 00:00:00
abstract：:Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02297-1
更新日期：2001-05-11 00:00:00
abstract：:We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 microM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose-dependent manner (I...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00343-0
更新日期：1997-06-13 00:00:00
abstract：:Synapses from Mauthner to giant fibers in the hatchetfish are chemically transmitting excitatory axo-axonic synapses located in the medulla. The synapses are 4--10 mum in diameter and easily identified for electron microscopy. Presynaptic vesicles are clustered near the contact regions and are round, clear and 40-60 n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90002-5
更新日期：1975-11-14 00:00:00
abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03099-2
更新日期：2001-11-30 00:00:00
abstract：:The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90073-0
更新日期：1981-06-01 00:00:00
abstract：:The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.03.024
更新日期：2019-07-15 00:00:00
abstract：:The normal patterns of the occurrence of tryptophan, 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and monoamine oxidase (MAO) activity in chick brain during development were investigated. Tryptophan level in the brain on the 7th day of embryonic development was rather high and decreased gradually un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90183-3
更新日期：1975-08-15 00:00:00
abstract：:Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV(+) subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. The HIV-derived glyco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01572-3
更新日期：1999-07-31 00:00:00
abstract：:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90352-v
更新日期：1991-08-02 00:00:00
abstract：:Following cholinergic denervation of the hippocampus by medial septal lesions, and unusual neuronal reorganization occurs, in which peripheral sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previously, we have found that both hippocampal sympathetic ingrowth (HSI) and ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00070-7
更新日期：1995-04-10 00:00:00
abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.038
更新日期：2005-09-28 00:00:00
abstract：:The current study was performed to evaluate the mechanisms and therapeutic effects of overexpressing neuroglobin (Ngb) on spinal cord injury (SCI). Adeno-associated virus (AAV) was injected in the T12 section 7 days before SCI. Animals were randomly divided into four groups: a sham group, a vehicle group, an AAV-EGFP ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.03.020
更新日期：2014-05-08 00:00:00
